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Lrrn1 Gene Detail
Summary
  • Symbol
    Lrrn1
  • Name
    leucine rich repeat protein 1, neuronal
  • Synonyms
    2810047E21Rik, NLRR-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106038
    NCBI Gene: 16979
  • Gene Overview
    MyGene.info: LRRN1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:107529768-107570214 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 49.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    406 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106038
protein coding gene Chr6:107529726-107570228 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031097
protein coding gene Chr6:109784390-109824758 (+)
A/J MGP_AJ_G0031066
protein coding gene Chr6:105593815-105634529 (+)
AKR/J MGP_AKRJ_G0030997
protein coding gene Chr6:108447634-108490340 (+)
BALB/cJ MGP_BALBcJ_G0031077
protein coding gene Chr6:105546774-105587034 (+)
C3H/HeJ MGP_C3HHeJ_G0030631
protein coding gene Chr6:75848377-75890319 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031536
protein coding gene Chr6:112662320-112702819 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028700
protein coding gene Chr6:102990931-103028598 (+)
CAST/EiJ MGP_CASTEiJ_G0030184
protein coding gene Chr6:108844365-108886979 (+)
CBA/J MGP_CBAJ_G0030763
protein coding gene Chr6:117035839-117076172 (+)
DBA/2J MGP_DBA2J_G0030916
protein coding gene Chr6:104737151-104778150 (+)
FVB/NJ MGP_FVBNJ_G0030870
protein coding gene Chr6:103802773-103846292 (+)
LP/J MGP_LPJ_G0030996
protein coding gene Chr6:109834426-109876359 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030904
protein coding gene Chr6:121234323-121277320 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031563
protein coding gene Chr6:108440159-108482626 (+)
PWK/PhJ MGP_PWKPhJ_G0029900
protein coding gene Chr6:103697777-103739243 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029728
protein coding gene Chr6:107254523-107297498 (+)
WSB/EiJ MGP_WSBEiJ_G0030268
protein coding gene Chr6:108959588-109000161 (+)



Homology
more
  • Human Ortholog
    LRRN1, leucine rich repeat neuronal 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRRN1, leucine rich repeat neuronal 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FIGLER3, NLRR-1
  • Links
    NCBI Gene ID: 57633
    neXtProt AC: NX_Q6UXK5
    UniProt: Q6UXK5

  • Chr Location
    3p26.2; chr3:3799431-3849834 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32036
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRRN1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutant mice exhibited decreased exploratory activity and the female mutants exhibited an increased anxiety-like response during open field testing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034648 Ensembl Gene Model | MGI Sequence Detail 40447 C57BL/6J ±  kb
transcript ENSMUST00000049285 Ensembl | MGI Sequence Detail 3700 Not Applicable  
polypeptide ENSMUSP00000037096 Ensembl | MGI Sequence Detail 716 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 12
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-33722, MGI:1919960
References
more
  • Summaries
    All 44
    Developmental Gene Expression 14
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:31287 Taguchi A, et al., Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system. Brain Res Mol Brain Res. 1996 Jan;35(1-2):31-40
  • Latest
    J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory