Slc16a1
Gene Detail

Symbol Name ID

Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 MGI:106013

Synonyms

MCT1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

45.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:104638668-104658462 bp, + strand From VEGA annotation of GRCm38   19795 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20662  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Slc16a1

Human homologs

Human Homolog		SLC16A1, solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
NCBI Gene ID		6566
neXtProt AC		NX_P53985
Human Synonyms		HHF7, MCT, MCT1
Human Chr (Location)		1p12; chr1:113454469-113498975 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SLC16A1

Alleles and phenotypes

All alleles(8) : Gene trapped(8)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cellular response to organic cyclic compound, lactate transmembrane transport, ...
Component	integral to membrane, membrane, ...
Function	organic cyclic compound binding, protein homodimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (422)    Tissues (144)    Images (38)
Theiler Stages: 2, 3, 5, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	412
RT-PCR	10

cDNA source data(203)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(206) cDNA(204) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000022475 (Evidence)
Ensembl Gene Model	ENSMUSG00000032902 (Evidence)
Entrez Gene	20501 (Evidence)
UniGene	9086
DFCI	TC1573497, TC1752040
DoTS	DT.101191685, DT.97384801
Consensus CDS Project	CCDS17702.1
International Mouse Knockout Project Status	Slc16a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022475	VEGA Gene Model | MGI Sequence Detail	19795	C57BL/6J
transcript	OTTMUST00000053776	VEGA | MGI Sequence Detail	4426	Not Applicable
polypeptide	OTTMUSP00000025586	VEGA | MGI Sequence Detail	493	Not Applicable

All sequences(35) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(69 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011701	Major facilitator superfamily
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
InterPro	IPR004743	Monocarboxylate transporter
Protein Ontology	PR:000014944	monocarboxylate transporter 1

References

(Earliest) J:20825 Garcia CK, et al., cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12. Genomics. 1994 Sep 15;23(2):500-3
(Latest) J:171595 Bonnin A, et al., A transient placental source of serotonin for the fetal forebrain. Nature. 2011 Apr 21;472(7343):347-50
All references(42)

Other accession IDs

MGD-MRK-33695, MGI:2139849