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Anxa5
Gene Detail
Symbol

Name
ID
Anxa5
annexin A5
MGI:106008
Synonyms
annexin V, Anx5
Feature Type
protein coding gene
Genetic Map
Chromosome 3
17.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr3:36448925-36475843 bp, - strand
From VEGA annotation of GRCm38

  26919 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20312  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Anxa5

Human
homologs
Human Homolog ANXA5, annexin A5
NCBI Gene ID 308
neXtProt AC  NX_P08758
Human Synonyms  ANX5, ENX2, HEL-S-7, PP4, RPRGL3
Human Chr (Location)  4q27; chr4:121667997-121696992 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ANXA5
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable, fertile, and develop normally. Bone development and maintenance are normal, as are clinical-chemical parameters.
 
Interactions
Anxa5 interacts with 86 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process blood coagulation, hemostasis, ...
Component cell projection, cytoplasm, ...
Function calcium-dependent phospholipid binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (338)    Tissues (104)    Images (59)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 258
In situ reporter (knock in) 22
RT-PCR 54
cDNA source data(181)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(192) Genomic(5) cDNA(182) Primer pair(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020273 (Evidence)
Ensembl Gene ModelENSMUSG00000027712 (Evidence)
Entrez Gene11747 (Evidence)
UniGene1620
DFCITC1590963, TC1573579, TC1703947
DoTSDT.495192
NIA Mouse Gene IndexU023945
Consensus CDS ProjectCCDS38416.1
International Mouse Knockout Project StatusAnxa5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020273 VEGA Gene Model | MGI Sequence Detail 26919 C57BL/6J ±  kb
transcript OTTMUST00000048111 VEGA | MGI Sequence Detail 1678 Not Applicable 
polypeptide OTTMUSP00000021966 VEGA | MGI Sequence Detail 319 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(241 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001464 Annexin
InterPro IPR018502 Annexin repeat
InterPro IPR018252 Annexin repeat, conserved site
InterPro IPR002392 Annexin, type V
InterPro IPR015473 Annexin V
Protein Ontology PR:000004078 annexin A5
References
(Earliest) J:35723 Chepenik KP, et al., Developmental regulation of various annexins in the embryonic palate of the mouse: dexamethasone affects expression of annexin-1. J Craniofac Genet Dev Biol. 1995 Oct-Dec;15(4):171-81
(Latest) J:211449 Tritsch E, et al., An SRF/miR-1 axis regulates NCX1 and annexin A5 protein levels in the normal and failing heart. Cardiovasc Res. 2013 Jun 1;98(3):372-80
All references(76)
Other
accession IDs
MGD-MRK-33688, MGI:2140106

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory