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Ptafr Gene Detail
Summary
  • Symbol
    Ptafr
  • Name
    platelet-activating factor receptor
  • Synonyms
    PAFR, PAF receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:106066
    NCBI Gene: 19204
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:132564067-132582683 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 65.56 cM, cytoband D2.2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    330 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106066
protein coding gene Chr4:132564067-132582683 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028875
protein coding gene Chr4:134734680-134755175 (+)
A/J MGP_AJ_G0028834
protein coding gene Chr4:129127988-129146979 (+)
AKR/J MGP_AKRJ_G0028787
protein coding gene Chr4:132763122-132782949 (+)
BALB/cJ MGP_BALBcJ_G0028857
protein coding gene Chr4:129747986-129767693 (+)
C3H/HeJ MGP_C3HHeJ_G0028571
protein coding gene Chr4:133030126-133048383 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029299
protein coding gene Chr4:139603110-139623059 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026570
protein coding gene Chr4:122205731-122222034 (+)
CAST/EiJ MGP_CASTEiJ_G0028004
protein coding gene Chr4:131105024-131125174 (+)
CBA/J MGP_CBAJ_G0028537
protein coding gene Chr4:143173461-143196549 (+)
DBA/2J MGP_DBA2J_G0028686
protein coding gene Chr4:129549021-129568057 (+)
FVB/NJ MGP_FVBNJ_G0028653
protein coding gene Chr4:128404713-128425950 (+)
LP/J MGP_LPJ_G0028787
protein coding gene Chr4:134887245-134908284 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028679
protein coding gene Chr4:147764204-147788849 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029337
protein coding gene Chr4:133179595-133202709 (+)
PWK/PhJ MGP_PWKPhJ_G0027725
protein coding gene Chr4:126243690-126262371 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027551
protein coding gene Chr4:129024599-129044867 (+)
WSB/EiJ MGP_WSBEiJ_G0028084
protein coding gene Chr4:133351346-133370971 (+)



Homology
more
  • Human Ortholog
    PTAFR, platelet activating factor receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTAFR, platelet activating factor receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PAFR
  • Links
    NCBI Gene ID: 5724
    neXtProt AC: NX_P25105
    UniProt: P25105

  • Chr Location
    1p35.3; chr1:28147166-28193936 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Inactivation of this locus affects the immune response. Homozygotes have a marked reduction in systemic anaphylactic symptoms but are otherwise healthy. Further studies showed delayed elimination of parasites, and resistance to pneumonococcal pneumonia infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19204 NCBI Gene Model | MGI Sequence Detail 18617 C57BL/6J ±  kb
transcript NM_001081211 RefSeq | MGI Sequence Detail 3660 C57BL/6  
polypeptide Q62035 UniProt | EBI | MGI Sequence Detail 341 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    Genomic 1
    cDNA 8
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-33750
References
more
  • Summaries
    All 102
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 65
  • Earliest
    J:31955 Ishii S, et al., A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages. Biochem J. 1996 Mar 1;314(Pt 2):671-8
  • Latest
    J:251130 Patel PS, et al., CD36 and Platelet-Activating Factor Receptor Promote House Dust Mite Allergy Development. J Immunol. 2017 Aug 1;199(3):1184-1195

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory