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Loxl1 Gene Detail
Summary
  • Symbol
    Loxl1
  • Name
    lysyl oxidase-like 1
  • Synonyms
    LOXL
  • Feature Type
    protein coding gene
  • IDs
    MGI:106096
    NCBI Gene: 16949
  • Gene Overview
    MyGene.info: LOXL1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:58287738-58313186 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25449 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 31.65 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    LOXL1, lysyl oxidase like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LOXL1, lysyl oxidase like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LOL, LOXL
  • Links
    NCBI Gene ID: 4016
    neXtProt AC: NX_Q08397
    UniProt: Q08397

  • Chr Location
    15q24.1; chr15:73926451-73952141 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human LOXL1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Elastic fiber homeostasis is disrupted in homozygous mutant mice, resulting in loose skin, abnormal lung morphology, intestinal defects, and post partum uterine prolapse.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032334 Ensembl Gene Model | MGI Sequence Detail 25449 C57BL/6J ±  kb
    transcript ENSMUST00000061799 Ensembl | MGI Sequence Detail 3297 Not Applicable  
    polypeptide ENSMUSP00000057406 Ensembl | MGI Sequence Detail 607 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      108 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      Genomic 1
      cDNA 75
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33782
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:32426 Zuberi AR, et al., A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex. Genomics. 1996 Apr 1;33(1):75-84
    • Latest
      J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory