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Anxa5 Gene Detail
Summary
  • Symbol
    Anxa5
  • Name
    annexin A5
  • Synonyms
    annexin V, Anx5
  • Feature Type
    protein coding gene
  • IDs
    MGI:106008
    NCBI Gene: 11747
  • Gene Overview
    MyGene.info: ANXA5
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:36448923-36475887 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 17.46 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    240 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106008
protein coding gene Chr3:36448923-36475894 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027158
protein coding gene Chr3:34243027-34272508 (-)
A/J MGP_AJ_G0027118
protein coding gene Chr3:33594407-33621182 (-)
AKR/J MGP_AKRJ_G0027087
protein coding gene Chr3:34209181-34240782 (-)
BALB/cJ MGP_BALBcJ_G0027130
protein coding gene Chr3:33352549-33381057 (-)
C3H/HeJ MGP_C3HHeJ_G0026873
protein coding gene Chr3:34274707-34301277 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027576
protein coding gene Chr3:35895114-35922728 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024937
protein coding gene Chr3:31291460-31320385 (-)
CAST/EiJ MGP_CASTEiJ_G0026326
protein coding gene Chr3:34121686-34150557 (-)
CBA/J MGP_CBAJ_G0026850
protein coding gene Chr3:36863643-36894896 (-)
DBA/2J MGP_DBA2J_G0026984
protein coding gene Chr3:33048644-33075979 (-)
FVB/NJ MGP_FVBNJ_G0026952
protein coding gene Chr3:32506911-32533689 (-)
LP/J MGP_LPJ_G0027096
protein coding gene Chr3:35022119-35053875 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026972
protein coding gene Chr3:39285838-39315961 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027635
protein coding gene Chr3:34053747-34080276 (-)
PWK/PhJ MGP_PWKPhJ_G0026059
protein coding gene Chr3:32696860-32724766 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025871
protein coding gene Chr3:33432834-33461624 (-)
WSB/EiJ MGP_WSBEiJ_G0026400
protein coding gene Chr3:34076566-34104731 (-)



Homology
more
  • Human Ortholog
    ANXA5, annexin A5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANXA5, annexin A5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ANX5, ENX2, HEL-S-7, PP4, RPRGL3
  • Links
    NCBI Gene ID: 308
    neXtProt AC: NX_P08758
    UniProt: P08758

  • Chr Location
    4q27; chr4:121667997-121696992 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20312
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ANXA5
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are viable, fertile, and develop normally. Bone development and maintenance are normal, as are clinical-chemical parameters.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11747 NCBI Gene Model | MGI Sequence Detail 26965 C57BL/6J ±  kb
transcript NM_009673 RefSeq | MGI Sequence Detail 1738 C57BL/6  
polypeptide P48036 UniProt | EBI | MGI Sequence Detail 319 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 193
    Genomic 5
    cDNA 183
    Primer pair 5

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33688, MGI:2140106
References
more
  • Summaries
    All 82
    Developmental Gene Expression 21
    Diseases 1
    Gene Ontology 16
    Phenotypes 14
  • Earliest
    J:35723 Chepenik KP, et al., Developmental regulation of various annexins in the embryonic palate of the mouse: dexamethasone affects expression of annexin-1. J Craniofac Genet Dev Biol. 1995 Oct-Dec;15(4):171-81
  • Latest
    J:256070 Verma SK, et al., Cell-surface phosphatidylserine regulates osteoclast precursor fusion. J Biol Chem. 2018 Jan 5;293(1):254-270

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory