About   Help   FAQ
St8sia1 Gene Detail
Summary
  • Symbol
    St8sia1
  • Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
  • Synonyms
    9330109E03Rik, alpha-2,8-sialyltransferase, GD3S, GD3 synthase, Siat8, Siat8a, ST8Sia I
  • Feature Type
    protein coding gene
  • IDs
    MGI:106011
    NCBI Gene: 20449
  • Gene Overview
    MyGene.info: ST8SIA1
Location & Maps
more
  • Sequence Map
    Chr6:142821545-142964452 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      142908 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 74.78 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ST8SIA1, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ST8SIA1, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GD3S, SIAT8, SIAT8A, SIAT8-A, ST8SiaI
  • Links
    NCBI Gene ID: 6489
    neXtProt AC: NX_Q92185
    UniProt: Q92185

  • Chr Location
    12p12.1; chr12:22193391-22334714 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted allele are behaviorally normal with no signs of aberrant brain histology or demyelination. Homozygotes for a knock-out allele are behaviorally intact with normal nervous tissue morphology and sensitivity to Fas-mediated apoptosis but show impaired repair of damaged nerves.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    220
  • Tissues
    155
  • cDNA Data
    13
  • Literature Summary
    11
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022470 VEGA Gene Model | MGI Sequence Detail 142908 C57BL/6J ±  kb
transcript OTTMUST00000053754 VEGA | MGI Sequence Detail 8991 Not Applicable  
polypeptide OTTMUSP00000025572 VEGA | MGI Sequence Detail 355 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1580 from dbSNP Build 142
  • RFLP
    1
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 14
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-18769, MGD-MRK-33693, MGI:2444866
References
more
  • Summaries
    All 67
    Developmental Gene Expression 11
    Gene Ontology 5
    Phenotypes 29
  • Earliest
    J:26814 Yoshida Y, et al., Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain. J Biol Chem. 1995 Jun 16;270(24):14628-33
  • Latest
    J:239128 Ji S, et al., Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice. Biochem Biophys Res Commun. 2016 Oct 21;479(3):453-460
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
05/16/2017
MGI 6.09 		The Jackson Laboratory