About   Help   FAQ
St8sia4
Gene Detail
Symbol

Name
ID
St8sia4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
MGI:106018
Synonyms
PST, PST-1, Siat8d, ST8SiaIV
Feature Type
protein coding gene
Genetic Map
Chromosome 1
47.76 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:95587682-95667571 bp, - strand
From VEGA annotation of GRCm38

  79890 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4147  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ST8SIA4
Protein SuperFamily: sialyltransferase
Gene Tree: St8sia4

Human
homologs
ST8SIA4, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7903
neXtProt AC: NX_Q92187

Human Synonyms: PST, PST1, SIAT8D, ST8SIA-IV

Human Chr (Location): 5q21; chr5:100806935-100903285 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null adult mice exhibit impaired long term potentiation and impaired long term depression in hippocampal CA1 synapses.
 
Interactions
St8sia4 interacts with 424 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (109)    Tissues (27)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 15
cDNA source data(38)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ST8SIA4 ZFIN st8sia4    NEW 
Molecular
reagents
All nucleic(45) Genomic(4) cDNA(38) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000048753 (Evidence)
Ensembl Gene Model ENSMUSG00000040710 (Evidence)
Entrez Gene 20452 (Evidence)
UniGene 306228
DFCI TC1584063, TC1614384, TC1680336
DoTS DT.55262642, DT.91336486, DT.97410960
NIA Mouse Gene Index U021626
EC 2.4.99.-
Consensus CDS Project CCDS15201.1
International Mouse Phenotyping Consortium Status St8sia4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048753 VEGA Gene Model | MGI Sequence Detail 79890 C57BL/6J ±  kb
transcript OTTMUST00000124766 VEGA | MGI Sequence Detail 5390 Not Applicable 
polypeptide OTTMUSP00000067819 VEGA | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(681 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001675 Glycosyl transferase, family 29
InterPro IPR012163 Sialyltransferase
Protein Ontology PR:000015698 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
References
(Earliest) J:26814 Yoshida Y, et al., Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain. J Biol Chem. 1995 Jun 16;270(24):14628-33
(Latest) J:221354 Werneburg S, et al., Polysialic acid on SynCAM 1 in NG2 cells and on neuropilin-2 in microglia is confined to intracellular pools that are rapidly depleted upon stimulation. Glia. 2015 Jul;63(7):1240-55
All references(60)
Other
accession IDs
MGD-MRK-33700

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory