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Tkt Gene Detail
Summary
  • Symbol
    Tkt
  • Name
    transketolase
  • Synonyms
    p68
  • Feature Type
    protein coding gene
  • IDs
    MGI:105992
    NCBI Gene: 21881
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr14:30548359-30574722 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      26364 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 18.79 cM, cytoband B1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TKT, transketolase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TKT, transketolase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL107, HEL-S-48, SDDHD, TK, TKT1
  • Links
    NCBI Gene ID: 7086
    neXtProt AC: NX_P29401
    UniProt: P29401

  • Chr Location
    3p21.1; chr3:53224707-53256114 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation die at or before the morula stage. Heterozygotes show reduced growth, decreased fat accumulation, microphthalmia, and reduced female fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    181
  • Tissues
    152
  • cDNA Data
    493
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000035018 VEGA Gene Model | MGI Sequence Detail 26364 C57BL/6J ±  kb
    transcript OTTMUST00000089041 VEGA | MGI Sequence Detail 3225 Not Applicable  
    polypeptide OTTMUSP00000048606 VEGA | MGI Sequence Detail 623 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      243 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 496
      Genomic 1
      cDNA 493
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33672
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:31736 Schimmer BP, et al., Amplification of the transketolase gene in desensitization-resistant mutant Y1 mouse adrenocortical tumor cells. J Biol Chem. 1996 Mar 1;271(9):4993-8
    • Latest
      J:251107 Kim H, et al., Identification of transketolase as a target of PARIS in substantia nigra. Biochem Biophys Res Commun. 2017 Nov 18;493(2):1050-1056
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/08/2018
    MGI 6.12     		The Jackson Laboratory