Anxa5
Gene Detail

Symbol Name ID

Anxa5 annexin A5 MGI:106008

Synonyms

annexin V, Anx5

Feature Type

protein coding gene

Genetic Map

Chromosome 3

17.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr3:36448925-36475843 bp, - strand From VEGA annotation of GRCm38   26919 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20312  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Anxa5

Human homologs

Human Homolog		ANXA5, annexin A5
NCBI Gene ID		308
neXtProt AC		NX_P08758
Human Synonyms		ANX5, ENX2, PP4, RPRGL3
Human Chr (Location)		4q27; chr4:122589152-122618147 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ANXA5

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Homozygous null mice are viable, fertile, and develop normally. Bone development and maintenance are normal, as are clinical-chemical parameters.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	blood coagulation, hemostasis, ...
Component	cell projection, cytoplasm, ...
Function	calcium-dependent phospholipid binding, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (338)    Tissues (104)    Images (59)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 23, 25, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	258
In situ reporter (knock in)	22
RT-PCR	54

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(5) cDNA(13) Primer pair(5)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000020273 (Evidence)
Ensembl Gene Model	ENSMUSG00000027712 (Evidence)
Entrez Gene	11747 (Evidence)
DFCI	TC1573579, TC1590963, TC1703947
DoTS	DT.495192
NIA Mouse Gene Index	U023945
Consensus CDS Project	CCDS38416.1
International Mouse Knockout Project Status	Anxa5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020273	VEGA Gene Model | MGI Sequence Detail	26919	C57BL/6J
transcript	OTTMUST00000048111	VEGA | MGI Sequence Detail	1678	Not Applicable
polypeptide	OTTMUSP00000021966	VEGA | MGI Sequence Detail	319	Not Applicable

All sequences(28) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(144 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001464	Annexin
InterPro	IPR018502	Annexin repeat
InterPro	IPR018252	Annexin repeat, conserved site
InterPro	IPR002392	Annexin, type V
InterPro	IPR015473	Annexin V
Protein Ontology	PR:000004078	annexin A5

References

(Earliest) J:35723 Chepenik KP, et al., Developmental regulation of various annexins in the embryonic palate of the mouse: dexamethasone affects expression of annexin-1. J Craniofac Genet Dev Biol. 1995 Oct-Dec;15(4):171-81
(Latest) J:195228 Leikina E, et al., Extracellular annexins and dynamin are important for sequential steps in myoblast fusion. J Cell Biol. 2013 Jan 7;200(1):109-23
All references(70)

Other accession IDs

MGD-MRK-33688, MGI:2140106