About   Help   FAQ
Loxl1
Gene Detail
Symbol

Name
ID
Loxl1
lysyl oxidase-like 1
MGI:106096
Synonyms
LOXL
Feature Type
protein coding gene
Genetic Map
Chromosome 9
31.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr9:58287723-58313212 bp, - strand
From NCBI annotation of GRCm38

  25490 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4074  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LOXL1
Protein SuperFamily: protein-lysine 6-oxidase
Gene Tree: Loxl1

Human
homologs
LOXL1, lysyl oxidase-like 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4016
neXtProt AC: NX_Q08397

Human Synonyms: LOL, LOXL

Human Chr (Location): 15q22; chr15:73926448-73952137 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LOXL1

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(20) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Elastic fiber homeostasis is disrupted in homozygous mutant mice, resulting in loose skin, abnormal lung morphology, intestinal defects, and post partum uterine prolapse.
 
Interactions
Loxl1 interacts with 154 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process oxidation-reduction process
Component acrosomal vesicle, basement membrane, ...
Function aspartate oxidase activity, copper ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (39)    Tissues (30)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 38
Northern blot 1
cDNA source data(74)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase loxl1 ; ZFIN loxl1    NEW 
Molecular
reagents
All nucleic(77) Genomic(1) cDNA(75) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000032334 (Evidence)
Entrez Gene 16949 (Evidence)
UniGene 250492
DFCI TC1577642, TC1586027, TC1595779
DoTS DT.523420, DT.55123080
NIA Mouse Gene Index U030937
EC 1.4.3.-
Consensus CDS Project CCDS52813.1
International Mouse Phenotyping Consortium Status Loxl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16949 NCBI Gene Model | MGI Sequence Detail 25490 C57BL/6J ±  kb
transcript NM_010729 RefSeq | MGI Sequence Detail 3338 C57BL/6 
polypeptide P97873 UniProt | EBI | MGI Sequence Detail 607 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001695 Lysyl oxidase
InterPro IPR019828 Lysyl oxidase, conserved site
Protein Ontology PR:000009884 lysyl oxidase homolog 1
Graphical View of Protein Domain Structure
References
(Earliest) J:32426 Zuberi AR, et al., A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex. Genomics. 1996 Apr 1;33(1):75-84
(Latest) J:185764 Consonni SR, et al., Elastic fiber assembly in the adult mouse pubic symphysis during pregnancy and postpartum. Biol Reprod. 2012;86(5):151, 1-10
All references(53)
Other
accession IDs
MGD-MRK-33782

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory