Gucy2g
Gene Detail

Symbol Name ID

Gucy2g guanylate cyclase 2g MGI:106025

Synonyms

2410077I05Rik, GC-G

Feature Type

protein coding gene

Genetic Map

Chromosome 19

51.18 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr19:55198297-55241236 bp, - strand From VEGA annotation of GRCm38   42940 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:44544  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: membrane-bound guanylate cyclase
Gene Tree: Gucy2g

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a null mutation are viable and fertile with no gross abnormalities and are protected against acute ischemia induced renal injury.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	cGMP biosynthetic process, cyclic nucleotide biosynthetic process, ...
Component	external side of plasma membrane, integral to membrane, ...
Function	ATP binding, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (38)    Tissues (24)    Images (1)
Theiler Stages: 10, 18, 20, 23, 25, 28

Assay Type	Results
Northern blot	16
RT-PCR	22

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(3) Primer pair(3)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000033407 (Evidence)
Ensembl Gene Model	ENSMUSG00000055523 (Evidence)
Entrez Gene	73707 (Evidence)
UniGene	159051
DFCI	TC1598443
DoTS	DT.101714181
NIA Mouse Gene Index	U039162
EC	4.6.1.2
Consensus CDS Project	CCDS38026.1
International Mouse Knockout Project Status	Gucy2g

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033407	VEGA Gene Model | MGI Sequence Detail	42940	C57BL/6J
transcript	OTTMUST00000083872	VEGA | MGI Sequence Detail	3690	Not Applicable
polypeptide	OTTMUSP00000045123	VEGA | MGI Sequence Detail	1100	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

PCR(1) : SNPs(246 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro	IPR018297	Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR001170	Natriuretic peptide receptor
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology	PR:000008397	guanylate cyclase 2G

References

(Earliest) J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)

Other accession IDs

MGD-MRK-33707, MGI:1920957