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Fer Gene Detail
Summary
  • Symbol
    Fer
  • Name
    fer (fms/fps related) protein kinase
  • Synonyms
    C330004K01Rik, Fert, Fert2
  • Feature Type
    protein coding gene
  • IDs
    MGI:105917
    NCBI Gene: 14158
  • Gene Overview
    MyGene.info: FER
Location & Maps
more
  • Sequence Map
    Chr17:63896018-64139494 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      243477 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 33.06 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    FER, FER tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FER, FER tyrosine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p94-Fer, PPP1R74, TYK3
  • Links
    NCBI Gene ID: 2241
    neXtProt AC: NX_P16591

  • Chr Location
    5q21.3; chr5:108746085-109187674 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    11 phenotype references
Homozygotes for a targeted mutation exhibit elevated lipopolysaccharide-induced leukocyte adhesion and migration. Mutant cells also exhibit reduced phosphorylation of cortactin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000127 Ensembl Gene Model | MGI Sequence Detail 243477 C57BL/6J ±  kb
transcript ENSMUST00000000129 Ensembl | MGI Sequence Detail 3008 Not Applicable  
polypeptide ENSMUSP00000000129 Ensembl | MGI Sequence Detail 823 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1137 from dbSNP Build 142
  • PCR
Protein
Information
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Molecular
Reagents
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  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-33594, MGD-MRK-9756, MGD-MRK-9757, MGI:1924790, MGI:2147017
References
more
  • Summaries
    All 57
    Developmental Gene Expression 2
    Gene Ontology 14
    Phenotypes 11
  • Earliest
    J:10171 Fischman K, et al., A murine fer testis-specific transcript (ferT) encodes a truncated Fer protein. Mol Cell Biol. 1990 Jan;10(1):146-53
  • Latest
    J:224258 Sangrar W, et al., Amplified Ras-MAPK signal states correlate with accelerated EGFR internalization, cytostasis and delayed HER2 tumor onset in Fer-deficient model systems. Oncogene. 2015 Jul 30;34(31):4109-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory