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St8sia1
Gene Detail
Symbol

Name
ID
St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
MGI:106011
Synonyms
9330109E03Rik, alpha-2,8-sialyltransferase, GD3S, GD3 synthase, Siat8, Siat8a, ST8Sia I
Feature Type
protein coding gene
Genetic Map
Chromosome 6
74.78 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:142821545-142964452 bp, - strand
From VEGA annotation of GRCm38

  142908 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2282  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: ST8SIA1
Protein SuperFamily: sialyltransferase
Gene Tree: St8sia1

Human
homologs
ST8SIA1, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6489
neXtProt AC: NX_Q92185

Human Synonyms: GD3S, SIAT8, SIAT8A, SIAT8-A, ST8SiaI

Human Chr (Location): 12p12.1-p11.2; chr12:22129135-22334714 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted allele are behaviorally normal with no signs of aberrant brain histology or demyelination. Homozygotes for a knock-out allele are behaviorally intact with normal nervous tissue morphology and sensitivity to Fas-mediated apoptosis but show impaired repair of damaged nerves.
 
Interactions
St8sia1 interacts with 492 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (220)    Tissues (155)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 123
Northern blot 5
RT-PCR 92
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase st8sia1 ; ZFIN st8sia1    NEW 
Molecular
reagents
All nucleic(18) cDNA(14) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022470 (Evidence)
Ensembl Gene Model ENSMUSG00000030283 (Evidence)
Entrez Gene 20449 (Evidence)
DFCI TC1583140, TC1587079, TC1646422
NIA Mouse Gene Index U028008
EC 2.4.99.8
Consensus CDS Project CCDS20689.1
International Mouse Phenotyping Consortium Status St8sia1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022470 VEGA Gene Model | MGI Sequence Detail 142908 C57BL/6J ±  kb
transcript OTTMUST00000053754 VEGA | MGI Sequence Detail 8991 Not Applicable 
polypeptide OTTMUSP00000025572 VEGA | MGI Sequence Detail 355 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(14) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(1568 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1570)
Protein-related
information
ResourceIDDescription
InterPro IPR001675 Glycosyl transferase, family 29
InterPro IPR012163 Sialyltransferase
Protein Ontology PR:000015695 alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
References
(Earliest) J:26814 Yoshida Y, et al., Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain. J Biol Chem. 1995 Jun 16;270(24):14628-33
(Latest) J:217179 Wang J, et al., Ganglioside GD3 is required for neurogenesis and long-term maintenance of neural stem cells in the postnatal mouse brain. J Neurosci. 2014 Oct 8;34(41):13790-800
All references(68)
Other
accession IDs
MGD-MRK-18769, MGD-MRK-33693, MGI:2444866

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory