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Dmc1 Gene Detail
Summary
  • Symbol
    Dmc1
  • Name
    DNA meiotic recombinase 1
  • Synonyms
    Dmc1, Dmc1h, Mei11, sgdp
  • Feature Type
    protein coding gene
  • IDs
    MGI:105393
    NCBI Gene: 13404
  • Gene Overview
    MyGene.info: DMC1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:79561500-79605084 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43585 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.79 cM, cytoband E
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    DMC1, DNA meiotic recombinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DMC1, DNA meiotic recombinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ199H16.1, DMC1H, LIM15
  • Links
    NCBI Gene ID: 11144
    neXtProt AC: NX_Q14565
    UniProt: Q14565

  • Chr Location
    22q13.1; chr22:38509154-38570286 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Dmc1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations are sterile with failure of homologous pairing in meiotic prophase in males and disrupted oogenesis in embryonic females with absence of germ cells in the adult ovary.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022429 Ensembl Gene Model | MGI Sequence Detail 43585 C57BL/6J ±  kb
    transcript ENSMUST00000023065 Ensembl | MGI Sequence Detail 2192 Not Applicable  
    polypeptide ENSMUSP00000023065 Ensembl | MGI Sequence Detail 340 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      169 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000006536 meiotic recombination protein DMC1/LIM15
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR013632 DNA recombination and repair protein Rad51-like, C-terminal
      IPR016467 DNA recombination and repair protein, RecA-like
      IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
      IPR020587 DNA recombination and repair protein RecA, monomer-monomer interface
      IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
      IPR011940 Meiotic recombinase Dmc1
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR033925 Rad51/DMC1/RadA
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 8
      cDNA 17
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33063, MGI:1890405
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 43
      Diseases 2
      Gene Ontology 17
      Phenotypes 50
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:254283 Endo T, et al., Periodic production of retinoic acid by meiotic and somatic cells coordinates four transitions in mouse spermatogenesis. Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10132-E10141

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory