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Shc3
Gene Detail
 Symbol
Name
ID
Shc3
src homology 2 domain-containing transforming protein C3
MGI:106179
Synonyms N-Shc, Rai, ShcC
Feature Type protein coding gene
Genetic Map
Chromosome 13
26.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:51431041-51567084 bp, - strand
From NCBI annotation of GRCm38

  136044 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 zebrafish

Protein SuperFamily: SHC-transforming protein
Gene Tree: Shc3

Human
homologs
Human Homolog SHC3, SHC (Src homology 2 domain containing) transforming protein 3
NCBI Gene ID 53358
neXtProt AC  NX_Q92529
Human Synonyms  N-Shc, NSHC, RAI, SHCC
Human Chr (Location)  9q22.1; chr9:89005771-89178767 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(3) Gene trapped(2)
 
Mice homozygous for disruptions in this gene display a normal phenotype.
 
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process intracellular signal transduction, learning or memory, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (181)    Tissues (75)    Images (30)
Theiler Stages: 17, 20, 22, 23, 24, 28
Assay TypeResults
Immunohistochemistry 14
RNA in situ 90
In situ reporter (knock in) 7
Western blot 14
RT-PCR 56
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021448 (Evidence)
Entrez Gene20418 (Evidence)
UniGene131870
DFCITC1591371
DoTSDT.110958830, DT.91332858
NIA Mouse Gene IndexU034776
Consensus CDS ProjectCCDS49265.1
International Mouse Knockout Project StatusShc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20418 NCBI Gene Model | MGI Sequence Detail 136044 C57BL/6J ±  kb
transcript NM_009167 RefSeq | MGI Sequence Detail 1540 Not Specified 
polypeptide Q61120 UniProt | EBI | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(490 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR006019 Phosphotyrosine interaction (PID/PI)
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000980 SH2 domain
Protein Ontology PR:000003181 shc-transforming protein 3
Graphical View of Protein Domain Structure
References (Earliest) J:32205 O'Bryan JP, et al., A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2729-34
(Latest) J:198061 Savino MT, et al., The Shc family protein adaptor, Rai, acts as a negative regulator of Th17 and Th1 cell development. J Leukoc Biol. 2013 Apr;93(4):549-59
All references(39)
Other
accession IDs
MGD-MRK-33869

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory