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Dmc1
Gene Detail
Symbol

Name
ID
Dmc1
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination
MGI:105393
Synonyms
Dmc1, Dmc1h, Mei11, sgdp
Feature Type
protein coding gene
Genetic Map
Chromosome 15
37.79 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr15:79561500-79605084 bp, - strand
From Ensembl annotation of GRCm38

  43585 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5135  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DMC1
Protein SuperFamily: DNA repair and recombination protein, Rad51 type
Gene Tree: Dmc1

Human
homologs
DMC1, DNA meiotic recombinase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 11144
neXtProt AC: NX_Q14565

Human Synonyms: dJ199H16.1, DMC1H, LIM15

Human Chr (Location): 22q13.1; chr22:38509154-38570286 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (other)(1) Gene trapped(7) Radiation induced(1) Targeted(2)
Genomic Mutations involving Dmc1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted mutations are sterile with failure of homologous pairing in meiotic prophase in males and disrupted oogenesis in embryonic females with absence of germ cells in the adult ovary.
 
Phenotype Images(4)
Interactions
Dmc1 interacts with 173 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cell cycle, DNA metabolic process, ...
Component chromosome, chromosome, telomeric region, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (17)    Tissues (12)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 10
RT-PCR 6
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dmc1 ; ZFIN dmc1    NEW 
Molecular
reagents
All nucleic(28) Genomic(8) cDNA(17) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000022429 (Evidence)
Entrez Gene 13404 (Evidence)
UniGene 2524
DFCI TC1587671, TC1595691
DoTS DT.101719440, DT.55109403, DT.94150658
NIA Mouse Gene Index U036408
Consensus CDS Project CCDS27644.1
International Mouse Phenotyping Consortium Status Dmc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022429 Ensembl Gene Model | MGI Sequence Detail 43585 C57BL/6J ±  kb
transcript ENSMUST00000023065 Ensembl | MGI Sequence Detail 2192 Not Applicable 
polypeptide ENSMUSP00000023065 Ensembl | MGI Sequence Detail 340 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(11) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(168 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR013632 DNA recombination and repair protein Rad51, C-terminal
InterPro IPR016467 DNA recombination and repair protein, RecA-like
InterPro IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
InterPro IPR020587 DNA recombination and repair protein RecA, monomer-monomer interface
InterPro IPR010995 DNA repair Rad51/transcription factor NusA, alpha-helical
InterPro IPR003583 Helix-hairpin-helix DNA-binding motif, class 1
InterPro IPR011940 Meiotic recombinase Dmc1
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000006536 meiotic recombination protein DMC1/LIM15
References
(Earliest) J:32671 Sato S, et al., Characterization of a mouse recA-like gene specifically expressed in testis. DNA Res. 1995 Jun 30;2(3):147-50
(Latest) J:221418 Endo T, et al., Periodic retinoic acid-STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis. Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2347-56
All references(96)
Other
accession IDs
MGD-MRK-33063, MGI:1890405

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory