Loxl1
Gene Detail

Symbol Name ID

Loxl1 lysyl oxidase-like 1 MGI:106096

Synonyms

LOXL

Feature Type

protein coding gene

Genetic Map

Chromosome 9

31.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr9:58287723-58313212 bp, - strand From NCBI annotation of GRCm38   25490 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4074  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: protein-lysine 6-oxidase
Gene Tree: Loxl1

Human homologs

Human Homolog		LOXL1, lysyl oxidase-like 1
NCBI Gene ID		4016
neXtProt AC		NX_Q08397
Human Synonyms		LOL, LOXL
Human Chr (Location)		15q22; chr15:74218789-74244478 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LOXL1

Alleles and phenotypes

All alleles(23) : Targeted(3) Gene trapped(20)
 

Elastic fiber homeostasis is disrupted in homozygous mutant mice, resulting in loose skin, abnormal lung morphology, intestinal defects, and post partum uterine prolapse.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	oxidation-reduction process
Component	extracellular matrix, extracellular region, ...
Function	copper ion binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (39)    Tissues (30)    Images (6)
Theiler Stages: 17, 20, 28

Assay Type	Results
RNA in situ	38
Northern blot	1

cDNA source data(72)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(75) Genomic(1) cDNA(73) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032334 (Evidence)
Entrez Gene	16949 (Evidence)
UniGene	250492
DFCI	TC1577642, TC1586027, TC1595779
DoTS	DT.523420, DT.55123080
NIA Mouse Gene Index	U030937
EC	1.4.3.-
Consensus CDS Project	CCDS52813.1
International Mouse Knockout Project Status	Loxl1

Sequences

Length	Strain/Species
genomic	16949	NCBI Gene Model | MGI Sequence Detail	25490	C57BL/6J
transcript	NM_010729	RefSeq | MGI Sequence Detail	3338	C57BL/6
polypeptide	P97873	UniProt | EBI | MGI Sequence Detail	607	Not Applicable

All sequences(23) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(97 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001695	Lysyl oxidase
InterPro	IPR019828	Lysyl oxidase, conserved site
Protein Ontology	PR:000009884	lysyl oxidase 1

Graphical View of Protein Domain Structure

References

(Earliest) J:32426 Zuberi AR, et al., A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex. Genomics. 1996 Apr 1;33(1):75-84
(Latest) J:185764 Consonni SR, et al., Elastic fiber assembly in the adult mouse pubic symphysis during pregnancy and postpartum. Biol Reprod. 2012;86(5):151, 1-10
All references(49)

Other accession IDs

MGD-MRK-33782