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Psmc1 Gene Detail
Summary
  • Symbol
    Psmc1
  • Name
    protease (prosome, macropain) 26S subunit, ATPase 1
  • Synonyms
    P26s4, rpt2, Rpt2/S4, S4
  • Feature Type
    protein coding gene
  • IDs
    MGI:106054
    NCBI Gene: 19179
  • Gene Overview
    MyGene.info: PSMC1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:100110202-100123364 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 50.43 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106054
protein coding gene Chr12:100110154-100123405 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020015
protein coding gene Chr12:101570356-101584193 (+)
A/J MGP_AJ_G0019970
protein coding gene Chr12:97755662-97768715 (+)
AKR/J MGP_AKRJ_G0019946
protein coding gene Chr12:100394534-100408261 (+)
BALB/cJ MGP_BALBcJ_G0019956
protein coding gene Chr12:98099078-98112079 (+)
C3H/HeJ MGP_C3HHeJ_G0019758
protein coding gene Chr12:100938288-100951082 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020405
protein coding gene Chr12:104708359-104721152 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018019
protein coding gene Chr12:94726590-94740518 (+)
CAST/EiJ MGP_CASTEiJ_G0019304
protein coding gene Chr12:96049727-96062510 (+)
CBA/J MGP_CBAJ_G0019730
protein coding gene Chr12:108594591-108611190 (+)
DBA/2J MGP_DBA2J_G0019841
protein coding gene Chr12:97188956-97202819 (+)
FVB/NJ MGP_FVBNJ_G0019830
protein coding gene Chr12:95907671-95921705 (+)
LP/J MGP_LPJ_G0019917
protein coding gene Chr12:101409247-101425953 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019872
protein coding gene Chr12:112190751-112204647 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020434
protein coding gene Chr12:99968263-99982371 (+)
PWK/PhJ MGP_PWKPhJ_G0019068
protein coding gene Chr12:91821819-91835208 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018864
protein coding gene Chr12:94146609-94159431 (+)
WSB/EiJ MGP_WSBEiJ_G0019358
protein coding gene Chr12:100819155-100833618 (+)



Homology
more
  • Human Ortholog
    PSMC1, proteasome 26S subunit, ATPase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PSMC1, proteasome 26S subunit, ATPase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    P26S4, p56, S4
  • Links
    NCBI Gene ID: 5700
    neXtProt AC: NX_P62191
    UniProt: P62191

  • Chr Location
    14q32.11; chr14:90256550-90272625 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants are embryonic lethal. Conditional null in cortical neurons causes neurodegeneration and premature death in several different models.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19179 NCBI Gene Model | MGI Sequence Detail 13163 C57BL/6J ±  kb
    transcript NM_008947 RefSeq | MGI Sequence Detail 1502 C57BL/6  
    polypeptide P62192 UniProt | EBI | MGI Sequence Detail 440 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 200
      Genomic 3
      cDNA 194
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33738, MGI:2144794
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:30881 Hoyle J, et al., Genomic organization and mapping of the mouse P26s4 ATPase gene: a member of the remarkably conserved AAA gene family. Genomics. 1996 Jan 1;31(1):115-8
    • Latest
      J:262939 Geiszler PC, et al., Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons. Sci Rep. 2018 Mar 19;8(1):4833

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory