Cntn1
Gene Detail

Symbol Name ID

Cntn1 contactin 1 MGI:105980

Synonyms

CNTN, F3cam

Feature Type

protein coding gene

Genetic Map

Chromosome 15

46.39 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr15:92051165-92341953 bp, + strand From VEGA annotation of GRCm38   290789 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7274  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cntn1

Human homologs

Human Homolog		CNTN1, contactin 1
NCBI Gene ID		1272
neXtProt AC		NX_Q12860
Human Synonyms		F3, GP135
Human Chr (Location)		12q11-q12; chr12:41086244-41466214 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CNTN1

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(1) Spontaneous(1)
 

Mutations of this gene result in growth retardation, progressive ataxia and death prior to weaning. A targeted null mutation, but not the spontaneous mutation, causes a small cerebellum with abnormalities of the molecular layer and abnormal Purkinje cell axon morphology.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	cell adhesion, cerebellum development, ...
Component	anchored to membrane, membrane, ...
Function	carbohydrate binding, glycoprotein binding

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (446)    Tissues (134)    Images (40)
Theiler Stages: 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	406
RT-PCR	36
RNase protection	3

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(2) cDNA(21) Primer pair(4)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000014988 (Evidence)
Ensembl Gene Model	ENSMUSG00000055022 (Evidence)
Entrez Gene	12805 (Evidence)
DFCI	TC1583100, TC1593148, TC1597628, TC1636116, TC1671082
DoTS	DT.101150259, DT.101718408, DT.110811325, DT.97404357, DT.99849974
NIA Mouse Gene Index	U016587
Consensus CDS Project	CCDS27763.1
International Mouse Knockout Project Status	Cntn1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014988	VEGA Gene Model | MGI Sequence Detail	290789	C57BL/6J
transcript	OTTMUST00000035588	VEGA | MGI Sequence Detail	5646	Not Applicable
polypeptide	OTTMUSP00000015953	VEGA | MGI Sequence Detail	1020	Not Applicable

All sequences(54) RefSeq(6) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(1331 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
Protein Ontology	PR:000005666	contactin-1

References

(Earliest) J:9923 Gennarini G, et al., The mouse neuronal cell surface protein F3: a phosphatidylinositol-anchored member of the immunoglobulin superfamily related to chicken contactin. J Cell Biol. 1989 Aug;109(2):775-88
(Latest) J:193910 Bormuth I, et al., Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions. J Neurosci. 2013 Jan 9;33(2):641-51
All references(69)

Other accession IDs

MGD-MRK-33660, MGD-MRK-9694, MGI:2146221