Tkt MGI Mouse Gene Detail - MGI:105992

Tkt Gene Detail

Symbol

Tkt
Name

transketolase
Synonyms

p68

Feature Type

protein coding gene
IDs

MGI:105992
NCBI Gene: 21881

Sequence Map

Chr14:30548359-30574722 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

26364 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 18.79 cM, cytoband B1
Mapping Data

3 experiments

Human Ortholog

TKT, transketolase

Vertebrate Orthologs

9

Human Ortholog

TKT, transketolase
Orthology source: HomoloGene, HGNC
Synonyms

HEL107, HEL-S-48, SDDHD, TK, TKT1
Links

HGNC:11834

NCBI Gene ID: 7086

neXtProt AC: NX_P29401

UniProt: P29401
Chr Location

3p21.1; chr3:53224707-53256114 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 68154
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: TKT
Protein SuperFamily

transketolase
Gene Tree

Tkt

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Gene trapped

32
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available

Homozygotes for a targeted null mutation die at or before the morula stage. Heterozygotes show reduced growth, decreased fat accumulation, microphthalmia, and reduced female fertility.

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All GO Annotations

27
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

181
Tissues

152
cDNA Data

493
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TKT

Xenbase tkt

ZFIN tktb

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Tkt interacts with 188 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

72
RefSeq

3
UniProt

2
CCDS

CCDS26894.1
UniGene

290692

			Length	Strain/Species	Flank
genomic	OTTMUSG00000035018	VEGA Gene Model \| MGI Sequence Detail	26364	C57BL/6J	± kb
transcript	OTTMUST00000089041	VEGA \| MGI Sequence Detail	3225	Not Applicable
polypeptide	OTTMUSP00000048606	VEGA \| MGI Sequence Detail	623	Not Applicable

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SNPs within 2kb

243 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000016369 transketolase

(term hierarchy)
EC

2.2.1.1
InterPro Domains

IPR029061 Thiamin diphosphate-binding fold

IPR020826 Transketolase binding site

IPR033248 Transketolase, C-terminal domain

IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II

IPR005475 Transketolase-like, pyrimidine-binding domain

IPR005474 Transketolase, N-terminal

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All nucleic 496

Genomic 1

cDNA 493

Primer pair 2

Microarray probesets 5

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MGD-MRK-33672

Summaries

All 47

Developmental Gene Expression 9

Gene Ontology 6

Phenotypes 10
Earliest

J:31736 Schimmer BP, et al., Amplification of the transketolase gene in desensitization-resistant mutant Y1 mouse adrenocortical tumor cells. J Biol Chem. 1996 Mar 1;271(9):4993-8
Latest

J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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