About   Help   FAQ
Adam18
Gene Detail
 Symbol
Name
ID
Adam18
a disintegrin and metallopeptidase domain 18
MGI:105986
Synonyms Adam27, Dtgn3
Feature Type protein coding gene
Genetic Map
Chromosome 8
12.82 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:24602246-24674755 bp, - strand
From VEGA annotation of GRCm38

  72510 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74941  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Adam18

Human
homologs
Human Homolog ADAM18, ADAM metallopeptidase domain 18
NCBI Gene ID 8749
neXtProt AC  NX_Q9Y3Q7
Human Synonyms  ADAM27, tMDCIII
Human Chr (Location)  8p11.22; chr8:39584568-39730064 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit enhanced motor coordination during inverted screen testing when compared with that of controls.
 
Interactions
Adam18 interacts with 69 markers (Mir1b, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell differentiation, integrin-mediated signaling pathway, ...
Component extracellular region, integral component of membrane, ...
Function integrin binding, metalloendopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000025319 (Evidence)
Ensembl Gene ModelENSMUSG00000031552 (Evidence)
Entrez Gene13524 (Evidence)
UniGene89943
DFCITC1589155
DoTSDT.55195363
NIA Mouse Gene IndexU029653
Consensus CDS ProjectCCDS22195.1
International Mouse Knockout Project StatusAdam18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025319 VEGA Gene Model | MGI Sequence Detail 72510 C57BL/6J ±  kb
transcript OTTMUST00000062320 VEGA | MGI Sequence Detail 2361 Not Applicable 
polypeptide OTTMUSP00000030707 VEGA | MGI Sequence Detail 719 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(5) UniProt(5)
Polymorphisms SNPs within 2kb(437 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006586 ADAM, cysteine-rich
InterPro IPR001762 Blood coagulation inhibitor, Disintegrin
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR002870 Peptidase M12B, propeptide
Protein Ontology PR:000003713 disintegrin and metalloproteinase domain-containing protein 18
References (Earliest) J:30468 Weskamp G, et al., A family of cellular proteins related to snake venom disintegrins. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2748-51
(Latest) J:202837 Rowton M, et al., Regulation of mesenchymal-to-epithelial transition by PARAXIS during somitogenesis. Dev Dyn. 2013 Nov;242(11):1332-44
All references(30)
Other
accession IDs
MGD-MRK-33666

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory