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Smc2
Gene Detail
 Symbol
Name
ID
Smc2
structural maintenance of chromosomes 2
MGI:106067
Synonyms 5730502P04Rik, CAP-E, Fin16, Smc2l1
Feature Type protein coding gene
Genetic Map
Chromosome 4
28.31 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:52439243-52488260 bp, + strand
From VEGA annotation of GRCm38

  49018 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4705  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: SMC
Gene Tree: Smc2

Human
homologs
Human Homolog SMC2, structural maintenance of chromosomes 2
NCBI Gene ID 10592
neXtProt AC  NX_O95347
Human Synonyms  CAPE, CAP-E, SMC-2, SMC2L1
Human Chr (Location)  9q31.1; chr9:104094260-104141419 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(16) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Smc2 interacts with 292 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell cycle, cell division, ...
Component chromosome, condensed chromosome, ...
Function ATP binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (341)    Tissues (167)    Images (38)
Theiler Stages: 17, 19, 21, 22, 23, 28
Assay TypeResults
RNA in situ 278
Northern blot 17
RT-PCR 46
cDNA source data(158)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(159) cDNA(158) Primer pair(1)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000007033 (Evidence)
Ensembl Gene ModelENSMUSG00000028312 (Evidence)
Entrez Gene14211 (Evidence)
UniGene2999
DFCITC1573075
DoTSDT.101390533, DT.40147098, DT.55162583, DT.97381182
NIA Mouse Gene IndexU004323
PDB3L51
Consensus CDS ProjectCCDS18180.1
International Mouse Knockout Project StatusSmc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007033 VEGA Gene Model | MGI Sequence Detail 49018 C57BL/6J ±  kb
transcript OTTMUST00000016280 VEGA | MGI Sequence Detail 5404 Not Applicable 
polypeptide OTTMUSP00000007454 VEGA | MGI Sequence Detail 1191 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(4) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(473 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR003395 RecF/RecN/SMC
InterPro IPR010935 SMCs flexible hinge
InterPro IPR024704 Structural maintenance of chromosomes protein
InterPro IPR027120 Structural maintenance of chromosomes Smc2
Protein Ontology PR:000015271 structural maintenance of chromosomes protein 2
References (Earliest) J:32076 Guthridge MA, et al., Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts. Oncogene. 1996 Mar 21;12(6):1267-78
(Latest) J:183026 Lee J, et al., Condensins I and II are essential for construction of bivalent chromosomes in mouse oocytes. Mol Biol Cell. 2011 Sep;22(18):3465-77
All references(45)
Other
accession IDs
MGD-MRK-33751, MGI:1915197, MGI:2140211, MGI:2140588

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory