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Lrrn2 Gene Detail
Summary
  • Symbol
    Lrrn2
  • Name
    leucine rich repeat protein 2, neuronal
  • Synonyms
    5730406J09Rik, NLRR-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106037
    NCBI Gene: 16980
  • Gene Overview
    MyGene.info: LRRN2
Location & Maps
more
  • Sequence Map
    Chr1:132880273-132940005 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59733 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 57.69 cM, cytoband E4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LRRN2, leucine rich repeat neuronal 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LRRN2, leucine rich repeat neuronal 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FIGLER7, GAC1, LRANK1, LRRN5
  • Links
    NCBI Gene ID: 10446
    neXtProt AC: NX_O75325

  • Chr Location
    1q32.1; chr1:204617170-204685733 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    2
  • Gene trapped
    11
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    3 involving Lrrn2
  • Incidental Mutations
Homozygous mutant mice exhibited numerous neurological abnormalities when compared with controls.
Gene Ontology
(GO)
Classifications
less
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029281 VEGA Gene Model | MGI Sequence Detail 59733 C57BL/6J ±  kb
transcript OTTMUST00000072558 VEGA | MGI Sequence Detail 3428 Not Applicable  
polypeptide OTTMUSP00000037388 VEGA | MGI Sequence Detail 730 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    474 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 36
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-33721, MGI:1925383
References
more
  • Summaries
    All 32
    Developmental Gene Expression 7
    Phenotypes 11
  • Earliest
    J:31287 Taguchi A, et al., Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system. Brain Res Mol Brain Res. 1996 Jan;35(1-2):31-40
  • Latest
    J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory