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Cox8a Gene Detail
Summary
  • Symbol
    Cox8a
  • Name
    cytochrome c oxidase subunit VIIIa
  • Synonyms
    COX8L, COX VIII-L
  • Feature Type
    protein coding gene
  • IDs
    MGI:105959
    NCBI Gene: 12868
Location & Maps
more
  • Genetic Map
    Chromosome 19, 5.28 cM, cytoband A
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    COX8A, cytochrome c oxidase subunit 8A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    COX8A, cytochrome c oxidase subunit 8A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    COX, COX8, COX8-2, COX8L, VIII, VIII-L
  • Links
    NCBI Gene ID: 1351
    neXtProt AC: NX_P10176

  • Chr Location
    11q13.1; chr11:63974607-63976543 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from multigenic genotypes
    8 phenotype references
  • All Mutations and Alleles
    32
  • Gene trapped
    29
  • Targeted
    2
  • Transgenic
    1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12868 NCBI Gene Model | MGI Sequence Detail 2459 C57BL/6J ±  kb
transcript NM_007750 RefSeq | MGI Sequence Detail 545 C57BL/6  
polypeptide Q64445 UniProt | EBI | MGI Sequence Detail 69 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    19 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005792 cytochrome c oxidase subunit 8A, mitochondrial
  • InterPro Domains
    IPR003205 Cytochrome c oxidase, subunit 8
    IPR016070 Cytochrome c oxidase subunit VIII/photosystem I reaction centre subunit IX
Molecular
Reagents
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  • All nucleic 408
    cDNA 406
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-33638
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:22802 Lomax MI, et al., Structure and chromosomal location of the bovine gene for the heart muscle isoform of cytochrome c oxidase subunit VIII. Mamm Genome. 1995 Feb;6(2):118-22
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory