About   Help   FAQ
Rfx1
Gene Detail
 Symbol
Name
ID
Rfx1
regulatory factor X, 1 (influences HLA class II expression)
MGI:105982
Feature Type protein coding gene
Genetic Map
Chromosome 8
40.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:84066836-84096992 bp, + strand
From NCBI annotation of GRCm38

  30157 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2189  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 zebrafish

Gene Tree: Rfx1

Human
homologs
Human Homolog RFX1, regulatory factor X, 1 (influences HLA class II expression)
NCBI Gene ID 5989
neXtProt AC  NX_P22670
Human Synonyms  EFC, RFX
Human Chr (Location)  19p13.1; chr19:13961530-14007083 (-)  GRCh38
Alleles
and
phenotypes
All alleles(20) : Gene trapped(18) Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for a gene trap allele die prior to implantation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process regulation of transcription, DNA-templated, transcription, DNA-templated
Component nucleus
Function DNA binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (73)    Tissues (65)    Images (11)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 21, 23, 27, 28
Assay TypeResults
RNA in situ 58
RT-PCR 15
cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(58) cDNA(55) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000031706 (Evidence)
Entrez Gene19724 (Evidence)
UniGene7892
DFCITC1580812
DoTSDT.101222175, DT.40180932
NIA Mouse Gene IndexU009566
Consensus CDS ProjectCCDS22468.1
International Mouse Knockout Project StatusRfx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19724 NCBI Gene Model | MGI Sequence Detail 30157 C57BL/6J ±  kb
transcript NM_009055 RefSeq | MGI Sequence Detail 4179 C57BL/6 
polypeptide P48377 UniProt | EBI | MGI Sequence Detail 963 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(12) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(334 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003150 DNA-binding RFX-type winged-helix domain
InterPro IPR007668 RFX1 transcription activation region
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000013923 MHC class II regulatory factor RFX1
Graphical View of Protein Domain Structure
References (Earliest) J:15188 Safrany G, et al., Transcription factor RFX1 helps control the promoter of the mouse ribosomal protein-encoding gene rpL30 by binding to its alpha element. Gene. 1993 Oct 15;132(2):279-83
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(43)
Other
accession IDs
MGD-MRK-33662, MGI:2142460, MGI:2142518

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory