St8sia1
Gene Detail

Symbol

Name
ID

St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
MGI:106011

Synonyms

9330109E03Rik, alpha-2,8-sialyltransferase, GD3S, GD3 synthase, Siat8, Siat8a, ST8Sia I

Feature Type

protein coding gene

Genetic Map

Chromosome 6
74.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:142821545-142964452 bp, - strand From VEGA annotation of GRCm38   142908 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:2282  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: sialyltransferase
Gene Tree: St8sia1

Human
homologs

Human Homolog		ST8SIA1, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
NCBI Gene ID		6489
neXtProt AC		NX_Q92185
Human Synonyms		GD3S, SIAT8, SIAT8A, SIAT8-A, ST8SiaI
Human Chr (Location)		12p12.1-p11.2; chr12:22193391-22334714 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for a targeted allele are behaviorally normal with no signs of aberrant brain histology or demyelination. Homozygotes for a knock-out allele are behaviorally intact with normal nervous tissue morphology and sensitivity to Fas-mediated apoptosis but show impaired repair of damaged nerves.

 

Interactions

St8sia1 interacts with 493 markers (Mir1b, Mir7-1, Mir7-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (14 annotations)

Process	cellular response to heat, lipid metabolic process, ...
Component	Golgi apparatus, integral component of Golgi membrane, ...
Function	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity, sialyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)

Data Summary: Results (220)    Tissues (155)    Images (31)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	123
Northern blot	5
RT-PCR	92

cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(18) cDNA(14) Primer pair(4)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000022470 (Evidence)
Ensembl Gene Model	ENSMUSG00000030283 (Evidence)
Entrez Gene	20449 (Evidence)
DFCI	TC1646422, TC1587079, TC1583140
NIA Mouse Gene Index	U028008
EC	2.4.99.8
Consensus CDS Project	CCDS20689.1
International Mouse Knockout Project Status	St8sia1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022470	VEGA Gene Model | MGI Sequence Detail	142908	C57BL/6J
transcript	OTTMUST00000053754	VEGA | MGI Sequence Detail	8991	Not Applicable
polypeptide	OTTMUSP00000025572	VEGA | MGI Sequence Detail	355	Not Applicable

All sequences(46) RefSeq(14) UniProt(7)

Polymorphisms

RFLP(1) : SNPs within 2kb(1568 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1570)

Protein-related
information

Resource	ID	Description
InterPro	IPR001675	Glycosyl transferase, family 29
InterPro	IPR012163	Sialyltransferase
Protein Ontology	PR:000015695	alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

References

(Earliest) J:26814 Yoshida Y, et al., Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain. J Biol Chem. 1995 Jun 16;270(24):14628-33
(Latest) J:217179 Wang J, et al., Ganglioside GD3 is required for neurogenesis and long-term maintenance of neural stem cells in the postnatal mouse brain. J Neurosci. 2014 Oct 8;34(41):13790-800
All references(70)

Other
accession IDs

MGD-MRK-18769, MGD-MRK-33693, MGI:2444866