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Cox7a2l Gene Detail
Summary
  • Symbol
    Cox7a2l
  • Name
    cytochrome c oxidase subunit 7A2 like
  • Synonyms
    COX7AR, COX7RP, EB1, Scaf1, SIG81, SIG-81
  • Feature Type
    protein coding gene
  • IDs
    MGI:106015
    NCBI Gene: 20463
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:83809346-83821762 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 53.02 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    117 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106015
 protein coding gene Chr17:83809346-83824759 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024073
 protein coding gene Chr17:86582476-86594829 (-)
A/J MGP_AJ_G0024032
 protein coding gene Chr17:83856202-83868604 (-)
AKR/J MGP_AKRJ_G0024001
 protein coding gene Chr17:85216645-85230214 (-)
BALB/cJ MGP_BALBcJ_G0024033
 protein coding gene Chr17:83720910-83733850 (-)
C3H/HeJ MGP_C3HHeJ_G0023798
 protein coding gene Chr17:86062447-86075801 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024478
 protein coding gene Chr17:89693252-89706122 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021917
 protein coding gene Chr17:79075419-79087544 (-)
CAST/EiJ MGP_CASTEiJ_G0023277
 protein coding gene Chr17:86782317-86795311 (-)
CBA/J MGP_CBAJ_G0023772
 protein coding gene Chr17:93378308-93392549 (-)
DBA/2J MGP_DBA2J_G0023900
 protein coding gene Chr17:82330277-82342565 (-)
FVB/NJ MGP_FVBNJ_G0023866
 protein coding gene Chr17:81833308-81845516 (-)
LP/J MGP_LPJ_G0023984
 protein coding gene Chr17:87329739-87344760 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023894
 protein coding gene Chr17:93512864-93526281 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024523
 protein coding gene Chr17:85698546-85710948 (-)
PWK/PhJ MGP_PWKPhJ_G0023022
 protein coding gene Chr17:81895843-81908496 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022833
 protein coding gene Chr17:82485505-82499582 (-)
WSB/EiJ MGP_WSBEiJ_G0023344
 protein coding gene Chr17:86551329-86563529 (-)



Homology
more
  • Human Ortholog
    COX7A2L, cytochrome c oxidase subunit 7A2 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COX7A2L, cytochrome c oxidase subunit 7A2 like
  • Synonyms
    COX7AR, COX7RP, EB1, SCAF1, SCAFI, SIG81
  • Links
    NCBI Gene ID: 9167
    neXtProt AC: NX_O14548
    UniProt: O14548

  • Chr Location
    2p21; chr2:42333546-42425088 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased running capacity, decrease in metabolic rate and mitochondrial oxidative capacity, whitened brown adipose tissue and severe cold sensitivity. Mice homozygous for an allele encoding the short isoform exhibit higher succinate or pyruvate and malate-driven respiration rates
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    201
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20463 NCBI Gene Model | MGI Sequence Detail 12417 C57BL/6J ±  kb
    transcript NM_001159529 RefSeq | MGI Sequence Detail 1169 C57BL/6  
    polypeptide Q61387 UniProt | EBI | MGI Sequence Detail 111 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000005788 cytochrome c oxidase subunit 7A-related protein, mitochondrial
      (term hierarchy)
    • PDB
      7O37, 7O3C, 7O3E
    • InterPro Domains
      IPR039297 Cytochrome c oxidase subunit VII
      IPR003177 Cytochrome c oxidase subunit VIIa, metazoa
      IPR017267 Cytochrome c oxidase subunit VIIa-related, mitochondrial
      IPR036539 Cytochrome c oxidase, subunit VIIa superfamily
    Molecular
    Reagents
    less
    • All nucleic 201
      cDNA 201

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33697
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:22945 Mixter PF, et al., Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin. J Immunol. 1995 Mar 1;154(5):2063-74
    • Latest
      J:332436 Slavi N, et al., CyclinD2-mediated regulation of neurogenic output from the retinal ciliary margin is perturbed in albinism. Neuron. 2023 Jan 4;111(1):49-64.e5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory