About   Help   FAQ
Shc3 Gene Detail
Summary
  • Symbol
    Shc3
  • Name
    src homology 2 domain-containing transforming protein C3
  • Synonyms
    N-Shc, Rai, ShcC
  • Feature Type
    protein coding gene
  • IDs
    MGI:106179
    NCBI Gene: 20418
  • Gene Overview
    MyGene.info: SHC3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:51431041-51567084 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      136044 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 26.12 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SHC3, SHC adaptor protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SHC3, SHC adaptor protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    N-Shc, NSHC, RAI, SHCC
  • Links
    NCBI Gene ID: 53358
    neXtProt AC: NX_Q92529
    UniProt: Q92529

  • Chr Location
    9q22.1; chr9:89005771-89182308 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    14 phenotype references
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20418 NCBI Gene Model | MGI Sequence Detail 136044 C57BL/6J ±  kb
transcript NM_009167 RefSeq | MGI Sequence Detail 2248 C57BL/6  
polypeptide Q61120 UniProt | EBI | MGI Sequence Detail 474 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    489 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 13
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33869
References
more
  • Summaries
    All 46
    Developmental Gene Expression 11
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:259186 Heng X, et al., Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. Elife. 2017 May 10;6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/09/2018
MGI 6.12
The Jackson Laboratory