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Cdo1
Gene Detail
Symbol

Name
ID
Cdo1
cysteine dioxygenase 1, cytosolic
MGI:105925
Synonyms
1300002L19Rik, Cdo, D18Ucla3
Feature Type
protein coding gene
Genetic Map
Chromosome 18
24.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr18:46713205-46728342 bp, - strand
From Ensembl annotation of GRCm38

  15138 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1365  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CDO1
Protein SuperFamily: Cysteine dioxygenase
Gene Tree: Cdo1

Human
homologs
CDO1, cysteine dioxygenase type 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1036
neXtProt AC: NX_Q16878

Human Chr (Location): 5q23.2; chr5:115804733-115816954 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(23) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a deletion of this gene show increased preweaning mortality, lower body weight, behavioral defects, skeletal defects, homeostatic and reproductive defects.
 
Interactions
Cdo1 interacts with 99 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process lactation, L-cysteine catabolic process, ...
Component cytosol
Function cysteine dioxygenase activity, dioxygenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (112)    Tissues (105)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
Northern blot 4
RT-PCR 5
cDNA source data(237)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cdo1    NEW 
Molecular
reagents
All nucleic(243) cDNA(239) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000033022 (Evidence)
Entrez Gene 12583 (Evidence)
UniGene 241056
DFCI TC1572055
DoTS DT.55107842
NIA Mouse Gene Index U038412
EC 1.13.11.20
PDB 2ATF, 2Q4S
Consensus CDS Project CCDS29234.1
International Mouse Phenotyping Consortium Status Cdo1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033022 Ensembl Gene Model | MGI Sequence Detail 15138 C57BL/6J ±  kb
transcript ENSMUST00000035804 Ensembl | MGI Sequence Detail 1530 Not Applicable 
polypeptide ENSMUSP00000046517 Ensembl | MGI Sequence Detail 200 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(3) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010300 Cysteine dioxygenase type I
InterPro IPR011051 RmlC-like cupin domain
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000005281 cysteine dioxygenase type 1
References
(Earliest) J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
(Latest) J:217225 Blaesi EJ, et al., Spectroscopic and computational investigation of iron(III) cysteine dioxygenase: implications for the nature of the putative superoxo-Fe(III) intermediate. Biochemistry. 2014 Sep 16;53(36):5759-70
All references(51)
Other
accession IDs
MGD-MRK-33603, MGD-MRK-5037, MGI:1923528, MGI:91193

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory