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Lrrn2
Gene Detail
 Symbol
Name
ID
Lrrn2
leucine rich repeat protein 2, neuronal
MGI:106037
Synonyms 5730406J09Rik, NLRR-2
Feature Type protein coding gene
Genetic Map
Chromosome 1
57.69 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:132880273-132940005 bp, + strand
From VEGA annotation of GRCm38

  59733 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21274  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Lrrn2

Human
homologs
Human Homolog LRRN2, leucine rich repeat neuronal 2
NCBI Gene ID 10446
neXtProt AC  NX_O75325
Human Synonyms  FIGLER7, GAC1, LRANK1, LRRN5
Human Chr (Location)  1q32.1; chr1:204617170-204685469 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibited numerous neurological abnormalities when compared with controls.
 
Interactions
Lrrn2 interacts with 106 markers (Mir22, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process biological_process
Component cellular_component
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (229)    Tissues (72)    Images (32)
Theiler Stages: 17, 23, 26, 28
Assay TypeResults
RNA in situ 229
cDNA source data(36)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(36) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000029281 (Evidence)
Ensembl Gene ModelENSMUSG00000026443 (Evidence)
Entrez Gene16980 (Evidence)
UniGene39640
DFCITC1578152, TC1722815
DoTSDT.101737654
NIA Mouse Gene IndexU040573
Consensus CDS ProjectCCDS15289.1
International Mouse Knockout Project StatusLrrn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029281 VEGA Gene Model | MGI Sequence Detail 59733 C57BL/6J ±  kb
transcript OTTMUST00000072558 VEGA | MGI Sequence Detail 3428 Not Applicable 
polypeptide OTTMUSP00000037388 VEGA | MGI Sequence Detail 730 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(474 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000030422 leucine-rich repeat neuronal protein 2
References (Earliest) J:31287 Taguchi A, et al., Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system. Brain Res Mol Brain Res. 1996 Jan;35(1-2):31-40
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)
Other
accession IDs
MGD-MRK-33721, MGI:1925383

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory