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Tkt
Gene Detail
Symbol

Name
ID
Tkt
transketolase
MGI:105992
Synonyms
p68
Feature Type
protein coding gene
Genetic Map
Chromosome 14
18.79 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:30548359-30574722 bp, + strand
From VEGA annotation of GRCm38

  26364 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68154  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TKT
Protein SuperFamily: transketolase
Gene Tree: Tkt

Human
homologs
TKT, transketolase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7086
neXtProt AC: NX_P29401

Human Synonyms: HEL107, TK, TKT1

Human Chr (Location): 3p14.3; chr3:53224707-53256114 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(32) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation die at or before the morula stage. Heterozygotes show reduced growth, decreased fat accumulation, microphthalmia, and reduced female fertility.
 
Interactions
Tkt interacts with 188 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process glyceraldehyde-3-phosphate biosynthetic process, metabolic process, ...
Component endoplasmic reticulum membrane, extracellular exosome, ...
Function carbohydrate binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (181)    Tissues (152)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 109
Northern blot 20
Western blot 6
RT-PCR 46
cDNA source data(493)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TKT ; Xenbase tkt ; ZFIN tktb    NEW 
Molecular
reagents
All nucleic(496) Genomic(1) cDNA(493) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000035018 (Evidence)
Ensembl Gene Model ENSMUSG00000021957 (Evidence)
Entrez Gene 21881 (Evidence)
UniGene 290692
DFCI TC1573822, TC1620951
DoTS DT.536649, DT.101404949, DT.101404947, DT.94124924
NIA Mouse Gene Index U015442
EC 2.2.1.1
Consensus CDS Project CCDS26894.1
International Mouse Phenotyping Consortium Status Tkt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035018 VEGA Gene Model | MGI Sequence Detail 26364 C57BL/6J ±  kb
transcript OTTMUST00000089041 VEGA | MGI Sequence Detail 3225 Not Applicable 
polypeptide OTTMUSP00000048606 VEGA | MGI Sequence Detail 623 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(3) UniProt(2)
Polymorphisms
SNPs within 2kb(244 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020826 Transketolase binding site
InterPro IPR005476 Transketolase, C-terminal
InterPro IPR009014 Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II
InterPro IPR005475 Transketolase-like, pyrimidine-binding domain
InterPro IPR005474 Transketolase, N-terminal
Protein Ontology PR:000016369 transketolase
References
(Earliest) J:31736 Schimmer BP, et al., Amplification of the transketolase gene in desensitization-resistant mutant Y1 mouse adrenocortical tumor cells. J Biol Chem. 1996 Mar 1;271(9):4993-8
(Latest) J:220406 Ishihara K, et al., Comparative proteomic profiling reveals aberrant cell proliferation in the brain of embryonic Ts1Cje, a mouse model of Down syndrome. Neuroscience. 2014 Sep 28;281C:1-15
All references(48)
Other
accession IDs
MGD-MRK-33672

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory