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Mpp1
Gene Detail
Symbol

Name
ID
Mpp1
membrane protein, palmitoylated
MGI:105941
Synonyms
55kDa, C130070C03Rik, erythrocyte protein p55, p55
Feature Type
protein coding gene
Genetic Map
Chromosome X
38.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:75109733-75131016 bp, - strand
From VEGA annotation of GRCm38

  21284 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1826  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MPP1
Gene Tree: Mpp1

Human
homologs
MPP1, membrane protein, palmitoylated 1, 55kDa
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4354
neXtProt AC: NX_Q00013

Human Synonyms: AAG12, DXS552E, EMP55, MRG1, PEMP

Human Chr (Location): Xq28; chrX:154778684-154805527 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display defects in neutrophil polarity and chemotaxis and produce small litters of pups.
 
Interactions
Mpp1 interacts with 181 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process regulation of neutrophil chemotaxis
Component cell projection, cortical cytoskeleton, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (28)    Tissues (22)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 24
Western blot 2
cDNA source data(105)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mpp1    NEW 
Molecular
reagents
All nucleic(109) Genomic(2) cDNA(107)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000020789 (Evidence)
Ensembl Gene Model ENSMUSG00000031402 (Evidence)
Entrez Gene 17524 (Evidence)
UniGene 391267
DFCI TC1572952
DoTS DT.101402211, DT.101717721, DT.494700, DT.97415304
NIA Mouse Gene Index U039477
Consensus CDS Project CCDS30236.1
International Mouse Phenotyping Consortium Status Mpp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020789 VEGA Gene Model | MGI Sequence Detail 21284 C57BL/6J ±  kb
transcript OTTMUST00000049155 VEGA | MGI Sequence Detail 2525 Not Applicable 
polypeptide OTTMUSP00000022728 VEGA | MGI Sequence Detail 466 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(2) UniProt(10)
Polymorphisms
RFLP(1) : SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020590 Guanylate kinase, conserved site
InterPro IPR008144 Guanylate kinase-like domain
InterPro IPR008145 Guanylate kinase/L-type calcium channel beta subunit
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 SH3 domain
InterPro IPR011511 Variant SH3 domain
Protein Ontology PR:000010544 55 kDa erythrocyte membrane protein
References
(Earliest) J:31964 Peters LL, et al., Localization of the gene encoding the erythrocyte membrane protein p55 (Mpp1) on the mouse X Chromosome. Mamm Genome. 1996 Mar;7(3):245-6
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)
Other
accession IDs
MGD-MRK-33620, MGI:2444970

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory