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Cntn1
Gene Detail
 Symbol
Name
ID
Cntn1
contactin 1
MGI:105980
Synonyms CNTN, F3cam
Feature Type protein coding gene
Genetic Map
Chromosome 15
46.39 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr15:92051165-92341953 bp, + strand
From VEGA annotation of GRCm38

  290789 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7274  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cntn1

Human
homologs
Human Homolog CNTN1, contactin 1
NCBI Gene ID 1272
neXtProt AC  NX_Q12860
Human Synonyms  F3, GP135
Human Chr (Location)  12q11-q12; chr12:40692442-41072412 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CNTN1
Alleles
and
phenotypes
All alleles(5) : Gene trapped(1) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations of this gene result in growth retardation, progressive ataxia and death prior to weaning. A targeted null mutation, but not the spontaneous mutation, causes a small cerebellum with abnormalities of the molecular layer and abnormal Purkinje cell axon morphology.
 
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell adhesion, cerebellum development, ...
Component anchored component of membrane, extracellular vesicular exosome, ...
Function carbohydrate binding, glycoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (495)    Tissues (183)    Images (42)
Theiler Stages: 21, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 455
RT-PCR 36
RNase protection 3
cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(27) Genomic(2) cDNA(21) Primer pair(4)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000014988 (Evidence)
Ensembl Gene ModelENSMUSG00000055022 (Evidence)
Entrez Gene12805 (Evidence)
DFCITC1583100, TC1593148, TC1597628, TC1636116, TC1671082
DoTSDT.101150259, DT.101718408, DT.110811325, DT.97404357, DT.99849974
NIA Mouse Gene IndexU016587
Consensus CDS ProjectCCDS27763.1
International Mouse Knockout Project StatusCntn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014988 VEGA Gene Model | MGI Sequence Detail 290789 C57BL/6J ±  kb
transcript OTTMUST00000035589 VEGA | MGI Sequence Detail 3964 Not Applicable 
polypeptide OTTMUSP00000015954 VEGA | MGI Sequence Detail 1020 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(8) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(2884 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000005666 contactin-1
References (Earliest) J:9923 Gennarini G, et al., The mouse neuronal cell surface protein F3: a phosphatidylinositol-anchored member of the immunoglobulin superfamily related to chicken contactin. J Cell Biol. 1989 Aug;109(2):775-88
(Latest) J:206362 Colakoglu G, et al., Contactin-1 regulates myelination and nodal/paranodal domain organization in the central nervous system. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E394-403
All references(71)
Other
accession IDs
MGD-MRK-33660, MGD-MRK-9694, MGI:2146221

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory