About   Help   FAQ
Cdo1
Gene Detail
Symbol

Name
ID
Cdo1
cysteine dioxygenase 1, cytosolic
MGI:105925
Synonyms
1300002L19Rik, Cdo, D18Ucla3
Feature Type
protein coding gene
Genetic Map
Chromosome 18
24.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr18:46713205-46728342 bp, - strand
From NCBI annotation of GRCm38

  15138 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1365  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: Cysteine dioxygenase
Gene Tree: Cdo1

Human
homologs
Human Homolog CDO1, cysteine dioxygenase type 1
NCBI Gene ID 1036
neXtProt AC  NX_Q16878
Human Chr (Location)  5q23.2; chr5:115804733-115816954 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(23) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a deletion of this gene show increased preweaning mortality, lower body weight, behavioral defects, skeletal defects, homeostatic and reproductive defects.
 
Interactions
Cdo1 interacts with 99 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process lactation, L-cysteine catabolic process, ...
Component cytosol
Function cysteine dioxygenase activity, dioxygenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (112)    Tissues (105)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
Northern blot 4
RT-PCR 5
cDNA source data(237)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(243) cDNA(239) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000033022 (Evidence)
Entrez Gene12583 (Evidence)
UniGene241056
DFCITC1572055
DoTSDT.55107842
NIA Mouse Gene IndexU038412
EC1.13.11.20
PDB2ATF, 2Q4S
Consensus CDS ProjectCCDS29234.1
International Mouse Knockout Project StatusCdo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12583 NCBI Gene Model | MGI Sequence Detail 15138 C57BL/6J ±  kb
transcript NM_033037 RefSeq | MGI Sequence Detail 1530 C57BL/6 
polypeptide P60334 UniProt | EBI | MGI Sequence Detail 200 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(3) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010300 Cysteine dioxygenase type I
InterPro IPR011051 RmlC-like cupin domain
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000005281 cysteine dioxygenase type 1
Graphical View of Protein Domain Structure
References
(Earliest) J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
(Latest) J:207223 Li W, et al., Second-sphere interactions between the C93-Y157 cross-link and the substrate-bound Fe site influence the O(2) coupling efficiency in mouse cysteine dioxygenase. Biochemistry. 2013 Dec 23;52(51):9104-19
All references(52)
Other
accession IDs
MGD-MRK-33603, MGD-MRK-5037, MGI:1923528, MGI:91193

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory