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Slc16a1
Gene Detail
Symbol

Name
ID
Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
MGI:106013
Synonyms
MCT1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
45.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:104638668-104658462 bp, + strand
From VEGA annotation of GRCm38

  19795 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20662  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SLC16A1
Gene Tree: Slc16a1

Human
homologs
SLC16A1, solute carrier family 16 (monocarboxylate transporter), member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6566
neXtProt AC: NX_P53985

Human Synonyms: HHF7, MCT, MCT1, MCT1D

Human Chr (Location): 1p12; chr1:112911847-112956353 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human SLC16A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(8) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes are non-viable, while heterozygous animals are resistant to diet-induced obesity.
 
Interactions
Slc16a1 interacts with 339 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (12 records)
Data Summary: Results (418)    Tissues (142)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 412
RT-PCR 6
cDNA source data(206)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc16a1 ; ZFIN slc16a1    NEW 
Molecular
reagents
All nucleic(209) cDNA(207) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022475 (Evidence)
Ensembl Gene Model ENSMUSG00000032902 (Evidence)
Entrez Gene 20501 (Evidence)
UniGene 9086
DFCI TC1752040, TC1573497
DoTS DT.97384801, DT.101191685
Consensus CDS Project CCDS17702.1
International Mouse Phenotyping Consortium Status Slc16a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022475 VEGA Gene Model | MGI Sequence Detail 19795 C57BL/6J ±  kb
transcript OTTMUST00000053776 VEGA | MGI Sequence Detail 4426 Not Applicable 
polypeptide OTTMUSP00000025586 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(8)
Polymorphisms
SNPs within 2kb(89 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR004743 Monocarboxylate transporter
Protein Ontology PR:000014944 monocarboxylate transporter 1
References
(Earliest) J:20825 Garcia CK, et al., cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12. Genomics. 1994 Sep 15;23(2):500-3
(Latest) J:219917 Domenech-Estevez E, et al., Distribution of monocarboxylate transporters in the peripheral nervous system suggests putative roles in lactate shuttling and myelination. J Neurosci. 2015 Mar 11;35(10):4151-6
All references(47)
Other
accession IDs
MGD-MRK-33695, MGI:2139849

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory