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St8sia1
Gene Detail
 Symbol
Name
ID
St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
MGI:106011
Synonyms 9330109E03Rik, alpha-2,8-sialyltransferase, GD3S, GD3 synthase, Siat8, Siat8a, ST8Sia I
Feature Type protein coding gene
Genetic Map
Chromosome 6
74.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:142821545-142964452 bp, - strand
From VEGA annotation of GRCm38

  142908 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2282  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: sialyltransferase
Gene Tree: St8sia1

Human
homologs
Human Homolog ST8SIA1, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
NCBI Gene ID 6489
neXtProt AC  NX_Q92185
Human Synonyms  GD3S, SIAT8, SIAT8A, SIAT8-A, ST8SiaI
Human Chr (Location)  12p12.1-p11.2; chr12:22193391-22334714 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted allele are behaviorally normal with no signs of aberrant brain histology or demyelination. Homozygotes for a knock-out allele are behaviorally intact with normal nervous tissue morphology and sensitivity to Fas-mediated apoptosis but show impaired repair of damaged nerves.
 
Interactions
St8sia1 interacts with 493 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cellular response to heat, lipid metabolic process, ...
Component Golgi apparatus, integral component of Golgi membrane, ...
Function alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity, sialyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (220)    Tissues (153)    Images (31)
Theiler Stages: 12, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 123
Northern blot 5
RT-PCR 92
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(14) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022470 (Evidence)
Ensembl Gene ModelENSMUSG00000030283 (Evidence)
Entrez Gene20449 (Evidence)
DFCITC1583140, TC1587079, TC1646422
NIA Mouse Gene IndexU028008
EC2.4.99.8
Consensus CDS ProjectCCDS20689.1
International Mouse Knockout Project StatusSt8sia1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022470 VEGA Gene Model | MGI Sequence Detail 142908 C57BL/6J ±  kb
transcript OTTMUST00000053754 VEGA | MGI Sequence Detail 8991 Not Applicable 
polypeptide OTTMUSP00000025572 VEGA | MGI Sequence Detail 355 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(8) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(1568 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1570)
Protein-related
information
ResourceIDDescription
InterPro IPR001675 Glycosyl transferase, family 29
InterPro IPR012163 Sialyltransferase
Protein Ontology PR:000015695 alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
References (Earliest) J:26814 Yoshida Y, et al., Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain. J Biol Chem. 1995 Jun 16;270(24):14628-33
(Latest) J:207397 Strotmeier J, et al., Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A. FEBS Lett. 2014 Apr 2;588(7):1087-93
All references(67)
Other
accession IDs
MGD-MRK-18769, MGD-MRK-33693, MGI:2444866

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory