About   Help   FAQ
Rhoc Gene Detail
Summary
  • Symbol
    Rhoc
  • Name
    ras homolog family member C
  • Synonyms
    Arh9, Arhc
  • Feature Type
    protein coding gene
  • IDs
    MGI:106028
    NCBI Gene: 11853
  • Gene Overview
    MyGene.info: RHOC
Location & Maps
more
  • Sequence Map
    Chr3:104788375-104794459 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6085 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 45.86 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RHOC, ras homolog family member C
  • Vertebrate Orthologs
    12
  • Human Ortholog
    RHOC, ras homolog family member C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARH9, ARHC, H9, RHOH9
  • Links
    NCBI Gene ID: 389
    neXtProt AC: NX_P08134

  • Chr Location
    1p13.2; chr1:112701127-112707403 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Gene trapped
    18
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Rhoc
  • Incidental Mutations
Homozygous null mutation in this gene results in no abnormal phenotype, except for reduced stress fiber formation in serum starved fibroblasts. However, in combination with Tg(MMTV-PyVT)634Mul mice, metastatic potential of tumors and tumor cell motility are decreased.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022218 VEGA Gene Model | MGI Sequence Detail 6085 C57BL/6J ±  kb
transcript OTTMUST00000132447 VEGA | MGI Sequence Detail 877 Not Applicable  
polypeptide OTTMUSP00000070610 VEGA | MGI Sequence Detail 193 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    46 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 136
    cDNA 136

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-33711, MGI:2139675
References
more
  • Summaries
    All 45
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:4309 Miki T, et al., Oncogene ect2 is related to regulators of small GTP-binding proteins [published erratum appears in Nature 1993 Aug 19;364(6439):737]. Nature. 1993 Apr 1;362(6419):462-5
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory