About   Help   FAQ
Tkt
Gene Detail
 Symbol
Name
ID
Tkt
transketolase
MGI:105992
Synonyms p68
Feature Type protein coding gene
Genetic Map
Chromosome 14
18.79 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:30548359-30574722 bp, + strand
From VEGA annotation of GRCm38

  26364 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68154  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transketolase
Gene Tree: Tkt

Human
homologs
Human Homolog TKT, transketolase
NCBI Gene ID 7086
neXtProt AC  NX_P29401
Human Synonyms  HEL107, TK, TKT1
Human Chr (Location)  3p14.3; chr3:53224707-53256114 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(32) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation die at or before the morula stage. Heterozygotes show reduced growth, decreased fat accumulation, microphthalmia, and reduced female fertility.
 
Interactions
Tkt interacts with 188 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process glyceraldehyde-3-phosphate biosynthetic process, metabolic process, ...
Component endoplasmic reticulum membrane, extracellular vesicular exosome, ...
Function carbohydrate binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (181)    Tissues (148)    Images (29)
Theiler Stages: 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 109
Northern blot 20
Western blot 6
RT-PCR 46
cDNA source data(493)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(496) Genomic(1) cDNA(493) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000035018 (Evidence)
Ensembl Gene ModelENSMUSG00000021957 (Evidence)
Entrez Gene21881 (Evidence)
UniGene290692
DFCITC1573822, TC1620951
DoTSDT.101404947, DT.101404949, DT.536649, DT.94124924
NIA Mouse Gene IndexU015442
EC2.2.1.1
Consensus CDS ProjectCCDS26894.1
International Mouse Knockout Project StatusTkt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035018 VEGA Gene Model | MGI Sequence Detail 26364 C57BL/6J ±  kb
transcript OTTMUST00000089041 VEGA | MGI Sequence Detail 3225 Not Applicable 
polypeptide OTTMUSP00000048606 VEGA | MGI Sequence Detail 623 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(3) UniProt(2)
Polymorphisms SNPs within 2kb(244 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020826 Transketolase binding site
InterPro IPR005476 Transketolase, C-terminal
InterPro IPR009014 Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II
InterPro IPR005475 Transketolase-like, pyrimidine-binding domain
InterPro IPR005474 Transketolase, N-terminal
Protein Ontology PR:000016369 transketolase
References (Earliest) J:31736 Schimmer BP, et al., Amplification of the transketolase gene in desensitization-resistant mutant Y1 mouse adrenocortical tumor cells. J Biol Chem. 1996 Mar 1;271(9):4993-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(47)
Other
accession IDs
MGD-MRK-33672

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory