Shc3
Gene Detail

Symbol Name ID

Shc3 src homology 2 domain-containing transforming protein C3 MGI:106179

Synonyms

N-Shc, Rai, ShcC

Feature Type

protein coding gene

Genetic Map

Chromosome 13

26.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:51431041-51567084 bp, - strand From NCBI annotation of GRCm38   136044 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 zebrafish

Protein SuperFamily: SHC-transforming protein
Gene Tree: Shc3

Human homologs

Human Homolog		SHC3, SHC (Src homology 2 domain containing) transforming protein 3
NCBI Gene ID		53358
neXtProt AC		NX_Q92529
Human Synonyms		N-Shc, NSHC, RAI, SHCC
Human Chr (Location)		9q22.1; chr9:91620686-91793682 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Mice homozygous for disruptions in this gene display a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	intracellular signal transduction, learning or memory, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (181)    Tissues (75)    Images (30)
Theiler Stages: 17, 20, 22, 23, 24, 28

Assay Type	Results
Immunohistochemistry	14
RNA in situ	90
In situ reporter (knock in)	7
Western blot	14
RT-PCR	56

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(14) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000021448 (Evidence)
Entrez Gene	20418 (Evidence)
UniGene	131870
DFCI	TC1591371
DoTS	DT.110958830, DT.91332858
NIA Mouse Gene Index	U034776
Consensus CDS Project	CCDS49265.1
International Mouse Knockout Project Status	Shc3

Sequences

Length	Strain/Species
genomic	20418	NCBI Gene Model | MGI Sequence Detail	136044	C57BL/6J
transcript	NM_009167	RefSeq | MGI Sequence Detail	1540	Not Specified
polypeptide	Q61120	UniProt | EBI | MGI Sequence Detail	474	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(480 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006020	Phosphotyrosine interaction domain
InterPro	IPR006019	Phosphotyrosine interaction (PID/PI)
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR000980	SH2 domain
Protein Ontology	PR:000003181	shc-transforming protein 3

Graphical View of Protein Domain Structure

References

(Earliest) J:32205 O'Bryan JP, et al., A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2729-34
(Latest) J:190181 Ortensi B, et al., Rai is a new regulator of neural progenitor migration and glioblastoma invasion. Stem Cells. 2012 May;30(5):817-32
All references(38)

Other accession IDs

MGD-MRK-33869