About   Help   FAQ
Slc16a1 Gene Detail
Summary
  • Symbol
    Slc16a1
  • Name
    solute carrier family 16 (monocarboxylic acid transporters), member 1
  • Synonyms
    MCT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106013
    NCBI Gene: 20501
  • Gene Overview
    MyGene.info: SLC16A1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:104638668-104658462 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 45.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    89 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106013
protein coding gene Chr3:104638664-104658462 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027707
protein coding gene Chr3:105947643-105969667 (+)
A/J MGP_AJ_G0027667
protein coding gene Chr3:102581056-102600910 (+)
AKR/J MGP_AKRJ_G0027632
protein coding gene Chr3:105101817-105123114 (+)
BALB/cJ MGP_BALBcJ_G0027679
protein coding gene Chr3:102356233-102375862 (+)
C3H/HeJ MGP_C3HHeJ_G0027409
protein coding gene Chr3:105474766-105496258 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028123
protein coding gene Chr3:109913316-109935172 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025463
protein coding gene Chr3:98692312-98711948 (+)
CAST/EiJ MGP_CASTEiJ_G0026865
protein coding gene Chr3:104587160-104609248 (+)
CBA/J MGP_CBAJ_G0027384
protein coding gene Chr3:113646769-113670621 (+)
DBA/2J MGP_DBA2J_G0027526
protein coding gene Chr3:101833429-101853400 (+)
FVB/NJ MGP_FVBNJ_G0027494
protein coding gene Chr3:99755232-99775615 (+)
LP/J MGP_LPJ_G0027633
protein coding gene Chr3:107316460-107337875 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027524
protein coding gene Chr3:119777813-119800531 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028178
protein coding gene Chr3:104662509-104682012 (+)
PWK/PhJ MGP_PWKPhJ_G0026591
protein coding gene Chr3:101612100-101632151 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026412
protein coding gene Chr3:102711404-102730936 (+)
WSB/EiJ MGP_WSBEiJ_G0026945
protein coding gene Chr3:105223279-105245595 (+)



Homology
more
  • Human Ortholog
    SLC16A1, solute carrier family 16 member 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SLC16A1, solute carrier family 16 member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HHF7, MCT, MCT1, MCT1D
  • Links
    NCBI Gene ID: 6566
    neXtProt AC: NX_P53985
    UniProt: P53985

  • Chr Location
    1p13.2; chr1:112911847-112956353 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes are non-viable, while heterozygous animals are resistant to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032902 Ensembl Gene Model | MGI Sequence Detail 19795 C57BL/6J ±  kb
    transcript ENSMUST00000046212 Ensembl | MGI Sequence Detail 4426 Not Applicable  
    polypeptide ENSMUSP00000045216 Ensembl | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 210
      cDNA 208
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33695, MGI:2139849
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:20825 Garcia CK, et al., cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12. Genomics. 1994 Sep 15;23(2):500-3
    • Latest
      J:262475 Carneiro L, et al., AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice. Mol Metab. 2017 Dec;6(12):1625-1633

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory