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Naca Gene Detail
Summary
  • Symbol
    Naca
  • Name
    nascent polypeptide-associated complex alpha polypeptide
  • Synonyms
    LOC380777, mKIAA0363, skNAC
  • Feature Type
    protein coding gene
  • IDs
    MGI:106095
    NCBI Gene: 17938
  • Gene Overview
    MyGene.info: NACA
Location & Maps
more
  • Sequence Map
    Chr10:128035346-128048637 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13292 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 76.39 cM, cytoband D2-D3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NACA, nascent polypeptide-associated complex alpha subunit
  • Vertebrate Orthologs
    3
  • Human Ortholog
    NACA, nascent polypeptide-associated complex alpha subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSD48, NACA1, NAC-alpha, skNAC
  • Links
    NCBI Gene ID: 4666
    neXtProt AC: NX_E9PAV3, NX_Q13765

  • Chr Location
    12q23-q24.1; chr12:56712427-56726275 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a point mutation exhibit decreased bone volume and bone formation associated with accelerated mineralization and immature woven-bone formation. Mice null for the muscle specific isoform die during organogenesis with cardiac abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17938 NCBI Gene Model | MGI Sequence Detail 13292 C57BL/6J ±  kb
transcript NM_001113199 RefSeq | MGI Sequence Detail 7034 Not Specified  
polypeptide P70670 UniProt | EBI | MGI Sequence Detail 2187 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    89 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR002715 Nascent polypeptide-associated complex NAC domain
    IPR016641 Nascent polypeptide-associated complex subunit alpha
Molecular
Reagents
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  • All nucleic 282
    Genomic 2
    cDNA 279
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-33781, MGI:2144923, MGI:3037736
References
more
  • Summaries
    All 43
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:32006 Yotov WV, et al., Fine mapping of the alpha-NAC gene (Naca) to the distal end (D2-D3) of mouse chromosome 10. Mamm Genome. 1996 Mar;7(3):240
  • Latest
    J:225499 Berkholz J, et al., skNAC and Smyd1 in transcriptional control. Exp Cell Res. 2015 Aug 15;336(2):182-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory