Tkt
Gene Detail

Symbol Name ID

Tkt transketolase MGI:105992

Synonyms

p68

Feature Type

protein coding gene

Genetic Map

Chromosome 14

18.79 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr14:30548359-30574722 bp, + strand From VEGA annotation of GRCm38   26364 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68154  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transketolase
Gene Tree: Tkt

Human homologs

Human Homolog		TKT, transketolase
NCBI Gene ID		7086
neXtProt AC		NX_P29401
Human Synonyms		HEL107, TK, TKT1
Human Chr (Location)		3p14.3; chr3:53224707-53256114 (-)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(36) : Gene trapped(32) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for a targeted null mutation die at or before the morula stage. Heterozygotes show reduced growth, decreased fat accumulation, microphthalmia, and reduced female fertility.

 

Interactions

Tkt interacts with 188 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	glyceraldehyde-3-phosphate biosynthetic process, metabolic process, ...
Component	endoplasmic reticulum membrane, extracellular vesicular exosome, ...
Function	carbohydrate binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (181)    Tissues (148)    Images (29)
Theiler Stages: 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	109
Northern blot	20
Western blot	6
RT-PCR	46

cDNA source data(493)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(496) Genomic(1) cDNA(493) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000035018 (Evidence)
Ensembl Gene Model	ENSMUSG00000021957 (Evidence)
Entrez Gene	21881 (Evidence)
UniGene	290692
DFCI	TC1573822, TC1620951
DoTS	DT.101404947, DT.101404949, DT.536649, DT.94124924
NIA Mouse Gene Index	U015442
EC	2.2.1.1
Consensus CDS Project	CCDS26894.1
International Mouse Knockout Project Status	Tkt

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035018	VEGA Gene Model | MGI Sequence Detail	26364	C57BL/6J
transcript	OTTMUST00000089041	VEGA | MGI Sequence Detail	3225	Not Applicable
polypeptide	OTTMUSP00000048606	VEGA | MGI Sequence Detail	623	Not Applicable

All sequences(79) RefSeq(3) UniProt(2)

Polymorphisms

SNPs within 2kb(244 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR020826	Transketolase binding site
InterPro	IPR005476	Transketolase, C-terminal
InterPro	IPR009014	Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II
InterPro	IPR005475	Transketolase-like, pyrimidine-binding domain
InterPro	IPR005474	Transketolase, N-terminal
Protein Ontology	PR:000016369	transketolase

References

(Earliest) J:31736 Schimmer BP, et al., Amplification of the transketolase gene in desensitization-resistant mutant Y1 mouse adrenocortical tumor cells. J Biol Chem. 1996 Mar 1;271(9):4993-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(47)

Other accession IDs

MGD-MRK-33672