About   Help   FAQ
Tfap2c Gene Detail
Summary
  • Symbol
    Tfap2c
  • Name
    transcription factor AP-2, gamma
  • Synonyms
    Ap-2.2, AP2gamma, Stra2, Tcfap2c
  • Feature Type
    protein coding gene
  • IDs
    MGI:106032
    NCBI Gene: 21420
  • Gene Overview
    MyGene.info: TFAP2C
Location & Maps
more
  • Sequence Map
    Chr2:172549593-172558622 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9030 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 94.87 cM, cytoband H3-H4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TFAP2C, transcription factor AP-2 gamma
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TFAP2C, transcription factor AP-2 gamma
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AP2-GAMMA, ERF1, hAP-2g, TFAP2G
  • Links
    NCBI Gene ID: 7022
    neXtProt AC: NX_Q92754

  • Chr Location
    20q13.2; chr20:56629302-56639283 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2423
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TFAP2C
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 4 alleles in 4 genetic backgrounds
    27 phenotypes from multigenic genotypes
    4 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    3
  • Targeted
    7
  • Incidental Mutations
Homozygous inactivation of this gene leads to embryonic growth retardation, failure to establish a normal maternal-embryonic interface, malformed extra-embryonic tissues, and early embryonic lethality due to placental malfunction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016248 VEGA Gene Model | MGI Sequence Detail 9030 C57BL/6J ±  kb
transcript OTTMUST00000040418 VEGA | MGI Sequence Detail 2985 Not Applicable  
polypeptide OTTMUSP00000018057 VEGA | MGI Sequence Detail 513 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    87 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000016265 transcription factor AP-2 gamma
  • InterPro Domains
    IPR004979 Transcription factor AP-2
    IPR013854 Transcription factor AP-2, C-terminal
    IPR008123 Transcription factor AP-2 gamma
Molecular
Reagents
less
  • All nucleic 112
    Genomic 1
    cDNA 105
    Primer pair 6

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-33716, MGD-MRK-36502, MGI:107922, MGI:2138767
References
more
  • Summaries
    All 82
    Developmental Gene Expression 41
    Gene Ontology 17
    Phenotypes 17
  • Earliest
    J:7873 Keitges E, et al., X-linkage of steroid sulphatase in the mouse is evidence for a functional Y-linked allele. Nature. 1985 May 16-22;315(6016):226-7
  • Latest
    J:227118 Latos PA, et al., Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Genes Dev. 2015 Dec 1;29(23):2435-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/12/2016
MGI 6.04
The Jackson Laboratory