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Tagln Gene Detail
Summary
  • Symbol
    Tagln
  • Name
    transgelin
  • Synonyms
    SM22, Sm22a, SM22alpha, SM-22 alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:106012
    NCBI Gene: 21345
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:45840926-45847356 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 25.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106012
 protein coding gene Chr9:45840917-45847356 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034744
 protein coding gene Chr9:44533914-44541909 (-)
A/J MGP_AJ_G0034725
 protein coding gene Chr9:43274475-43280907 (-)
AKR/J MGP_AKRJ_G0034652
 protein coding gene Chr9:44157800-44164087 (-)
BALB/cJ MGP_BALBcJ_G0034716
 protein coding gene Chr9:42998547-43004971 (-)
C3H/HeJ MGP_C3HHeJ_G0034427
 protein coding gene Chr9:44634627-44641896 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035237
 protein coding gene Chr9:45812374-45818808 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032151
 protein coding gene Chr9:42812988-42819372 (-)
CAST/EiJ MGP_CASTEiJ_G0033749
 protein coding gene Chr9:44483958-44490327 (-)
CBA/J MGP_CBAJ_G0034399
 protein coding gene Chr9:47491589-47498013 (-)
DBA/2J MGP_DBA2J_G0034558
 protein coding gene Chr9:43148683-43155099 (-)
FVB/NJ MGP_FVBNJ_G0034499
 protein coding gene Chr9:42415543-42421855 (-)
LP/J MGP_LPJ_G0034639
 protein coding gene Chr9:44851568-44858000 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034543
 protein coding gene Chr9:49267518-49275609 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035258
 protein coding gene Chr9:44072446-44078932 (-)
PWK/PhJ MGP_PWKPhJ_G0033454
 protein coding gene Chr9:43055533-43062846 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033290
 protein coding gene Chr9:44395919-44402310 (-)
WSB/EiJ MGP_WSBEiJ_G0033862
 protein coding gene Chr9:44120401-44126891 (-)



Homology
more
  • Human Ortholog
    TAGLN, transgelin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAGLN, transgelin
  • Synonyms
    SM22, SM22-alpha, SMCC, TAGLN1, TGLN, WS3-10
  • Links
    NCBI Gene ID: 6876
    neXtProt AC: NX_Q01995
    UniProt: Q01995

  • Chr Location
    11q23.3; chr11:117199294-117207465 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 3 alleles in 3 genetic backgrounds
    38 phenotypes from multigenic genotypes
    129 phenotype references
Mice homozygous for targeted mutations in this gene are viable, fertile and phenotypically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1251
  • Tissues
    211
  • cDNA Data
    16
  • Literature Summary
    225
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 21345 NCBI Gene Model | MGI Sequence Detail 6431 C57BL/6J ±  kb
transcript NM_011526 RefSeq | MGI Sequence Detail 1586 ZRU/MplStud  
polypeptide P37804 UniProt | EBI | MGI Sequence Detail 201 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    Genomic 3
    cDNA 17
    Primer pair 10
    Other 5

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33694
References
more
  • Summaries
    All 389
    Developmental Gene Expression 225
    Gene Ontology 5
    Phenotypes 129
  • Earliest
    J:35896 Almendral JM, et al., Expression, cloning and cDNA sequence of a fibroblast serum-regulated gene encoding a putative actin-associated protein (p27). Exp Cell Res. 1989 Apr;181(2):518-30
  • Latest
    J:345642 Stokes G, et al., Rescuing lung development through embryonic inhibition of histone acetylation. Sci Transl Med. 2024 Jan 31;16(732):eadc8930
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory