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Lrrn3 Gene Detail
Summary
  • Symbol
    Lrrn3
  • Name
    leucine rich repeat protein 3, neuronal
  • Synonyms
    NLRR-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106036
    NCBI Gene: 16981
  • Gene Overview
    MyGene.info: LRRN3
Location & Maps
more
  • Sequence Map
    Chr12:41451673-41485751 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34079 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 18.94 cM, cytoband B3
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    LRRN3, leucine rich repeat neuronal 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRRN3, leucine rich repeat neuronal 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FIGLER5, NLRR3, NLRR-3
  • Links
    NCBI Gene ID: 54674
    neXtProt AC: NX_Q9H3W5

  • Chr Location
    7q31.1; chr7:111091006-111125454 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 36315
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LRRN3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutant mice exhibited increased mean percent body fat and male homozygous mutant mice exhibited enhanced glucose tolerance when compared with controls.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036295 Ensembl Gene Model | MGI Sequence Detail 34079 C57BL/6J ±  kb
transcript ENSMUST00000043884 Ensembl | MGI Sequence Detail 3180 Not Applicable  
polypeptide ENSMUSP00000043818 Ensembl | MGI Sequence Detail 707 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    284 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33720
References
more
  • Summaries
    All 31
    Developmental Gene Expression 11
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:31449 Taniguchi H, et al., Cloning and expression of a novel gene for a protein with leucine-rich repeats in the developing mouse nervous system. Brain Res Mol Brain Res. 1996 Feb;36(1):45-52
  • Latest
    J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory