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St8sia4
Gene Detail
 Symbol
Name
ID
St8sia4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
MGI:106018
Synonyms PST, PST-1, Siat8d, ST8SiaIV
Feature Type protein coding gene
Genetic Map
Chromosome 1
47.76 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:95587684-95667594 bp, - strand
From Ensembl annotation of GRCm38

  79911 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4147  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: sialyltransferase
Gene Tree: St8sia4

Human
homologs
Human Homolog ST8SIA4, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
NCBI Gene ID 7903
neXtProt AC  NX_Q92187
Human Synonyms  PST, PST1, SIAT8D, ST8SIA-IV
Human Chr (Location)  5q21; chr5:100806935-100903285 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null adult mice exhibit impaired long term potentiation and impaired long term depression in hippocampal CA1 synapses.
 
Interactions
St8sia4 interacts with 425 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process ganglioside biosynthetic process, N-glycan processing, ...
Component Golgi apparatus, integral component of Golgi membrane, ...
Function alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity, lytic endotransglycosylase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (109)    Tissues (27)    Images (21)
Theiler Stages: 12, 14, 15, 20, 23, 28
Assay TypeResults
RNA in situ 94
RT-PCR 15
cDNA source data(38)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) Genomic(4) cDNA(38) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000040710 (Evidence)
Entrez Gene20452 (Evidence)
UniGene306228
DFCITC1584063, TC1614384, TC1680336
DoTSDT.55262642, DT.91336486, DT.97410960
NIA Mouse Gene IndexU021626
EC2.4.99.-
Consensus CDS ProjectCCDS15201.1
International Mouse Knockout Project StatusSt8sia4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040710 Ensembl Gene Model | MGI Sequence Detail 79911 C57BL/6J ±  kb
transcript ENSMUST00000043336 Ensembl | MGI Sequence Detail 5411 Not Applicable 
polypeptide ENSMUSP00000043477 Ensembl | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(681 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001675 Glycosyl transferase, family 29
InterPro IPR012163 Sialyltransferase
Protein Ontology PR:000015698 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
References (Earliest) J:26814 Yoshida Y, et al., Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain. J Biol Chem. 1995 Jun 16;270(24):14628-33
(Latest) J:202712 Rollenhagen M, et al., Polysialic acid on neuropilin-2 is exclusively synthesized by the polysialyltransferase ST8SiaIV and attached to mucin-type o-glycans located between the b2 and c domain. J Biol Chem. 2013 Aug 9;288(32):22880-92
All references(58)
Other
accession IDs
MGD-MRK-33700

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory