Mpp1
Gene Detail

Symbol Name ID

Mpp1 membrane protein, palmitoylated MGI:105941

Synonyms

55kDa, C130070C03Rik, erythrocyte protein p55, p55

Feature Type

protein coding gene

Genetic Map

Chromosome X

38.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

ChrX:75109733-75131016 bp, - strand From VEGA annotation of GRCm38   21284 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1826  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mpp1

Human homologs

Human Homolog		MPP1, membrane protein, palmitoylated 1, 55kDa
NCBI Gene ID		4354
neXtProt AC		NX_Q00013
Human Synonyms		AAG12, DXS552E, EMP55, MRG1, PEMP
Human Chr (Location)		Xq28; chrX:154006959-154033802 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Mice homozygous for a knock-out allele display defects in neutrophil polarity and chemotaxis and produce small litters of pups.

 

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	regulation of neutrophil chemotaxis
Component	cell projection, cortical cytoskeleton, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (28)    Tissues (22)   
Theiler Stages: 20, 22, 24, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	24
Western blot	2

cDNA source data(105)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(109) Genomic(2) cDNA(107)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000020789 (Evidence)
Ensembl Gene Model	ENSMUSG00000031402 (Evidence)
Entrez Gene	17524 (Evidence)
UniGene	391267
DFCI	TC1572952
DoTS	DT.101402211, DT.101717721, DT.494700, DT.97415304
NIA Mouse Gene Index	U039477
Consensus CDS Project	CCDS30236.1
International Mouse Knockout Project Status	Mpp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020789	VEGA Gene Model | MGI Sequence Detail	21284	C57BL/6J
transcript	OTTMUST00000049155	VEGA | MGI Sequence Detail	2525	Not Applicable
polypeptide	OTTMUSP00000022728	VEGA | MGI Sequence Detail	466	Not Applicable

All sequences(72) RefSeq(2) UniProt(10)

Polymorphisms

RFLP(1) : SNPs(61 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008144	Guanylate kinase
InterPro	IPR020590	Guanylate kinase, conserved site
InterPro	IPR008145	Guanylate kinase/L-type calcium channel
InterPro	IPR001478	PDZ domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR011511	Variant SH3
Protein Ontology	PR:000010544	55 kDa erythrocyte membrane protein

References

(Earliest) J:31964 Peters LL, et al., Localization of the gene encoding the erythrocyte membrane protein p55 (Mpp1) on the mouse X Chromosome. Mamm Genome. 1996 Mar;7(3):245-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)

Other accession IDs

MGD-MRK-33620, MGI:2444970