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Ptafr Gene Detail
Summary
  • Symbol
    Ptafr
  • Name
    platelet-activating factor receptor
  • Synonyms
    PAFR, PAF receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:106066
    NCBI Gene: 19204
Location & Maps
more
  • Sequence Map
    Chr4:132564067-132582683 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18617 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 65.56 cM, cytoband D2.2
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    PTAFR, platelet activating factor receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTAFR, platelet activating factor receptor
    Orthology source: HomoloGene
  • Synonyms
    PAFR
  • Links
    NCBI Gene ID: 5724
    neXtProt AC: NX_P25105

  • Chr Location
    1p35-p34.3; chr1:28147166-28193936 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    2
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    4 involving Ptafr
  • Incidental Mutations
Inactivation of this locus affects the immune response. Homozygotes have a marked reduction in systemic anaphylactic symptoms but are otherwise healthy. Further studies showed delayed elimination of parasites, and resistance to pneumonococcal pneumonia infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009789 VEGA Gene Model | MGI Sequence Detail 18617 C57BL/6J ±  kb
transcript OTTMUST00000022676 VEGA | MGI Sequence Detail 3637 Not Applicable  
polypeptide OTTMUSP00000010350 VEGA | MGI Sequence Detail 341 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    330 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001501 platelet-activating factor receptor
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR002282 Platelet-activating factor receptor
Molecular
Reagents
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  • All nucleic 12
    Genomic 1
    cDNA 7
    Primer pair 3
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-33750
References
more
  • Summaries
    All 93
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 63
  • Earliest
    J:31955 Ishii S, et al., A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages. Biochem J. 1996 Mar 1;314(Pt 2):671-8
  • Latest
    J:216194 Ferracini M, et al., Topical Photodynamic Therapy Induces Systemic Immunosuppression via Generation of Platelet-Activating Factor Receptor Ligands. J Invest Dermatol. 2015 Jan;135(1):321-3

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory