Rab3ip MGI Mouse Gene Detail - MGI:105933 - RAB3A interacting protein

Symbol

Rab3ip
Name

RAB3A interacting protein
Synonyms

Gtpat12, Rabin3, SSX2 interacting protein

Feature Type

protein coding gene
IDs

MGI:105933
NCBI Gene: 216363
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:116741685-116786361 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 64.96 cM
Mapping Data

1 experiment

SNPs within 2kb

1716 from dbSNP Build 142
Strain Annotations

19
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105933	protein coding gene	Chr10:116741685-116786674 (-)
129S1/SvImJ	ENSMUSG00200024875	protein coding gene	Chr10:113151626-113196613 (-)
A/J	ENSMUSG00195020877	protein coding gene	Chr10:113586372-113631365 (-)
AKR/J	ENSMUSG00220014639	protein coding gene	Chr10:113160020-113204989 (-)
BALB/cJ	ENSMUSG00180016008	protein coding gene	Chr10:113603288-113648288 (-)
C3H/HeJ	ENSMUSG00175023787	protein coding gene	Chr10:113548204-113593189 (-)
C57BL/6NJ	ENSMUSG00215011807	protein coding gene	Chr10:113244606-113289591 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015824	protein coding gene	Chr10:109687945-109734385 (-)
CAST/EiJ	ENSTCUG00005029477	protein coding gene	Chr10:112565726-112610915 (-)
CBA/J	ENSMUSG00210020501	protein coding gene	Chr10:113397768-113442755 (-)
DBA/2J	ENSMUSG00185008276	protein coding gene	Chr10:113522685-113567673 (-)
FVB/NJ	ENSMUSG00205023478	protein coding gene	Chr10:112847257-112892251 (-)
JF1/MsJ	ENSUMUG00000013058	protein coding gene	Chr10:114838947-114883986 (-)
LP/J	ENSMUSG00230022468	protein coding gene	Chr10:115472134-115517128 (-)
NOD/ShiLtJ	ENSMUSG00190017692	protein coding gene	Chr10:113647845-113692830 (-)
NZO/HlLtJ	ENSMUSG00225017461	protein coding gene	Chr10:119726508-119771493 (-)
PWK/PhJ	ENSLUMG00010012859	protein coding gene	Chr10:113226986-113269899 (-)
SPRET/EiJ	ENSMSPG00010015167	protein coding gene	Chr10:115168887-115213055 (-)
WSB/EiJ	ENSIUOG00005013259	protein coding gene	Chr10:113239622-113284555 (-)

Human Ortholog

RAB3IP, RAB3A interacting protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB3IP, RAB3A interacting protein
Synonyms

RABIN3, RABIN8
Links

HGNC:16508

NCBI Gene ID: 117177

UniProt: Q96QF0
Chr Location

12q15; chr12:69738242-69823204 (+) GRCh38

MGI Vertebrate Homology

Rab3ip stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAB3IP
Gene Tree

Rab3ip

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Gene trapped

17
Targeted

4
Genomic Mutations

1 involving Rab3ip
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are fertile and show no obvious abnormalities.

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All GO Annotations

37
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

65
cDNA Data

63
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab3ip

ZFIN rab3ip

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All Sequences

67
RefSeq

16
UniProt

5
CCDS

CCDS24186.1, CCDS88090.1

Ensembl

ENSMUSG00000064181 (Evidence)
NCBI Gene

216363

			Length	Strain/Species	Flank
genomic	216363	NCBI Gene Model \| MGI Sequence Detail	44677	C57BL/6J	± kb
transcript	NM_001359645	RefSeq \| MGI Sequence Detail	2880	ZRU/MplStud
polypeptide	Q68EF0	UniProt \| EBI \| MGI Sequence Detail	428	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013624 Rab-3A-interacting protein

(term hierarchy)
InterPro Domains

IPR009449 GDP/GTP exchange factor Sec2, N-terminal

IPR040351 Guanine nucleotide exchange factor RAB3IL/RAB3IP/Sec2
GlyGen

Q68EF0 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 67

cDNA 64

Primer pair 3

Microarray probesets 4

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MGD-MRK-33612

Summaries

All 49

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rab3ip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99379	Chr10:116786350-116786361 (-)	5 bp
Tssr99378	Chr10:116786271-116786337 (-)	57 bp
Tssr99377	Chr10:116767756-116767772 (-)	18,597 bp
Tssr99376	Chr10:116761984-116762007 (-)	24,365 bp
Tssr99375	Chr10:116755544-116755563 (-)	30,807 bp
Tssr99374	Chr10:116754830-116754836 (-)	31,528 bp
Tssr99373	Chr10:116749777-116749806 (-)	36,569 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24