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Tfap2c Gene Detail
Summary
  • Symbol
    Tfap2c
  • Name
    transcription factor AP-2, gamma
  • Synonyms
    Ap-2.2, AP2gamma, Stra2, Tcfap2c
  • Feature Type
    protein coding gene
  • IDs
    MGI:106032
    NCBI Gene: 21420
  • Gene Overview
    MyGene.info: TFAP2C
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:172549593-172558622 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 94.87 cM, cytoband H3-H4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106032
protein coding gene Chr2:172545679-172558622 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026948
protein coding gene Chr2:178738634-178749261 (+)
A/J MGP_AJ_G0026915
protein coding gene Chr2:171248940-171258342 (+)
AKR/J MGP_AKRJ_G0026886
protein coding gene Chr2:176418679-176426730 (+)
BALB/cJ MGP_BALBcJ_G0026924
protein coding gene Chr2:171647239-171655991 (+)
C3H/HeJ MGP_C3HHeJ_G0026666
protein coding gene Chr2:176778493-176779895 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027371
protein coding gene Chr2:183896352-183910162 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024741
protein coding gene Chr2:164497703-164506651 (+)
CAST/EiJ MGP_CASTEiJ_G0026124
protein coding gene Chr2:177459015-177470671 (+)
CBA/J MGP_CBAJ_G0026643
protein coding gene Chr2:190772165-190773567 (+)
DBA/2J MGP_DBA2J_G0026781
protein coding gene Chr2:170344453-170354372 (+)
FVB/NJ MGP_FVBNJ_G0026747
protein coding gene Chr2:168946243-168955656 (+)
LP/J MGP_LPJ_G0026882
protein coding gene Chr2:178665492-178676387 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026766
protein coding gene Chr2:193753295-193765971 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027428
protein coding gene Chr2:176389626-176409029 (+)
PWK/PhJ MGP_PWKPhJ_G0025861
protein coding gene Chr2:170118979-170128293 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025661
protein coding gene Chr2:175390541-175399430 (+)
WSB/EiJ MGP_WSBEiJ_G0026197
protein coding gene Chr2:177369105-177382809 (+)



Homology
more
  • Human Ortholog
    TFAP2C, transcription factor AP-2 gamma
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TFAP2C, transcription factor AP-2 gamma
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AP2-GAMMA, ERF1, hAP-2g, TFAP2G
  • Links
    NCBI Gene ID: 7022
    neXtProt AC: NX_Q92754
    UniProt: Q92754

  • Chr Location
    20q13.31; chr20:56629302-56639283 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2423
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TFAP2C
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 4 genetic backgrounds
    27 phenotypes from multigenic genotypes
    4 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to embryonic growth retardation, failure to establish a normal maternal-embryonic interface, malformed extra-embryonic tissues, and early embryonic lethality due to placental malfunction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028640 Ensembl Gene Model | MGI Sequence Detail 9030 C57BL/6J ±  kb
    transcript ENSMUST00000099058 Ensembl | MGI Sequence Detail 2985 Not Applicable  
    polypeptide ENSMUSP00000096657 Ensembl | MGI Sequence Detail 513 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR004979 Transcription factor AP-2
      IPR013854 Transcription factor AP-2, C-terminal
      IPR008123 Transcription factor AP-2 gamma
    Molecular
    Reagents
    less
    • All nucleic 114
      Genomic 1
      cDNA 105
      Primer pair 7
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33716, MGD-MRK-36502, MGI:107922, MGI:2138767
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 49
      Gene Ontology 17
      Phenotypes 18
    • Earliest
      J:7873 Keitges E, et al., X-linkage of steroid sulphatase in the mouse is evidence for a functional Y-linked allele. Nature. 1985 May 16-22;315(6016):226-7
    • Latest
      J:263083 Jain S, et al., AP-2epsilon Expression in Developing Retina: Contributing to the Molecular Diversity of Amacrine Cells. Sci Rep. 2018 Feb 21;8(1):3386

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory