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Dmc1 Gene Detail
Summary
  • Symbol
    Dmc1
  • Name
    DNA meiotic recombinase 1
  • Synonyms
    Dmc1, Dmc1h, Mei11, sgdp
  • Feature Type
    protein coding gene
  • IDs
    MGI:105393
    NCBI Gene: 13404
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79445698-79489310 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.79 cM, cytoband E
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    930 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105393
 protein coding gene Chr15:79445698-79489362 (-)
129S1/SvImJ ENSMUSG00200051794
 protein coding gene Chr15:76558285-76609221 (-)
A/J ENSMUSG00195044997
 protein coding gene Chr15:76500943-76552158 (-)
AKR/J ENSMUSG00220049049
 protein coding gene Chr15:76544344-76595557 (-)
BALB/cJ ENSMUSG00180047910
 protein coding gene Chr15:76377933-76429142 (-)
C3H/HeJ ENSMUSG00175049317
 protein coding gene Chr15:76689165-76740378 (-)
C57BL/6NJ ENSMUSG00215050762
 protein coding gene Chr15:76456086-76499746 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020018
 protein coding gene Chr15:73565073-73609677 (-)
CAST/EiJ ENSTCUG00005041712
 protein coding gene Chr15:75998920-76042799 (-)
CBA/J ENSMUSG00210040601
 protein coding gene Chr15:76464321-76515518 (-)
DBA/2J ENSMUSG00185049341
 protein coding gene Chr15:76474188-76525381 (-)
FVB/NJ ENSMUSG00205048695
 protein coding gene Chr15:76201510-76252719 (-)
JF1/MsJ ENSUMUG00000052545
 protein coding gene Chr15:76053349-76095556 (-)
LP/J ENSMUSG00230052500
 protein coding gene Chr15:79806725-79857658 (-)
NOD/ShiLtJ ENSMUSG00190048253
 protein coding gene Chr15:76484207-76535139 (-)
NZO/HlLtJ ENSMUSG00225048326
 protein coding gene Chr15:80136931-80180523 (-)
PWK/PhJ ENSLUMG00010042491
 protein coding gene Chr15:76274621-76319084 (-)
SPRET/EiJ ENSMSPG00010044886
 protein coding gene Chr15:77934970-77979266 (-)
WSB/EiJ ENSIUOG00005045184
 protein coding gene Chr15:76541288-76584884 (-)



Homology
more
  • Human Ortholog
    DMC1, DNA meiotic recombinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DMC1, DNA meiotic recombinase 1
  • Synonyms
    dJ199H16.1, DMC1H, LIM15
  • Links
    NCBI Gene ID: 11144
    UniProt: Q14565

  • Chr Location
    22q13.1; chr22:38509147-38570211 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dmc1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 4 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations are sterile with failure of homologous pairing in meiotic prophase in males and disrupted oogenesis in embryonic females with absence of germ cells in the adult ovary.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    32
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    33
  • cDNA Data
    19
  • Literature Summary
    79
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022429 Ensembl Gene Model | MGI Sequence Detail 43613 C57BL/6J ±  kb
    transcript ENSMUST00000023065 Ensembl | MGI Sequence Detail 2219 Not Applicable  
    polypeptide ENSMUSP00000023065 Ensembl | MGI Sequence Detail 340 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000006536 meiotic recombination protein DMC1/LIM15
      (term hierarchy)
    • EC
      3.6.4.-
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR016467 DNA recombination and repair protein, RecA-like
      IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
      IPR020587 DNA recombination and repair protein RecA, monomer-monomer interface
      IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
      IPR011940 Meiotic recombination protein Dmc1
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR013632 Rad51-like, C-terminal
      IPR060101 SAM-like helix-hairpin-helix tandem
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 9
      cDNA 19
      Primer pair 11
      Other 1
      Antibodies 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33063, MGI:1890405
    References
    more
    • Summaries
      All 202
      Developmental Gene Expression 79
      Diseases 2
      Gene Ontology 32
      Phenotypes 71
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory