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Gucy2g
Gene Detail
 Symbol
Name
ID
Gucy2g
guanylate cyclase 2g
MGI:106025
Synonyms 2410077I05Rik, GC-G
Feature Type protein coding gene
Genetic Map
Chromosome 19
51.18 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:55198297-55241236 bp, - strand
From VEGA annotation of GRCm38

  42940 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:44544  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 zebrafish

Protein SuperFamily: membrane-bound guanylate cyclase
Gene Tree: Gucy2g

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation are viable and fertile with no gross abnormalities and are protected against acute ischemia induced renal injury.
 
Interactions
Gucy2g interacts with 82 markers (Mir1a-1, Mir1a-2, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cGMP biosynthetic process, cyclic nucleotide biosynthetic process, ...
Component external side of plasma membrane, integral component of membrane, ...
Function ATP binding, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (38)    Tissues (24)    Images (1)
Theiler Stages: 10, 18, 20, 23, 25, 28
Assay TypeResults
Northern blot 16
RT-PCR 22
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(3) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000033407 (Evidence)
Ensembl Gene ModelENSMUSG00000055523 (Evidence)
Entrez Gene73707 (Evidence)
UniGene489987
DFCITC1598443
DoTSDT.101714181
NIA Mouse Gene IndexU039162
EC4.6.1.2
Consensus CDS ProjectCCDS38026.1
International Mouse Knockout Project StatusGucy2g
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033407 VEGA Gene Model | MGI Sequence Detail 42940 C57BL/6J ±  kb
transcript OTTMUST00000083872 VEGA | MGI Sequence Detail 3690 Not Applicable 
polypeptide OTTMUSP00000045123 VEGA | MGI Sequence Detail 1100 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(278 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR001170 Natriuretic peptide receptor
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000008397 guanylate cyclase 2G
References (Earliest) J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
(Latest) J:197858 Hanke W, et al., Odorant-evoked electrical responses in Grueneberg ganglion neurons rely on cGMP-associated signaling proteins. Neurosci Lett. 2013 Feb 28;539:38-42
All references(36)
Other
accession IDs
MGD-MRK-33707, MGI:1920957

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory