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Dmc1
Gene Detail
 Symbol
Name
ID
Dmc1
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination
MGI:105393
Synonyms Dmc1, Dmc1h, Mei11, sgdp
Feature Type protein coding gene
Genetic Map
Chromosome 15
37.79 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr15:79561500-79605084 bp, - strand
From NCBI annotation of GRCm38

  43585 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5135  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA repair and recombination protein, Rad51 type
Gene Tree: Dmc1

Human
homologs
Human Homolog DMC1, DNA meiotic recombinase 1
NCBI Gene ID 11144
neXtProt AC  NX_Q14565
Human Synonyms  dJ199H16.1, DMC1H, LIM15
Human Chr (Location)  22q13.1; chr22:38518928-38570286 (-)  GRCh38
Alleles
and
phenotypes
All alleles(10) : Chemically induced (other)(1) Gene trapped(7) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations are sterile with failure of homologous pairing in meiotic prophase in males and disrupted oogenesis in embryonic females with absence of germ cells in the adult ovary.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cell cycle, DNA metabolic process, ...
Component chromosome, chromosome, telomeric region, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (17)    Tissues (12)    Images (13)
Theiler Stages: 20, 21, 22, 23, 24, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 10
RT-PCR 6
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(28) Genomic(8) cDNA(17) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000022429 (Evidence)
Entrez Gene13404 (Evidence)
UniGene2524
DFCITC1587671, TC1595691
DoTSDT.101719440, DT.55109403, DT.94150658
NIA Mouse Gene IndexU036408
Consensus CDS ProjectCCDS27644.1
International Mouse Knockout Project StatusDmc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13404 NCBI Gene Model | MGI Sequence Detail 43585 C57BL/6J ±  kb
transcript NM_010059 RefSeq | MGI Sequence Detail 2227 C57BL/6 
polypeptide Q61880 UniProt | EBI | MGI Sequence Detail 340 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(11) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(168 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR013632 DNA recombination and repair protein Rad51, C-terminal
InterPro IPR016467 DNA recombination and repair protein, RecA-like
InterPro IPR020587 DNA recombination/repair protein RecA, monomer-monomer interface
InterPro IPR020588 DNA recombination/repair protein RecA/RadB, ATP-binding domain
InterPro IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
InterPro IPR003583 Helix-hairpin-helix DNA-binding motif, class 1
InterPro IPR011940 Meiotic recombinase Dmc1
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000006536 meiotic recombination protein DMC1/LIM15
Graphical View of Protein Domain Structure
References (Earliest) J:32172 Sato S, et al., Expression profiles of a human gene identified as a structural homologue of meiosis-specific recA-like genes. DNA Res. 1995 Aug 31;2(4):183-6
(Latest) J:207474 Bolcun-Filas E, et al., Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathway. Science. 2014 Jan 31;343(6170):533-6
All references(90)
Other
accession IDs
MGD-MRK-33063, MGI:1890405

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory