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Dtna Gene Detail
Summary
  • Symbol
    Dtna
  • Name
    dystrobrevin alpha
  • Synonyms
    2210407P21Rik, 87K protein, A0, a-DB-1, adbn, alpha-dystrobrevin, Dtn
  • Feature Type
    protein coding gene
  • IDs
    MGI:106039
    NCBI Gene: 13527
  • Gene Overview
    MyGene.info: DTNA
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr18:23415135-23659715 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      244581 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 12.08 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DTNA, dystrobrevin alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DTNA, dystrobrevin alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D18S892E, DRP3, DTN, DTN-A, LVNC1
  • Links
    NCBI Gene ID: 1837
    neXtProt AC: NX_Q9Y4J8
    UniProt: Q9Y4J8

  • Chr Location
    18q12.1; chr18:34493290-34891844 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human DTNA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted mutants exhibit skeletal and cardiac myopathies. Neuromuscular junctions appear to form normally, but their postnatal maturation is compromised. Dtna mutations do not increase the severity of Dmd or Utrn mutants whose products are also part of the dystrophin-glycoprotein complex.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    334
  • Tissues
    203
  • cDNA Data
    21
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024302 Ensembl Gene Model | MGI Sequence Detail 244581 C57BL/6J ±  kb
    transcript ENSMUST00000220904 Ensembl | MGI Sequence Detail 3860 Not Applicable  
    polypeptide ENSMUSP00000152288 Ensembl | MGI Sequence Detail 746 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2491 from dbSNP Build 142
    • PCR
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 3
      cDNA 26
      Primer pair 5

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-33723, MGI:1915272
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:28976 Madhavan R, et al., Interactions between dystrophin glycoprotein complex proteins. Biochemistry. 1995 Sep 26;34(38):12204-9
    • Latest
      J:246102 Gingras J, et al., Alpha-Dystrobrevin-1 recruits Grb2 and alpha-catulin to organize neurotransmitter receptors at the neuromuscular junction. J Cell Sci. 2016 Mar 01;129(5):898-911
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory