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Tfap2c
Gene Detail
Symbol

Name
ID
Tfap2c
transcription factor AP-2, gamma
MGI:106032
Synonyms
Ap-2.2, AP2gamma, Stra2, Tcfap2c
Feature Type
protein coding gene
Genetic Map
Chromosome 2
94.87 cM, cytoband H3-H4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:172549593-172558622 bp, + strand
From VEGA annotation of GRCm38

  9030 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2423  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TFAP2C
Gene Tree: Tfap2c

Human
homologs
TFAP2C, transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7022
neXtProt AC: NX_Q92754

Human Synonyms: AP2-GAMMA, ERF1, hAP-2g, TFAP2G

Human Chr (Location): 20q13.2; chr20:56629302-56639283 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(3) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to embryonic growth retardation, failure to establish a normal maternal-embryonic interface, malformed extra-embryonic tissues, and early embryonic lethality due to placental malfunction.
 
Phenotype Images(4)
Interactions
Tfap2c interacts with 173 markers (Mir7-2, Mir7b, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process cell differentiation, cerebral cortex development, ...
Component nucleus
Function core promoter binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (38 records)
Data Summary: Results (267)    Tissues (200)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 220
Western blot 1
RT-PCR 46
cDNA source data(104)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TFAP2C ; Xenbase tfap2c ; ZFIN tfap2c    NEW 
Molecular
reagents
All nucleic(112) Genomic(1) cDNA(105) Primer pair(6)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016248 (Evidence)
Ensembl Gene Model ENSMUSG00000028640 (Evidence)
Entrez Gene 21420 (Evidence)
UniGene 3629
DFCI TC1626798, TC1639581, TC1591024, TC1576915
DoTS DT.101220572, DT.94316946, DT.529551, DT.101382006, DT.99847974
NIA Mouse Gene Index U002903
Consensus CDS Project CCDS17135.1, CCDS50810.1
International Mouse Phenotyping Consortium Status Tfap2c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016248 VEGA Gene Model | MGI Sequence Detail 9030 C57BL/6J ±  kb
transcript OTTMUST00000040418 VEGA | MGI Sequence Detail 2985 Not Applicable 
polypeptide OTTMUSP00000018057 VEGA | MGI Sequence Detail 513 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004979 Transcription factor AP-2
InterPro IPR013854 Transcription factor AP-2, C-terminal
InterPro IPR008123 Transcription factor AP-2 gamma
Protein Ontology PR:000016265 transcription factor AP-2 gamma
References
(Earliest) J:7873 Keitges E, et al., X-linkage of steroid sulphatase in the mouse is evidence for a functional Y-linked allele. Nature. 1985 May 16-22;315(6016):226-7
(Latest) J:221425 Cao Z, et al., Transcription factor AP-2gamma induces early Cdx2 expression and represses HIPPO signaling to specify the trophectoderm lineage. Development. 2015 May 1;142(9):1606-15
All references(80)
Other
accession IDs
MGD-MRK-33716, MGD-MRK-36502, MGI:107922, MGI:2138767

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory