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Anxa5 Gene Detail
Summary
  • Symbol
    Anxa5
  • Name
    annexin A5
  • Synonyms
    annexin V, Anx5
  • Feature Type
    protein coding gene
  • IDs
    MGI:106008
    NCBI Gene: 11747
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:36503072-36530036 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 17.46 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    240 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106008
protein coding gene Chr3:36503072-36530043 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027158
protein coding gene Chr3:34243027-34272508 (-)
A/J MGP_AJ_G0027118
protein coding gene Chr3:33594407-33621182 (-)
AKR/J MGP_AKRJ_G0027087
protein coding gene Chr3:34209181-34240782 (-)
BALB/cJ MGP_BALBcJ_G0027130
protein coding gene Chr3:33352549-33381057 (-)
C3H/HeJ MGP_C3HHeJ_G0026873
protein coding gene Chr3:34274707-34301277 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027576
protein coding gene Chr3:35895114-35922728 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024937
protein coding gene Chr3:31291460-31320385 (-)
CAST/EiJ MGP_CASTEiJ_G0026326
protein coding gene Chr3:34121686-34150557 (-)
CBA/J MGP_CBAJ_G0026850
protein coding gene Chr3:36863643-36894896 (-)
DBA/2J MGP_DBA2J_G0026984
protein coding gene Chr3:33048644-33075979 (-)
FVB/NJ MGP_FVBNJ_G0026952
protein coding gene Chr3:32506911-32533689 (-)
LP/J MGP_LPJ_G0027096
protein coding gene Chr3:35022119-35053875 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026972
protein coding gene Chr3:39285838-39315961 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027635
protein coding gene Chr3:34053747-34080276 (-)
PWK/PhJ MGP_PWKPhJ_G0026059
protein coding gene Chr3:32696860-32724766 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025871
protein coding gene Chr3:33432834-33461624 (-)
WSB/EiJ MGP_WSBEiJ_G0026400
protein coding gene Chr3:34076566-34104731 (-)



Homology
more
  • Human Ortholog
    ANXA5, annexin A5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANXA5, annexin A5
  • Synonyms
    ANX5, CPB-I, ENX2, HEL-S-7, PP4, RPRGL3, VAC-alph
  • Links
    NCBI Gene ID: 308
    neXtProt AC: NX_P08758
    UniProt: P08758

  • Chr Location
    4q27; chr4:121667946-121696995 (-)  GRCh38

Human Diseases
more
  • Diseases
    3 with human ANXA5 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable, fertile, and develop normally. Bone development and maintenance are normal, as are clinical-chemical parameters.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11747 NCBI Gene Model | MGI Sequence Detail 26965 C57BL/6J ±  kb
transcript NM_009673 RefSeq | MGI Sequence Detail 1738 ZRU/MplStud  
polypeptide P48036 UniProt | EBI | MGI Sequence Detail 319 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 195
    Genomic 5
    cDNA 183
    Primer pair 7

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33688, MGI:2140106
References
more
  • Summaries
    All 96
    Developmental Gene Expression 26
    Diseases 1
    Gene Ontology 16
    Phenotypes 20
  • Earliest
    J:35723 Chepenik KP, et al., Developmental regulation of various annexins in the embryonic palate of the mouse: dexamethasone affects expression of annexin-1. J Craniofac Genet Dev Biol. 1995 Oct-Dec;15(4):171-81
  • Latest
    J:333323 Chen H, et al., PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371. Blood. 2023 Jan 19;141(3):244-259

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory