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St8sia4 Gene Detail
Summary
  • Symbol
    St8sia4
  • Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
  • Synonyms
    PST, PST-1, Siat8d, ST8SiaIV
  • Feature Type
    protein coding gene
  • IDs
    MGI:106018
    NCBI Gene: 20452
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:95515407-95595296 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 47.76 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2283 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106018
 protein coding gene Chr1:95515407-95595473 (-)
129S1/SvImJ ENSMUSG00200000226
 protein coding gene Chr1:92657196-92735624 (-)
A/J ENSMUSG00195000272
 protein coding gene Chr1:92224988-92304885 (-)
AKR/J ENSMUSG00220000145
 protein coding gene Chr1:92448427-92526893 (-)
BALB/cJ ENSMUSG00180005621
 protein coding gene Chr1:92532773-92612676 (-)
C3H/HeJ ENSMUSG00175005519
 protein coding gene Chr1:92432930-92512815 (-)
C57BL/6NJ ENSMUSG00215000318
 protein coding gene Chr1:92421134-92501051 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014472
 protein coding gene Chr1:88337438-88419991 (-)
CAST/EiJ ENSTCUG00005000083
 protein coding gene Chr1:92179938-92259151 (-)
CBA/J ENSMUSG00210000062
 protein coding gene Chr1:92282954-92362839 (-)
DBA/2J ENSMUSG00185013035
 protein coding gene Chr1:96719561-96797991 (-)
FVB/NJ ENSMUSG00205000734
 protein coding gene Chr1:91647609-91727500 (-)
JF1/MsJ ENSUMUG00000010258
 protein coding gene Chr1:95497424-95577308 (-)
LP/J ENSMUSG00230018492
 protein coding gene Chr1:95983218-96061650 (-)
NOD/ShiLtJ ENSMUSG00190000248
 protein coding gene Chr1:92296959-92375388 (-)
NZO/HlLtJ ENSMUSG00225003573
 protein coding gene Chr1:99895345-99975818 (-)
PWK/PhJ ENSLUMG00010006316
 protein coding gene Chr1:91900984-91981623 (-)
SPRET/EiJ ENSMSPG00010000605
 protein coding gene Chr1:93924816-93998823 (-)
WSB/EiJ ENSIUOG00005000210
 protein coding gene Chr1:91966461-92044931 (-)



Homology
more
  • Human Ortholog
    ST8SIA4, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST8SIA4, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
  • Synonyms
    PST, PST1, SIAT8-D, SIAT8D, ST8SiaIV, ST8SIA-IV
  • Links
    NCBI Gene ID: 7903
    UniProt: Q92187

  • Chr Location
    5q21.1; chr5:100806933-100903285 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    25 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null adult mice exhibit impaired long term potentiation and impaired long term depression in hippocampal CA1 synapses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    89
  • cDNA Data
    42
  • Literature Summary
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040710 Ensembl Gene Model | MGI Sequence Detail 79890 C57BL/6J ±  kb
transcript ENSMUST00000043336 Ensembl | MGI Sequence Detail 5390 Not Applicable  
polypeptide ENSMUSP00000043477 Ensembl | MGI Sequence Detail 359 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 53
    Genomic 5
    cDNA 42
    Primer pair 4
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-33700
References
more
  • Summaries
    All 87
    Developmental Gene Expression 11
    Gene Ontology 8
    Phenotypes 40
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:381822 Niculovic KM, et al., Polysialic acid regulates glomerular microvasculature formation by interaction with VEGF-A188 in mice. Angiogenesis. 2025 May 24;28(3):31
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory