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Ptafr Gene Detail
Summary
  • Symbol
    Ptafr
  • Name
    platelet-activating factor receptor
  • Synonyms
    PAFR, PAF receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:106066
    NCBI Gene: 19204
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:132291378-132309994 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 65.56 cM, cytoband D2.2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    330 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106066
 protein coding gene Chr4:132291378-132309994 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028875
 protein coding gene Chr4:134734680-134755175 (+)
A/J MGP_AJ_G0028834
 protein coding gene Chr4:129127988-129146979 (+)
AKR/J MGP_AKRJ_G0028787
 protein coding gene Chr4:132763122-132782949 (+)
BALB/cJ MGP_BALBcJ_G0028857
 protein coding gene Chr4:129747986-129767693 (+)
C3H/HeJ MGP_C3HHeJ_G0028571
 protein coding gene Chr4:133030126-133048383 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029299
 protein coding gene Chr4:139603110-139623059 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026570
 protein coding gene Chr4:122205731-122222034 (+)
CAST/EiJ MGP_CASTEiJ_G0028004
 protein coding gene Chr4:131105024-131125174 (+)
CBA/J MGP_CBAJ_G0028537
 protein coding gene Chr4:143173461-143196549 (+)
DBA/2J MGP_DBA2J_G0028686
 protein coding gene Chr4:129549021-129568057 (+)
FVB/NJ MGP_FVBNJ_G0028653
 protein coding gene Chr4:128404713-128425950 (+)
LP/J MGP_LPJ_G0028787
 protein coding gene Chr4:134887245-134908284 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028679
 protein coding gene Chr4:147764204-147788849 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029337
 protein coding gene Chr4:133179595-133202709 (+)
PWK/PhJ MGP_PWKPhJ_G0027725
 protein coding gene Chr4:126243690-126262371 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027551
 protein coding gene Chr4:129024599-129044867 (+)
WSB/EiJ MGP_WSBEiJ_G0028084
 protein coding gene Chr4:133351346-133370971 (+)



Homology
more
  • Human Ortholog
    PTAFR, platelet activating factor receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTAFR, platelet activating factor receptor
  • Synonyms
    PAFR
  • Links
    NCBI Gene ID: 5724
    neXtProt AC: NX_P25105
    UniProt: P25105

  • Chr Location
    1p35.3; chr1:28147166-28193936 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 4 genetic backgrounds
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this locus affects the immune response. Homozygotes have a marked reduction in systemic anaphylactic symptoms but are otherwise healthy. Further studies showed delayed elimination of parasites, and resistance to pneumonococcal pneumonia infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    9
  • cDNA Data
    8
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 19204 NCBI Gene Model | MGI Sequence Detail 18617 C57BL/6J ±  kb
transcript NM_001081211 RefSeq | MGI Sequence Detail 3660 ZRU/MplStud  
polypeptide Q62035 UniProt | EBI | MGI Sequence Detail 341 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    Genomic 1
    cDNA 8
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-33750
References
more
  • Summaries
    All 123
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 80
  • Earliest
    J:31955 Ishii S, et al., A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages. Biochem J. 1996 Mar 1;314(Pt 2):671-8
  • Latest
    J:346920 Dalmaso B, et al., Platelet-activating factor receptor (PAFR) regulates neuronal maturation and synaptic transmission during postnatal retinal development. Front Cell Neurosci. 2024;18:1343745
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory