About   Help   FAQ
Naca Gene Detail
Summary
  • Symbol
    Naca
  • Name
    nascent polypeptide-associated complex alpha polypeptide
  • Synonyms
    LOC380777, mKIAA0363, skNAC
  • Feature Type
    protein coding gene
  • IDs
    MGI:106095
    NCBI Gene: 17938
  • Gene Overview
    MyGene.info: NACA
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:128035575-128048637 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13063 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 76.39 cM, cytoband D2-D3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NACA, nascent polypeptide associated complex subunit alpha
  • Vertebrate Orthologs
    3
  • Human Ortholog
    NACA, nascent polypeptide associated complex subunit alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSD48, NACA1, NAC-alpha, skNAC
  • Links
    NCBI Gene ID: 4666
    neXtProt AC: NX_E9PAV3, NX_Q13765
    UniProt: E9PAV3, Q13765

  • Chr Location
    12q13.3; chr12:56712427-56726275 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a point mutation exhibit decreased bone volume and bone formation associated with accelerated mineralization and immature woven-bone formation. Mice null for the muscle specific isoform die during organogenesis with cardiac abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061315 Ensembl Gene Model | MGI Sequence Detail 13063 C57BL/6J ±  kb
    transcript ENSMUST00000092048 Ensembl | MGI Sequence Detail 6745 Not Applicable  
    polypeptide ENSMUSP00000089680 Ensembl | MGI Sequence Detail 2187 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      89 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000010950 nascent polypeptide-associated complex subunit alpha
    • InterPro Domains
      IPR038187 NAC A/B domain superfamily
      IPR002715 Nascent polypeptide-associated complex NAC domain
      IPR016641 Nascent polypeptide-associated complex subunit alpha
    Molecular
    Reagents
    less
    • All nucleic 282
      Genomic 2
      cDNA 279
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33781, MGI:2144923, MGI:3037736
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:32006 Yotov WV, et al., Fine mapping of the alpha-NAC gene (Naca) to the distal end (D2-D3) of mouse chromosome 10. Mamm Genome. 1996 Mar;7(3):240
    • Latest
      J:257534 Pellicelli M, et al., Lrp6 is a target of the PTH-activated alphaNAC transcriptional coregulator. Biochim Biophys Acta. 2018 Feb;1861(2):61-71

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory