Cdkn2c
Gene Detail

Symbol Name ID

Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) MGI:105388

Synonyms

INK4c, p18, p18INK4c

Feature Type

protein coding gene

Genetic Map

Chromosome 4

51.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:109660876-109667189 bp, - strand From VEGA annotation of GRCm38   6314 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:966  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cyclin-dependent kinase inhibitor p19
Gene Tree: Cdkn2c

Human homologs

Human Homolog		CDKN2C, cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
NCBI Gene ID		1031
neXtProt AC		NX_P42773
Human Synonyms		INK4C, p18, p18-INK4C
Human Chr (Location)		1p32; chr1:51434367-51440309 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(14) : Targeted(6) Gene trapped(8)
 

Homozygotes for targeted null mutations exhibit kidney and mammary gland cortical cysts, Leydig cell hyperplasia, reduced testosterone levels, late developing thymic lymphomas and pituitary tumors, gigantism, and organomegaly.

 
Human Diseases Modeled Using Mouse Cdkn2c (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cell cycle, cell cycle arrest, ...
Component	cytoplasm, nucleus
Function	cyclin-dependent protein serine/threonine kinase inhibitor activity, protein kinase binding

External Resources: FuncBase

Expression

Literature Summary: (21 records)
Data Summary: Results (195)    Tissues (141)    Images (43)
Theiler Stages: 10, 18, 19, 22, 23, 25, 28

Assay Type	Results
RNA in situ	183
Northern blot	12

cDNA source data(62)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(64) cDNA(62) Primer pair(1) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000008484 (Evidence)
Ensembl Gene Model	ENSMUSG00000028551 (Evidence)
Entrez Gene	12580 (Evidence)
UniGene	1912
DFCI	TC1579289, TC1596499, TC1603699
DoTS	DT.101379167, DT.101735011, DT.110830824, DT.491252
NIA Mouse Gene Index	U025375
Consensus CDS Project	CCDS18467.1
International Mouse Knockout Project Status	Cdkn2c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008484	VEGA Gene Model | MGI Sequence Detail	6314	C57BL/6J
transcript	OTTMUST00000019256	VEGA | MGI Sequence Detail	2471	Not Applicable
polypeptide	OTTMUSP00000008831	VEGA | MGI Sequence Detail	168	Not Applicable

All sequences(33) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
Protein Ontology	PR:000005278	cyclin-dependent kinase 4 inhibitor C

References

(Earliest) J:24521 Hirai H, et al., Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol Cell Biol. 1995 May;15(5):2672-81
(Latest) J:193430 Rossi L, et al., Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice. Cell Stem Cell. 2012 Sep 7;11(3):302-17
All references(101)

Other accession IDs

MGD-MRK-33058, MGI:2140654