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St8sia1 Gene Detail
Summary
  • Symbol
    St8sia1
  • Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
  • Synonyms
    9330109E03Rik, alpha-2,8-sialyltransferase, GD3S, GD3 synthase, Siat8, Siat8a, ST8Sia I
  • Feature Type
    protein coding gene
  • IDs
    MGI:106011
    NCBI Gene: 20449
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:142767271-142910178 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 74.78 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4469 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106011
 protein coding gene Chr6:142767267-142935247 (-)
129S1/SvImJ ENSMUSG00200031945
 protein coding gene Chr6:140308543-140451480 (-)
A/J ENSMUSG00195007947
 protein coding gene Chr6:139214983-139357940 (-)
AKR/J ENSMUSG00220027346
 protein coding gene Chr6:137441878-137584831 (-)
BALB/cJ ENSMUSG00180015602
 protein coding gene Chr6:139342482-139485414 (-)
C3H/HeJ ENSMUSG00175033560
 protein coding gene Chr6:139241799-139384737 (-)
C57BL/6NJ ENSMUSG00215021606
 protein coding gene Chr6:139413796-139556727 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029039
 protein coding gene Chr6:140658964-140796599 (-)
CAST/EiJ ENSTCUG00005036211
 protein coding gene Chr6:140076706-140215319 (-)
CBA/J ENSMUSG00210003636
 protein coding gene Chr6:139304489-139447411 (-)
DBA/2J ENSMUSG00185021970
 protein coding gene Chr6:139955017-140097968 (-)
FVB/NJ ENSMUSG00205020930
 protein coding gene Chr6:138324187-138465822 (-)
JF1/MsJ ENSUMUG00000005208
 protein coding gene Chr6:138615395-138758353 (-)
LP/J ENSMUSG00230007102
 protein coding gene Chr6:141089973-141236256 (-)
NOD/ShiLtJ ENSMUSG00190006499
 protein coding gene Chr6:139775884-139917983 (-)
NZO/HlLtJ ENSMUSG00225013452
 protein coding gene Chr6:143945025-144087939 (-)
PWK/PhJ ENSLUMG00010029809
 protein coding gene Chr6:137694948-137832706 (-)
SPRET/EiJ ENSMSPG00010016242
 protein coding gene Chr6:141621027-141753093 (-)
WSB/EiJ ENSIUOG00005020810
 protein coding gene Chr6:140019640-140159192 (-)



Homology
more
  • Human Ortholog
    ST8SIA1, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST8SIA1, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
  • Synonyms
    GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI
  • Links
    NCBI Gene ID: 6489
    UniProt: Q92185

  • Chr Location
    12p12.1; chr12:22063773-22437041 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted allele are behaviorally normal with no signs of aberrant brain histology or demyelination. Homozygotes for a knock-out allele are behaviorally intact with normal nervous tissue morphology and sensitivity to Fas-mediated apoptosis but show impaired repair of damaged nerves.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    817
  • Tissues
    155
  • cDNA Data
    14
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030283 Ensembl Gene Model | MGI Sequence Detail 142908 C57BL/6J ±  kb
    transcript ENSMUST00000032421 Ensembl | MGI Sequence Detail 8991 Not Applicable  
    polypeptide ENSMUSP00000032421 Ensembl | MGI Sequence Detail 355 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 15
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18769, MGD-MRK-33693, MGI:2444866
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 12
      Gene Ontology 14
      Phenotypes 51
    • Earliest
      J:26814 Yoshida Y, et al., Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain. J Biol Chem. 1995 Jun 16;270(24):14628-33
    • Latest
      J:386381 Puljko B, et al., GD3 synthase deficiency disrupts Na(+)/K(+)-ATPase and plasma membrane Ca(2+)-ATPase function in mouse brain. Neurobiol Dis. 2026 May 15;:107453
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory