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Fer Gene Detail
Summary
  • Symbol
    Fer
  • Name
    fer (fms/fps related) protein kinase
  • Synonyms
    C330004K01Rik, Fert, Fert2
  • Feature Type
    protein coding gene
  • IDs
    MGI:105917
    NCBI Gene: 14158
  • Gene Overview
    MyGene.info: FER
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:63863062-64139496 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 33.06 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1137 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105917
protein coding gene Chr17:63862073-64146519 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023972
protein coding gene Chr17:65916474-66213199 (+)
A/J MGP_AJ_G0023930
protein coding gene Chr17:63978425-64260978 (+)
AKR/J MGP_AKRJ_G0023899
protein coding gene Chr17:64836426-65119436 (+)
BALB/cJ MGP_BALBcJ_G0023931
protein coding gene Chr17:63898935-64174412 (+)
C3H/HeJ MGP_C3HHeJ_G0023695
protein coding gene Chr17:65716621-65997600 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024377
protein coding gene Chr17:68484363-68783746 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021823
protein coding gene Chr17:60099612-60368603 (+)
CAST/EiJ MGP_CASTEiJ_G0023177
protein coding gene Chr17:66042819-66354147 (+)
CBA/J MGP_CBAJ_G0023671
protein coding gene Chr17:71225631-71542158 (+)
DBA/2J MGP_DBA2J_G0023799
protein coding gene Chr17:62739752-63012911 (+)
FVB/NJ MGP_FVBNJ_G0023765
protein coding gene Chr17:62217989-62488951 (+)
LP/J MGP_LPJ_G0023881
protein coding gene Chr17:66695572-66955428 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023793
protein coding gene Chr17:71318128-71639336 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024421
protein coding gene Chr17:65317554-65592380 (+)
PWK/PhJ MGP_PWKPhJ_G0022923
protein coding gene Chr17:61982787-62269453 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022734
protein coding gene Chr17:61999384-62278352 (+)
WSB/EiJ MGP_WSBEiJ_G0023243
protein coding gene Chr17:65973740-66271302 (+)



Homology
more
  • Human Ortholog
    FER, FER tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FER, FER tyrosine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p94-Fer, PPP1R74, TYK3
  • Links
    NCBI Gene ID: 2241
    neXtProt AC: NX_P16591
    UniProt: P16591

  • Chr Location
    5q21.3; chr5:108746085-109196841 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 3 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted mutation exhibit elevated lipopolysaccharide-induced leukocyte adhesion and migration. Mutant cells also exhibit reduced phosphorylation of cortactin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000127 Ensembl Gene Model | MGI Sequence Detail 276435 C57BL/6J ±  kb
    transcript ENSMUST00000000129 Ensembl | MGI Sequence Detail 2973 Not Applicable  
    polypeptide ENSMUSP00000000129 Ensembl | MGI Sequence Detail 823 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33594, MGD-MRK-9756, MGD-MRK-9757, MGI:1924790, MGI:2147017
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 2
      Gene Ontology 14
      Phenotypes 16
    • Earliest
      J:10171 Fischman K, et al., A murine fer testis-specific transcript (ferT) encodes a truncated Fer protein. Mol Cell Biol. 1990 Jan;10(1):146-53
    • Latest
      J:293577 Navarrete FA, et al., Transient Sperm Starvation Improves the Outcome of Assisted Reproductive Technologies. Front Cell Dev Biol. 2019;7:262

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/13/2020
    MGI 6.16
    The Jackson Laboratory