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Tfap2c Gene Detail
Summary
  • Symbol
    Tfap2c
  • Name
    transcription factor AP-2, gamma
  • Synonyms
    Ap-2.2, AP2gamma, Stra2, Tcfap2c
  • Feature Type
    protein coding gene
  • IDs
    MGI:106032
    NCBI Gene: 21420
  • Gene Overview
    MyGene.info: TFAP2C
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:172549593-172558622 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9030 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 94.87 cM, cytoband H3-H4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TFAP2C, transcription factor AP-2 gamma
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TFAP2C, transcription factor AP-2 gamma
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AP2-GAMMA, ERF1, hAP-2g, TFAP2G
  • Links
    NCBI Gene ID: 7022
    neXtProt AC: NX_Q92754
    UniProt: Q92754

  • Chr Location
    20q13.31; chr20:56629302-56639283 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2423
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TFAP2C
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 4 genetic backgrounds
    27 phenotypes from multigenic genotypes
    4 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to embryonic growth retardation, failure to establish a normal maternal-embryonic interface, malformed extra-embryonic tissues, and early embryonic lethality due to placental malfunction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016248 VEGA Gene Model | MGI Sequence Detail 9030 C57BL/6J ±  kb
    transcript OTTMUST00000040418 VEGA | MGI Sequence Detail 2985 Not Applicable  
    polypeptide OTTMUSP00000018057 VEGA | MGI Sequence Detail 513 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      87 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR004979 Transcription factor AP-2
      IPR013854 Transcription factor AP-2, C-terminal
      IPR008123 Transcription factor AP-2 gamma
    Molecular
    Reagents
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    • All nucleic 112
      Genomic 1
      cDNA 104
      Primer pair 6
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
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    MGD-MRK-33716, MGD-MRK-36502, MGI:107922, MGI:2138767
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 46
      Gene Ontology 17
      Phenotypes 18
    • Earliest
      J:7873 Keitges E, et al., X-linkage of steroid sulphatase in the mouse is evidence for a functional Y-linked allele. Nature. 1985 May 16-22;315(6016):226-7
    • Latest
      J:249804 Haushalter C, et al., Retinoic acid controls early neurogenesis in the developing mouse cerebral cortex. Dev Biol. 2017 Oct 1;430(1):129-141

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    06/05/2018
    MGI 6.12
    The Jackson Laboratory