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Dtna
Gene Detail
 Symbol
Name
ID
Dtna
dystrobrevin alpha
MGI:106039
Synonyms 2210407P21Rik, 87K protein, A0, a-DB-1, adbn, alpha-dystrobrevin, Dtn
Feature Type protein coding gene
Genetic Map
Chromosome 18
12.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:23415415-23659714 bp, + strand
From NCBI annotation of GRCm38

  244300 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20362  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: distrobrevin
Gene Tree: Dtna

Human
homologs
Human Homolog DTNA, dystrobrevin, alpha
NCBI Gene ID 1837
neXtProt AC  NX_Q9Y4J8
Human Synonyms  D18S892E, DRP3, DTN, DTN-A, LVNC1
Human Chr (Location)  18q12; chr18:34493290-34891844 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DTNA
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(6) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted mutants exhibit skeletal and cardiac myopathies. Neuromuscular junctions appear to form normally, but their postnatal maturation is compromised. Dtna mutations do not increase the severity of Dmd or Utrn mutants whose products are also part of the dystrophin-glycoprotein complex.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Dtna interacts with 464 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Component axon, cell junction, ...
Function metal ion binding, PDZ domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (325)    Tissues (190)    Images (90)
Theiler Stages: 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 124
RNA in situ 139
Western blot 7
RT-PCR 55
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(3) cDNA(26) Primer pair(4)
Microarray probesets(9)
Other database
links
Ensembl Gene ModelENSMUSG00000024302 (Evidence)
Entrez Gene13527 (Evidence)
DFCITC1580290, TC1583715, TC1587820, TC1588833, TC1589021, TC1594198, TC1599521, TC1622870, TC1644790, TC1699827
DoTSDT.101360547, DT.101375169, DT.101375170, DT.101375171, DT.110776010, DT.50316348, DT.55117944, DT.55122692, DT.55282735, DT.60101497, DT.91359423, DT.91369218, DT.91393353
NIA Mouse Gene IndexU018474, U056950
Consensus CDS ProjectCCDS29094.1, CCDS50236.1
International Mouse Knockout Project StatusDtna
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13527 NCBI Gene Model | MGI Sequence Detail 244300 C57BL/6J ±  kb
transcript NM_001285813 RefSeq | MGI Sequence Detail 6376 C57BL/6 
polypeptide Q9D2N4 UniProt | EBI | MGI Sequence Detail 746 Not Applicable 

For the selected sequences
All sequences(170) RefSeq(72) UniProt(8)
Polymorphisms PCR(1) : SNPs within 2kb(1972 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017432 Distrobrevin
InterPro IPR015153 EF-hand domain, type 1
InterPro IPR015154 EF-hand domain, type 2
InterPro IPR011992 EF-hand-like domain
InterPro IPR000433 Zinc finger, ZZ-type
Protein Ontology PR:000006717 dystrobrevin alpha
Graphical View of Protein Domain Structure
References (Earliest) J:32261 Blake DJ, et al., Isoform diversity of dystrobrevin, the murine 87-kDa postsynaptic protein. J Biol Chem. 1996 Mar 29;271(13):7802-10
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(65)
Other
accession IDs
MGD-MRK-33723, MGI:1915272

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory