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Myo5a
Gene Detail
Symbol

Name
ID
Myo5a
myosin VA
MGI:105976
Synonyms
9630007J19Rik, Dbv, flail, MVa, Myo5, MyoVA, nmf244
Feature Type
protein coding gene
Genetic Map
Chromosome 9
42.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(155)
Sequence Map
Chr9:75071015-75223688 bp, + strand
From VEGA annotation of GRCm38

  152674 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20100  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Myo5a

Human
homologs
Human Homolog MYO5A, myosin VA (heavy chain 12, myoxin)
NCBI Gene ID 4644
neXtProt AC  NX_Q9Y4I1
Human Synonyms  GS1, MYH12, MYO5, MYR12
Human Chr (Location)  15q21; chr15:52307283-52529050 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MYO5A
Mutations,
alleles, and
phenotypes
All mutations/alleles(95) : Chemically and radiation induced(1) Chemically induced (ENU)(24) Gene trapped(3) Radiation induced(11) Spontaneous(53) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene cause abnormal melanocyte structure, resulting in clumping of melanin pigment in hair of nonagouti mice, producing a gray coat color. Some alleles also produce a lethal or neurological phenotype. Normal melanocyte structure and coat phenotype is restored in revertant alleles.
 
Human Diseases Modeled Using Mouse Myo5a (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(5)
Interactions
Myo5a interacts with 481 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (103 annotations)
Process actin filament-based movement, anagen, ...
Component actin filament, actomyosin, ...
Function actin binding, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (104)    Tissues (39)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 104
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) Genomic(19) cDNA(23) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000016492 (Evidence)
Ensembl Gene ModelENSMUSG00000034593 (Evidence)
Entrez Gene17918 (Evidence)
DFCITC1578470, TC1603039, TC1601670
NIA Mouse Gene IndexU010743
PDB4KP3, 3WB8, 2IX7
Consensus CDS ProjectCCDS52860.1
International Mouse Knockout Project StatusMyo5a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016492 VEGA Gene Model | MGI Sequence Detail 152674 C57BL/6J ±  kb
transcript OTTMUST00000042678 VEGA | MGI Sequence Detail 6372 Not Applicable 
polypeptide OTTMUSP00000019176 VEGA | MGI Sequence Detail 1855 Not Applicable 

For the selected sequences
All sequences(93) RefSeq(18) UniProt(13)
Polymorphisms
RFLP(17) : SNPs within 2kb(455 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018444 Dil domain
InterPro IPR002710 Dilute
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR008989 Myosin S1 fragment, N-terminal
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010865 myosin-Va
References
(Earliest) J:28864 Gates WH, Linkage of Short Ear and Density in the House Mouse. Proc Natl Acad Sci U S A. 1927 Aug;13(8):575-8
(Latest) J:212958 Chaudhury A, et al., Myosin Va plays a role in nitrergic smooth muscle relaxation in gastric fundus and corpora cavernosa of penis. PLoS One. 2014;9(2):e86778
All references(273)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14365, MGD-MRK-2338, MGD-MRK-28030, MGD-MRK-33656, MGD-MRK-8805, MGI:1096356, MGI:1343057, MGI:2143030, MGI:2143108

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory