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Cdo1 Gene Detail
Summary
  • Symbol
    Cdo1
  • Name
    cysteine dioxygenase 1, cytosolic
  • Synonyms
    1300002L19Rik, Cdo, D18Ucla3
  • Feature Type
    protein coding gene
  • IDs
    MGI:105925
    NCBI Gene: 12583
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:46846260-46861462 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 24.75 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    466 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105925
 protein coding gene Chr18:46846260-46861569 (-)
129S1/SvImJ ENSMUSG00200029848
 protein coding gene Chr18:43865986-43881192 (-)
A/J ENSMUSG00195024698
 protein coding gene Chr18:44044491-44059697 (-)
AKR/J ENSMUSG00220020650
 protein coding gene Chr18:43994358-44009564 (-)
BALB/cJ ENSMUSG00180007360
 protein coding gene Chr18:44533732-44548932 (-)
C3H/HeJ ENSMUSG00175010518
 protein coding gene Chr18:44051686-44066886 (-)
C57BL/6NJ ENSMUSG00215007863
 protein coding gene Chr18:43731514-43746718 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022257
 protein coding gene Chr18:43708025-43723399 (-)
CAST/EiJ ENSTCUG00005013108
 protein coding gene Chr18:43470273-43485473 (-)
CBA/J ENSMUSG00210022362
 protein coding gene Chr18:44103464-44118664 (-)
DBA/2J ENSMUSG00185027812
 protein coding gene Chr18:44003660-44018859 (-)
FVB/NJ ENSMUSG00205013126
 protein coding gene Chr18:43478374-43493581 (-)
JF1/MsJ ENSUMUG00000022960
 protein coding gene Chr18:44021020-44036245 (-)
LP/J ENSMUSG00230026400
 protein coding gene Chr18:46077436-46092641 (-)
NOD/ShiLtJ ENSMUSG00190024794
 protein coding gene Chr18:43779109-43794313 (-)
NZO/HlLtJ ENSMUSG00225026807
 protein coding gene Chr18:45954541-45969742 (-)
PWK/PhJ ENSLUMG00010021174
 protein coding gene Chr18:44133171-44148437 (-)
SPRET/EiJ ENSMSPG00010012867
 protein coding gene Chr18:44291880-44306963 (-)
WSB/EiJ ENSIUOG00005009167
 protein coding gene Chr18:43699723-43715019 (-)



Homology
more
  • Human Ortholog
    CDO1, cysteine dioxygenase type 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDO1, cysteine dioxygenase type 1
  • Synonyms
    CDO-I
  • Links
    NCBI Gene ID: 1036
    UniProt: Q16878

  • Chr Location
    5q22.3; chr5:115804733-115816660 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a deletion of this gene show increased preweaning mortality, lower body weight, behavioral defects, skeletal defects, homeostatic and reproductive defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    126
  • cDNA Data
    238
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033022 Ensembl Gene Model | MGI Sequence Detail 15203 C57BL/6J ±  kb
    transcript ENSMUST00000035804 Ensembl | MGI Sequence Detail 1595 Not Applicable  
    polypeptide ENSMUSP00000046517 Ensembl | MGI Sequence Detail 200 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 246
      cDNA 240
      Primer pair 4
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33603, MGD-MRK-5037, MGI:1923528, MGI:91193
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 14
      Gene Ontology 12
      Phenotypes 11
    • Earliest
      J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
    • Latest
      J:387884 Xiao H, et al., Covariation MS uncovers a protein that controls cysteine catabolism. Nature. 2025 Nov;647(8088):268-276
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory