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Rhoc Gene Detail
Summary
  • Symbol
    Rhoc
  • Name
    ras homolog family member C
  • Synonyms
    Arh9, Arhc
  • Feature Type
    protein coding gene
  • IDs
    MGI:106028
    NCBI Gene: 11853
  • Gene Overview
    MyGene.info: RHOC
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:104789034-104794459 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 45.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106028
protein coding gene Chr3:104788375-104794459 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027710
protein coding gene Chr3:106112311-106117806 (+)
A/J MGP_AJ_G0027670
protein coding gene Chr3:102730924-102736398 (+)
AKR/J MGP_AKRJ_G0027635
protein coding gene Chr3:105257080-105262565 (+)
BALB/cJ MGP_BALBcJ_G0027682
protein coding gene Chr3:102515910-102521396 (+)
C3H/HeJ MGP_C3HHeJ_G0027412
protein coding gene Chr3:105638615-105644058 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028126
protein coding gene Chr3:110076271-110081768 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025466
protein coding gene Chr3:98840768-98847128 (+)
CAST/EiJ MGP_CASTEiJ_G0026868
protein coding gene Chr3:104753570-104759250 (+)
CBA/J MGP_CBAJ_G0027387
protein coding gene Chr3:113823290-113828738 (+)
DBA/2J MGP_DBA2J_G0027529
protein coding gene Chr3:101984756-101990241 (+)
FVB/NJ MGP_FVBNJ_G0027497
protein coding gene Chr3:99906087-99912796 (+)
LP/J MGP_LPJ_G0027636
protein coding gene Chr3:107493370-107498784 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027527
protein coding gene Chr3:119946924-119952394 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028181
protein coding gene Chr3:104817408-104822861 (+)
PWK/PhJ MGP_PWKPhJ_G0026594
protein coding gene Chr3:101760692-101766330 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026415
protein coding gene Chr3:102854147-102859539 (+)
WSB/EiJ MGP_WSBEiJ_G0026948
protein coding gene Chr3:105395478-105401147 (+)



Homology
more
  • Human Ortholog
    RHOC, ras homolog family member C
  • Vertebrate Orthologs
    12
  • Human Ortholog
    RHOC, ras homolog family member C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARH9, ARHC, H9, RHOH9
  • Links
    NCBI Gene ID: 389
    neXtProt AC: NX_P08134
    UniProt: P08134

  • Chr Location
    1p13.2; chr1:112701127-112707403 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutation in this gene results in no abnormal phenotype, except for reduced stress fiber formation in serum starved fibroblasts. However, in combination with Tg(MMTV-PyVT)634Mul mice, metastatic potential of tumors and tumor cell motility are decreased.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11853 NCBI Gene Model | MGI Sequence Detail 5426 C57BL/6J ±  kb
transcript NM_001291859 RefSeq | MGI Sequence Detail 1092 C57BL/6  
polypeptide Q62159 UniProt | EBI | MGI Sequence Detail 193 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 137
    cDNA 137

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-33711, MGI:2139675
References
more
  • Summaries
    All 54
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 11
    Phenotypes 12
  • Earliest
    J:4309 Miki T, et al., Oncogene ect2 is related to regulators of small GTP-binding proteins [published erratum appears in Nature 1993 Aug 19;364(6439):737]. Nature. 1993 Apr 1;362(6419):462-5
  • Latest
    J:250125 Escamilla CO, et al., Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature. 2017 Nov 9;551(7679):227-231

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory