About   Help   FAQ
Myo5a
Gene Detail
 Symbol
Name
ID
Myo5a
myosin VA
MGI:105976
Synonyms 9630007J19Rik, Dbv, flail, MVa, Myo5, MyoVA, nmf244
Feature Type protein coding gene
Genetic Map
Chromosome 9
42.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(155)
Sequence Map
Chr9:75071015-75223688 bp, + strand
From VEGA annotation of GRCm38

  152674 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20100  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Myo5a

Human
homologs
Human Homolog MYO5A, myosin VA (heavy chain 12, myoxin)
NCBI Gene ID 4644
neXtProt AC  NX_Q9Y4I1
Human Synonyms  GS1, MYH12, MYO5, MYR12
Human Chr (Location)  15q21; chr15:52307283-52529050 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MYO5A
Alleles
and
phenotypes
All alleles(95) : Chemically and radiation induced(1) Chemically induced (ENU)(24) Gene trapped(3) Radiation induced(11) Spontaneous(53) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene cause abnormal melanocyte structure, resulting in clumping of melanin pigment in hair of nonagouti mice, producing a gray coat color. Some alleles also produce a lethal or neurological phenotype. Normal melanocyte structure and coat phenotype is restored in revertant alleles.
 
Human Diseases Modeled Using Mouse Myo5a (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(5)
Gene Ontology
(GO)
classifications
All GO classifications: (89 annotations)
Process actin filament-based movement, anagen, ...
Component actomyosin, actomyosin, myosin complex part, ...
Function actin binding, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (104)    Tissues (39)    Images (30)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 104
cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(44) Genomic(19) cDNA(23) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000016492 (Evidence)
Ensembl Gene ModelENSMUSG00000034593 (Evidence)
Entrez Gene17918 (Evidence)
DFCITC1578470, TC1601670, TC1603039
NIA Mouse Gene IndexU010743
PDB2IX7, 3WB8, 4KP3
Consensus CDS ProjectCCDS52860.1
International Mouse Knockout Project StatusMyo5a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016492 VEGA Gene Model | MGI Sequence Detail 152674 C57BL/6J ±  kb
transcript OTTMUST00000042678 VEGA | MGI Sequence Detail 6372 Not Applicable 
polypeptide OTTMUSP00000019176 VEGA | MGI Sequence Detail 1855 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(18) UniProt(7)
Polymorphisms RFLP(17) : SNPs within 2kb(455 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018444 Dil domain
InterPro IPR002710 Dilute
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR008989 Myosin S1 fragment, N-terminal
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010865 myosin-Va
References (Earliest) J:28864 Gates WH, Linkage of Short Ear and Density in the House Mouse. Proc Natl Acad Sci U S A. 1927 Aug;13(8):575-8
(Latest) J:198812 Wei Z, et al., Structural basis of cargo recognitions for class V myosins. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11314-9
All references(272)
Other
accession IDs
MGD-MRK-14365, MGD-MRK-2338, MGD-MRK-28030, MGD-MRK-33656, MGD-MRK-8805, MGI:1096356, MGI:1343057, MGI:2143030, MGI:2143108

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory