Rab5b MGI Mouse Gene Detail - MGI:105938 - RAB5B, member RAS oncogene family

Symbol

Rab5b
Name

RAB5B, member RAS oncogene family
Synonyms

C030027M18Rik

Feature Type

protein coding gene
IDs

MGI:105938
NCBI Gene: 19344
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:128513044-128532133 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 77.13 cM
Mapping Data

5 experiments

SNPs within 2kb

389 from dbSNP Build 142
Strain Annotations

27
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105938	protein coding gene	Chr10:128511980-128532160 (-)
129S1/SvImJ	ENSMUSG00200042861	protein coding gene	Chr2:113283938-113286393 (-)
129S1/SvImJ	ENSMUSG00200011333	protein coding gene	Chr10:124871138-124890229 (-)
A/J	ENSMUSG00195023591	protein coding gene	Chr2:113339724-113341051 (-)
A/J	ENSMUSG00195014008	protein coding gene	Chr10:125334425-125353520 (-)
AKR/J	ENSMUSG00220004848	protein coding gene	Chr10:124939630-124958713 (-)
BALB/cJ	ENSMUSG00180037873	protein coding gene	Chr2:113139293-113140311 (-)
BALB/cJ	ENSMUSG00180009143	protein coding gene	Chr10:125325415-125344513 (-)
C3H/HeJ	ENSMUSG00175005542	protein coding gene	Chr10:125324869-125343952 (-)
C57BL/6NJ	ENSMUSG00215011763	protein coding gene	Chr10:124931533-124950624 (-)
C57BL/6NJ	ENSMUSG00215027530	protein coding gene	Chr2:113272236-113273599 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015949	protein coding gene	Chr10:121040883-121047000 (-)
CAST/EiJ	ENSTCUG00005037045	protein coding gene	Chr10:124317585-124336701 (-)
CBA/J	ENSMUSG00210007651	protein coding gene	Chr10:125149074-125168158 (-)
DBA/2J	ENSMUSG00185040855	protein coding gene	Chr2:113134393-113137087 (-)
DBA/2J	ENSMUSG00185024689	protein coding gene	Chr10:125298623-125317712 (-)
FVB/NJ	ENSMUSG00205012331	protein coding gene	Chr10:124540040-124559136 (-)
JF1/MsJ	ENSUMUG00000034099	protein coding gene	Chr10:126608233-126627324 (-)
LP/J	ENSMUSG00230030126	protein coding gene	Chr10:127224400-127243485 (-)
LP/J	ENSMUSG00230014943	protein coding gene	Chr2:114945212-114946287 (-)
NOD/ShiLtJ	ENSMUSG00190040207	protein coding gene	Chr2:113337980-113339343 (-)
NOD/ShiLtJ	ENSMUSG00190014791	protein coding gene	Chr10:125362235-125381328 (-)
NZO/HlLtJ	ENSMUSG00225037112	protein coding gene	Chr10:131423193-131442283 (-)
NZO/HlLtJ	ENSMUSG00225002951	protein coding gene	Chr2:122822396-122825090 (-)
PWK/PhJ	ENSLUMG00010009533	protein coding gene	Chr10:125064637-125083749 (-)
SPRET/EiJ	ENSMSPG00010026691	protein coding gene	Chr10:127022963-127042043 (-)
WSB/EiJ	ENSIUOG00005008378	protein coding gene	Chr10:124946168-124965267 (-)

Human Ortholog

RAB5B, RAB5B, member RAS oncogene family

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB5B, RAB5B, member RAS oncogene family
Links

HGNC:9784

NCBI Gene ID: 5869

UniProt: P61020
Chr Location

12q13.2; chr12:55973913-55996683 (+) GRCh38

MGI Vertebrate Homology

Rab5b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAB5B
Gene Tree

Rab5b

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Endonuclease-mediated

4
Gene trapped

26
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

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All GO Annotations

52
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

641
Tissues

29
cDNA Data

7
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab5b

ZFIN rab5b

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All Sequences

67
RefSeq

6
UniProt

4
CCDS

CCDS24287.1

Ensembl

ENSMUSG00000000711 (Evidence)
NCBI Gene

19344

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000711	Ensembl Gene Model \| MGI Sequence Detail	19090	C57BL/6J	± kb
transcript	ENSMUST00000000727	Ensembl \| MGI Sequence Detail	3180	Not Applicable
polypeptide	ENSMUSP00000000727	Ensembl \| MGI Sequence Detail	215	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013634 Ras-related protein Rab-5B

(term hierarchy)
EC

3.6.5.2
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR005225 Small GTP-binding domain
GlyGen

P61021 1 site, 1 O-linked glycan (1 site)

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All nucleic 9

cDNA 7

Primer pair 1

Other 1

Microarray probesets 4

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MGD-MRK-33617, MGI:2444434

Summaries

All 57

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 12
Earliest

J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rab5b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99929	Chr10:128533970-128533975 (-)	-1,840 bp
Tssr99928	Chr10:128532126-128532142 (-)	-1 bp
Tssr99927	Chr10:128532083-128532125 (-)	29 bp
Tssr99926	Chr10:128532052-128532059 (-)	77 bp
Tssr99925	Chr10:128531879-128531934 (-)	226 bp
Tssr99924	Chr10:128531860-128531872 (-)	267 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24