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Shc3
Gene Detail
Symbol

Name
ID
Shc3
src homology 2 domain-containing transforming protein C3
MGI:106179
Synonyms
N-Shc, Rai, ShcC
Feature Type
protein coding gene
Genetic Map
Chromosome 13
26.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:51431041-51567084 bp, - strand
From NCBI annotation of GRCm38

  136044 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:7536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: SHC-transforming protein
Gene Tree: Shc3

Human
homologs
Human Homolog SHC3, SHC (Src homology 2 domain containing) transforming protein 3
NCBI Gene ID 53358
neXtProt AC  NX_Q92529
Human Synonyms  N-Shc, NSHC, RAI, SHCC
Human Chr (Location)  9q22.1; chr9:89005771-89178767 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display a normal phenotype.
 
Interactions
Shc3 interacts with 15 markers (Mir192, Mir221, Mir224, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process central nervous system development, epidermal growth factor receptor signaling pathway, ...
Component plasma membrane
Function protein binding, protein kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (181)    Tissues (76)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 90
In situ reporter (knock in) 7
Western blot 14
RT-PCR 56
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021448 (Evidence)
Entrez Gene20418 (Evidence)
UniGene131870
DFCITC1591371
DoTSDT.91332858, DT.110958830
NIA Mouse Gene IndexU034776
Consensus CDS ProjectCCDS49265.1
International Mouse Knockout Project StatusShc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20418 NCBI Gene Model | MGI Sequence Detail 136044 C57BL/6J ±  kb
transcript NM_009167 RefSeq | MGI Sequence Detail 1540 Not Specified 
polypeptide Q61120 UniProt | EBI | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(490 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR006019 Phosphotyrosine interaction (PID/PI)
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000980 SH2 domain
Protein Ontology PR:000003181 SHC-transforming protein 3
Graphical View of Protein Domain Structure
References
(Earliest) J:32205 O'Bryan JP, et al., A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2729-34
(Latest) J:206879 Huang T, et al., BDNF and NT4 play interchangeable roles in gustatory development. Dev Biol. 2014 Feb 15;386(2):308-20
All references(41)
Other
accession IDs
MGD-MRK-33869

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory