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Rfx1
Gene Detail
Symbol

Name
ID
Rfx1
regulatory factor X, 1 (influences HLA class II expression)
MGI:105982
Feature Type
protein coding gene
Genetic Map
Chromosome 8
40.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:84066836-84096992 bp, + strand
From Ensembl annotation of GRCm38

  30157 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2189  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RFX1
Gene Tree: Rfx1

Human
homologs
RFX1, regulatory factor X, 1 (influences HLA class II expression)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5989
neXtProt AC: NX_P22670

Human Synonyms: EFC, RFX

Human Chr (Location): 19p13.1; chr19:13961530-14007514 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(18) Targeted(2)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a gene trap allele die prior to implantation.
 
Interactions
Rfx1 interacts with 194 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (66)    Tissues (62)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 58
RT-PCR 8
cDNA source data(51)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rfx1 ; ZFIN rfx1b    NEW 
Molecular
reagents
All nucleic(58) cDNA(55) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000031706 (Evidence)
Entrez Gene 19724 (Evidence)
UniGene 7892
DFCI TC1580812
DoTS DT.101222175, DT.40180932
NIA Mouse Gene Index U009566
Consensus CDS Project CCDS22468.1
International Mouse Phenotyping Consortium Status Rfx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031706 Ensembl Gene Model | MGI Sequence Detail 30157 C57BL/6J ±  kb
transcript ENSMUST00000005600 Ensembl | MGI Sequence Detail 4172 Not Applicable 
polypeptide ENSMUSP00000005600 Ensembl | MGI Sequence Detail 963 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(14) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(334 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003150 DNA-binding RFX-type winged-helix domain
InterPro IPR007668 RFX1 transcription activation region
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000013923 MHC class II regulatory factor RFX1
References
(Earliest) J:15188 Safrany G, et al., Transcription factor RFX1 helps control the promoter of the mouse ribosomal protein-encoding gene rpL30 by binding to its alpha element. Gene. 1993 Oct 15;132(2):279-83
(Latest) J:209144 Bae BI, et al., Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. Science. 2014 Feb 14;343(6172):764-8
All references(45)
Other
accession IDs
MGD-MRK-33662, MGI:2142460, MGI:2142518

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory