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Dtna Gene Detail
Summary
  • Symbol
    Dtna
  • Name
    dystrobrevin alpha
  • Synonyms
    2210407P21Rik, 87K protein, A0, a-DB-1, adbn, alpha-dystrobrevin, Dtn
  • Feature Type
    protein coding gene
  • IDs
    MGI:106039
    NCBI Gene: 13527
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:23548192-23792772 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 12.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1969 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106039
 protein coding gene Chr18:23443063-23792776 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024192
 protein coding gene Chr18:21129015-21375999 (+)
A/J MGP_AJ_G0024157
 protein coding gene Chr18:20523051-20797808 (+)
AKR/J MGP_AKRJ_G0024126
 protein coding gene Chr18:21187489-21434929 (+)
BALB/cJ MGP_BALBcJ_G0024157
 protein coding gene Chr18:20600306-20846905 (+)
C3H/HeJ MGP_C3HHeJ_G0023925
 protein coding gene Chr18:21096936-21346410 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024599
 protein coding gene Chr18:22050554-22301941 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022041
 protein coding gene Chr18:20425047-20667722 (+)
CAST/EiJ MGP_CASTEiJ_G0023399
 protein coding gene Chr18:20893129-21146377 (+)
CBA/J MGP_CBAJ_G0023893
 protein coding gene Chr18:22638237-22899547 (+)
DBA/2J MGP_DBA2J_G0024025
 protein coding gene Chr18:20231497-20475517 (+)
FVB/NJ MGP_FVBNJ_G0023991
 protein coding gene Chr18:19972552-20220974 (+)
LP/J MGP_LPJ_G0024106
 protein coding gene Chr18:21280215-21536374 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024019
 protein coding gene Chr18:23658984-23929505 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024647
 protein coding gene Chr18:20932582-21181538 (+)
PWK/PhJ MGP_PWKPhJ_G0023143
 protein coding gene Chr18:20347189-20599621 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022952
 protein coding gene Chr18:21147201-21409689 (+)
WSB/EiJ MGP_WSBEiJ_G0023463
 protein coding gene Chr18:20830800-21081344 (+)



Homology
more
  • Human Ortholog
    DTNA, dystrobrevin alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DTNA, dystrobrevin alpha
  • Synonyms
    D18S892E, DRP3, DTN, DTN-A, LVNC1
  • Links
    NCBI Gene ID: 1837
    neXtProt AC: NX_Q9Y4J8
    UniProt: Q9Y4J8

  • Chr Location
    18q12.1; chr18:34493290-34891844 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with human DTNA associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous targeted mutants exhibit skeletal and cardiac myopathies. Neuromuscular junctions appear to form normally, but their postnatal maturation is compromised. Dtna mutations do not increase the severity of Dmd or Utrn mutants whose products are also part of the dystrophin-glycoprotein complex.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1040
  • Tissues
    203
  • cDNA Data
    23
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024302 Ensembl Gene Model | MGI Sequence Detail 244581 C57BL/6J ±  kb
    transcript ENSMUST00000220904 Ensembl | MGI Sequence Detail 3860 Not Applicable  
    polypeptide ENSMUSP00000152288 Ensembl | MGI Sequence Detail 746 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 3
      cDNA 28
      Primer pair 5

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-33723, MGI:1915272
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 10
      Phenotypes 25
    • Earliest
      J:28976 Madhavan R, et al., Interactions between dystrophin glycoprotein complex proteins. Biochemistry. 1995 Sep 26;34(38):12204-9
    • Latest
      J:327902 Hawkes CA, et al., alpha-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression. Acta Neuropathol Commun. 2022 Aug 31;10(1):127
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/15/2022
    MGI 6.22     		The Jackson Laboratory