About   Help   FAQ
Tra2b Gene Detail
Summary
  • Symbol
    Tra2b
  • Name
    transformer 2 beta homolog (Drosophila)
  • Synonyms
    5730405G21Rik, Sfrs10, Silg41, TRA2beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:106016
    NCBI Gene: 20462
  • Gene Overview
    MyGene.info: TRA2B
Location & Maps
more
  • Sequence Map
    Chr16:22244549-22266005 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21457 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 13.18 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TRA2B, transformer 2 beta homolog (Drosophila)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRA2B, transformer 2 beta homolog (Drosophila)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Htra2-beta, PPP1R156, SFRS10, SRFS10, TRA2-BETA, TRAN2B
  • Links
    NCBI Gene ID: 6434
    neXtProt AC: NX_P62995

  • Chr Location
    3q26.2-q27; chr3:185914568-185938136 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced embryo size and early embryonic lethality associated with deficient vasculogenesis and abnormal allantois morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035118 VEGA Gene Model | MGI Sequence Detail 21457 C57BL/6J ±  kb
transcript OTTMUST00000089370 VEGA | MGI Sequence Detail 3403 Not Applicable  
polypeptide OTTMUSP00000048838 VEGA | MGI Sequence Detail 288 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    86 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000014749 transformer-2 protein homolog beta
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
Molecular
Reagents
less
  • All nucleic 22
    cDNA 20
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-33698, MGI:2444319
References
more
  • Summaries
    All 49
    Developmental Gene Expression 9
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:22945 Mixter PF, et al., Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin. J Immunol. 1995 Mar 1;154(5):2063-74
  • Latest
    J:233627 Salinas E, et al., Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication. J Virol. 2016 Feb;90(3):1397-413

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory