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Adam18 Gene Detail
Summary
  • Symbol
    Adam18
  • Name
    a disintegrin and metallopeptidase domain 18
  • Synonyms
    Adam27, Dtgn3
  • Feature Type
    protein coding gene
  • IDs
    MGI:105986
    NCBI Gene: 13524
  • Gene Overview
    MyGene.info: ADAM18
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:24602246-24674755 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 12.82 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    410 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105986
protein coding gene Chr8:24602246-24674755 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033472
protein coding gene Chr8:22599171-22676268 (-)
A/J MGP_AJ_G0033452
protein coding gene Chr8:21813275-21878542 (-)
AKR/J MGP_AKRJ_G0033377
protein coding gene Chr8:22530186-22605116 (-)
BALB/cJ MGP_BALBcJ_G0033448
protein coding gene Chr8:21946720-22036625 (-)
C3H/HeJ MGP_C3HHeJ_G0033162
protein coding gene Chr8:22722722-22791820 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033964
protein coding gene Chr8:23502986-23575255 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030914
protein coding gene Chr8:19123121-19190319 (-)
CAST/EiJ MGP_CASTEiJ_G0032488
protein coding gene Chr8:22144976-22211191 (-)
CBA/J MGP_CBAJ_G0033137
protein coding gene Chr8:24438921-24518372 (-)
DBA/2J MGP_DBA2J_G0033292
protein coding gene Chr8:21781721-21850235 (-)
FVB/NJ MGP_FVBNJ_G0033236
protein coding gene Chr8:21574498-21635804 (-)
LP/J MGP_LPJ_G0033381
protein coding gene Chr8:22596281-22664544 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033279
protein coding gene Chr8:23963612-24044779 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033983
protein coding gene Chr8:22457742-22524057 (-)
PWK/PhJ MGP_PWKPhJ_G0032199
protein coding gene Chr8:21390530-21455112 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032033
protein coding gene Chr8:21815864-21879035 (-)
WSB/EiJ MGP_WSBEiJ_G0032604
protein coding gene Chr8:22670343-22738108 (-)



Homology
more
  • Human Ortholog
    ADAM18, ADAM metallopeptidase domain 18
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ADAM18, ADAM metallopeptidase domain 18
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADAM27, tMDCIII
  • Links
    NCBI Gene ID: 8749
    neXtProt AC: NX_Q9Y3Q7
    UniProt: Q9Y3Q7

  • Chr Location
    8p11.22; chr8:39584568-39730064 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit enhanced motor coordination during inverted screen testing when compared with that of controls.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13524 NCBI Gene Model | MGI Sequence Detail 72510 C57BL/6J ±  kb
transcript NM_010084 RefSeq | MGI Sequence Detail 2361 C57BL/6  
polypeptide Q9R157 UniProt | EBI | MGI Sequence Detail 719 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-33666
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:30468 Weskamp G, et al., A family of cellular proteins related to snake venom disintegrins. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2748-51
  • Latest
    J:234235 Miyata H, et al., Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7704-10

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory