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Sycp1
Gene Detail
Symbol

Name
ID
Sycp1
synaptonemal complex protein 1
MGI:105931
Synonyms
SCP1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
45.25 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:102818499-102936100 bp, - strand
From NCBI annotation of GRCm38

  117602 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2389  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sycp1

Human
homologs
Human Homolog SYCP1, synaptonemal complex protein 1
NCBI Gene ID 6847
neXtProt AC  NX_Q15431
Human Synonyms  CT8, HOM-TES-14, SCP1, SCP-1
Human Chr (Location)  1p13-p12; chr1:114854803-114995370 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display male and female infertility, azoospermia, small ovary, small testis and seminiferous tubules, absent ovarian follicles, and failure of synapse formation during meiosis.
 
Interactions
Sycp1 interacts with 101 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cell cycle, cell division, ...
Component central element, chromosome, ...
Function DNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (88)    Tissues (55)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 23
RNA in situ 26
Western blot 6
RT-PCR 33
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(4) cDNA(26) Primer pair(5)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000027855 (Evidence)
Entrez Gene20957 (Evidence)
UniGene243849
DoTSDT.40140555
Consensus CDS ProjectCCDS38567.1
International Mouse Knockout Project StatusSycp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20957 NCBI Gene Model | MGI Sequence Detail 117602 C57BL/6J ±  kb
transcript NM_011516 RefSeq | MGI Sequence Detail 3437 C57BL/6 
polypeptide Q62209 UniProt | EBI | MGI Sequence Detail 993 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(10) UniProt(1)
Polymorphisms
RFLP(5) : SNPs within 2kb(330 from dbSNP Build 137)    SNPs within 2kb including multiple locations(336)
Protein-related
information
ResourceIDDescription
InterPro IPR008827 Synaptonemal complex 1
Protein Ontology PR:000015862 synaptonemal complex protein 1
Graphical View of Protein Domain Structure
References
(Earliest) J:28808 Sage J, et al., cDNA sequence of the murine synaptonemal complex protein 1 (SCP1). Biochim Biophys Acta. 1995 Sep 19;1263(3):258-60
(Latest) J:211664 Winters T, et al., Meiotic cohesin STAG3 is required for chromosome axis formation and sister chromatid cohesion. EMBO J. 2014 Jun 2;33(11):1256-70
All references(81)
Other
accession IDs
MGD-MRK-33610

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory