St8sia1 MGI Mouse Gene Detail - MGI:106011 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

St8sia1 Gene Detail

Symbol

St8sia1
Name

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Synonyms

9330109E03Rik, alpha-2,8-sialyltransferase, GD3S, GD3 synthase, Siat8, Siat8a, ST8Sia I

Feature Type

protein coding gene
IDs

MGI:106011
NCBI Gene: 20449
Gene Overview

MyGene.info: ST8SIA1

Sequence Map

Chr6:142821545-142964452 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

142908 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 74.78 cM
Mapping Data

3 experiments

Human Ortholog

ST8SIA1, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

Vertebrate Orthologs

9

Human Ortholog

ST8SIA1, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Orthology source: HomoloGene, HGNC
Synonyms

GD3S, SIAT8, SIAT8A, SIAT8-A, ST8SiaI
Links

HGNC:10869

NCBI Gene ID: 6489

neXtProt AC: NX_Q92185

UniProt: Q92185
Chr Location

12p12.1; chr12:22193391-22334714 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2282
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: ST8SIA1
Protein SuperFamily

sialyltransferase
Gene Tree

St8sia1

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotypes from multigenic genotypes
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Gene trapped

7
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available

Homozygotes for a targeted allele are behaviorally normal with no signs of aberrant brain histology or demyelination. Homozygotes for a knock-out allele are behaviorally intact with normal nervous tissue morphology and sensitivity to Fas-mediated apoptosis but show impaired repair of damaged nerves.

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All GO Annotations

12
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

220
Tissues

155
cDNA Data

13
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN st8sia1

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St8sia1 interacts with 492 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

49
RefSeq

16
UniProt

8
CCDS

CCDS20689.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000022470	VEGA Gene Model \| MGI Sequence Detail	142908	C57BL/6J	± kb
transcript	OTTMUST00000053754	VEGA \| MGI Sequence Detail	8991	Not Applicable
polypeptide	OTTMUSP00000025572	VEGA \| MGI Sequence Detail	355	Not Applicable

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SNPs within 2kb

1580 from dbSNP Build 142

RFLP

1

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UniProt

8 Sequences
Protein Ontology

PR:000015695 alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

(term hierarchy)
EC

2.4.99.8
InterPro Domains

IPR001675 Glycosyl transferase family 29

IPR012163 Sialyltransferase

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All nucleic 18

cDNA 14

Primer pair 4

Microarray probesets 4

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MGD-MRK-18769, MGD-MRK-33693, MGI:2444866

Summaries

All 67

Developmental Gene Expression 11

Gene Ontology 5

Phenotypes 29
Earliest

J:26814 Yoshida Y, et al., Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain. J Biol Chem. 1995 Jun 16;270(24):14628-33
Latest

J:239128 Ji S, et al., Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice. Biochem Biophys Res Commun. 2016 Oct 21;479(3):453-460

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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