St8sia3
Gene Detail

Symbol Name ID

St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 MGI:106019

Synonyms

Siat8c, ST8SiaIII

Feature Type

protein coding gene

Genetic Map

Chromosome 18

37.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:64254359-64276146 bp, + strand From VEGA annotation of GRCm38   21788 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8285  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Protein SuperFamily: sialyltransferase
Gene Tree: St8sia3

Human homologs

Human Homolog		ST8SIA3, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
NCBI Gene ID		51046
neXtProt AC		NX_O43173
Human Synonyms		SIAT8C, ST8SiaIII
Human Chr (Location)		18q21.31; chr18:55019721-55036162 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	ganglioside biosynthetic process, glycoprotein metabolic process, ...
Component	Golgi apparatus, integral to Golgi membrane, ...
Function	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity, sialyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (35)    Tissues (18)    Images (2)
Theiler Stages: 12, 20, 22, 24, 26, 28

Assay Type	Results
Northern blot	15
RT-PCR	20

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(44) Genomic(1) cDNA(41) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000028204 (Evidence)
Ensembl Gene Model	ENSMUSG00000056812 (Evidence)
Entrez Gene	20451 (Evidence)
UniGene	252110
DFCI	TC1583121, TC1605562, TC1633508
DoTS	DT.50315544
NIA Mouse Gene Index	U018814
EC	2.4.99.-
Consensus CDS Project	CCDS29301.1
International Mouse Knockout Project Status	St8sia3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028204	VEGA Gene Model | MGI Sequence Detail	21788	C57BL/6J
transcript	OTTMUST00000069864	VEGA | MGI Sequence Detail	6282	Not Applicable
polypeptide	OTTMUSP00000035540	VEGA | MGI Sequence Detail	380	Not Applicable

All sequences(36) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(35 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001675	Glycosyl transferase, family 29
InterPro	IPR012163	Sialyltransferase
Protein Ontology	PR:000015697	sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase

References

(Earliest) J:26814 Yoshida Y, et al., Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain. J Biol Chem. 1995 Jun 16;270(24):14628-33
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)

Other accession IDs

MGD-MRK-33701, MGI:2147270