Tkt MGI Mouse Gene Detail - MGI:105992

Symbol

Tkt
Name

transketolase
Synonyms

p68

Feature Type

protein coding gene
IDs

MGI:105992
NCBI Gene: 21881
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr14:30271088-30296681 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 18.79 cM, cytoband B1
Mapping Data

3 experiments

SNPs within 2kb

1316 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105992	protein coding gene	Chr14:30270316-30296681 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021104	protein coding gene	Chr14:23673956-23699090 (+)
A/J	MGP_AJ_G0021052	protein coding gene	Chr14:22795766-22821840 (+)
AKR/J	MGP_AKRJ_G0021029	protein coding gene	Chr14:23903059-23929110 (+)
BALB/cJ	MGP_BALBcJ_G0021056	protein coding gene	Chr14:22890314-22916633 (+)
C3H/HeJ	MGP_C3HHeJ_G0020839	protein coding gene	Chr14:23757502-23784477 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021488	protein coding gene	Chr14:24618819-24644576 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019051	protein coding gene	Chr14:22859858-22885935 (+)
CAST/EiJ	MGP_CASTEiJ_G0020364	protein coding gene	Chr14:23500030-23529017 (+)
CBA/J	MGP_CBAJ_G0020806	protein coding gene	Chr14:25565710-25595094 (+)
DBA/2J	MGP_DBA2J_G0020928	protein coding gene	Chr14:22828291-22854294 (+)
FVB/NJ	MGP_FVBNJ_G0020912	protein coding gene	Chr14:22784705-22811618 (+)
LP/J	MGP_LPJ_G0020997	protein coding gene	Chr14:23998011-24024438 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020938	protein coding gene	Chr14:24856153-24883476 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021521	protein coding gene	Chr14:23651532-23677638 (+)
PWK/PhJ	MGP_PWKPhJ_G0020112	protein coding gene	Chr14:22266096-22292176 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019936	protein coding gene	Chr14:23244949-23269873 (+)
WSB/EiJ	MGP_WSBEiJ_G0020419	protein coding gene	Chr14:23711775-23740299 (+)

Human Ortholog

TKT, transketolase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TKT, transketolase
Synonyms

HEL107, HEL-S-48, SDDHD, TK, TKT1
Links

HGNC:11834

NCBI Gene ID: 7086

UniProt: P29401
Chr Location

3p21.1; chr3:53224712-53256052 (-) GRCh38

MGI Vertebrate Homology

Tkt stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TKT
Gene Tree

Tkt

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

39
Endonuclease-mediated

5
Gene trapped

30
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation die at or before the morula stage. Heterozygotes show reduced growth, decreased fat accumulation, microphthalmia, and reduced female fertility.

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All GO Annotations

45
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

901
Tissues

156
cDNA Data

494
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TKT

Xenbase tkt

ZFIN tktb

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All Sequences

88
RefSeq

3
UniProt

3
CCDS

CCDS26894.1

Ensembl

ENSMUSG00000021957 (Evidence)
NCBI Gene

21881

			Length	Strain/Species	Flank
genomic	21881	NCBI Gene Model \| MGI Sequence Detail	25594	C57BL/6J	± kb
transcript	NM_009388	RefSeq \| MGI Sequence Detail	3242	C57BL/6
polypeptide	P40142	UniProt \| EBI \| MGI Sequence Detail	623	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016369 transketolase

(term hierarchy)
EC

2.2.1.1
InterPro Domains

IPR029061 Thiamin diphosphate-binding fold

IPR020826 Transketolase binding site

IPR049557 Transketolase conserved site

IPR033248 Transketolase, C-terminal domain

IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II

IPR051424 Transketolase-like

IPR005475 Transketolase-like, pyrimidine-binding domain

IPR005474 Transketolase, N-terminal
GlyGen

P40142 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 499

Genomic 1

cDNA 494

Primer pair 4

Microarray probesets 5

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MGD-MRK-33672

Summaries

All 65

Developmental Gene Expression 9

Gene Ontology 13

Phenotypes 16
Earliest

J:322975 HIATT HH, Glycogen formation via the pentose phosphate pathway in mice in vivo. J Biol Chem. 1957 Feb;224(2):851-9
Latest

J:352498 Liu MJ, et al., HMGA1 promotes the progression of esophageal squamous cell carcinoma by elevating TKT-mediated upregulation of pentose phosphate pathway. Cell Death Dis. 2024 Jul 30;15(7):541

TSS for Tkt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124827	Chr14:30271096-30271116 (+)	18 bp
Tssr124828	Chr14:30271120-30271145 (+)	45 bp
Tssr124829	Chr14:30280668-30280685 (+)	9,589 bp
Tssr124830	Chr14:30280744-30280762 (+)	9,665 bp
Tssr124831	Chr14:30281737-30281756 (+)	10,659 bp
Tssr124832	Chr14:30287466-30287518 (+)	16,404 bp
Tssr124833	Chr14:30287563-30287592 (+)	16,490 bp
Tssr124834	Chr14:30290133-30290166 (+)	19,062 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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