Smc2
Gene Detail

Symbol Name ID

Smc2 structural maintenance of chromosomes 2 MGI:106067

Synonyms

5730502P04Rik, CAP-E, Fin16, Smc2l1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

28.31 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr4:52439243-52488260 bp, + strand From VEGA annotation of GRCm38   49018 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4705  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: SMC
Gene Tree: Smc2

Human homologs

Human Homolog		SMC2, structural maintenance of chromosomes 2
NCBI Gene ID		10592
neXtProt AC		NX_O95347
Human Synonyms		CAPE, CAP-E, SMC-2, SMC2L1
Human Chr (Location)		9q31.1; chr9:106856541-106903700 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(17) : Targeted(1) Gene trapped(16)

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	cell cycle, cell division, ...
Component	chromosome, condensed chromosome, ...
Function	ATP binding, nucleotide binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (341)    Tissues (167)    Images (38)
Theiler Stages: 17, 19, 21, 22, 23, 28

Assay Type	Results
RNA in situ	278
Northern blot	17
RT-PCR	46

cDNA source data(161)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(162) cDNA(161) Primer pair(1)
Microarray probesets(10)

Other database links

VEGA Gene Model	OTTMUSG00000007033 (Evidence)
Ensembl Gene Model	ENSMUSG00000028312 (Evidence)
Entrez Gene	14211 (Evidence)
UniGene	2999
DFCI	TC1573075
DoTS	DT.101390533, DT.40147098, DT.55162583, DT.97381182
NIA Mouse Gene Index	U004323
PDB	3L51
Consensus CDS Project	CCDS18180.1
International Mouse Knockout Project Status	Smc2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007033	VEGA Gene Model | MGI Sequence Detail	49018	C57BL/6J
transcript	OTTMUST00000016280	VEGA | MGI Sequence Detail	5404	Not Applicable
polypeptide	OTTMUSP00000007454	VEGA | MGI Sequence Detail	1191	Not Applicable

All sequences(57) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(296 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003395	RecF/RecN/SMC
InterPro	IPR010935	SMCs flexible hinge
InterPro	IPR024704	Structural maintenance of chromosomes protein
Protein Ontology	PR:000015271	structural maintenance of chromosomes protein 2

References

(Earliest) J:32076 Guthridge MA, et al., Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts. Oncogene. 1996 Mar 21;12(6):1267-78
(Latest) J:183026 Lee J, et al., Condensins I and II are essential for construction of bivalent chromosomes in mouse oocytes. Mol Biol Cell. 2011 Sep;22(18):3465-77
All references(45)

Other accession IDs

MGD-MRK-33751, MGI:1915197, MGI:2140211, MGI:2140588