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Cdkn2c
Gene Detail
Symbol

Name
ID
Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
MGI:105388
Synonyms
INK4c, p18, p18INK4c
Feature Type
protein coding gene
Genetic Map
Chromosome 4
51.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:109660876-109667189 bp, - strand
From VEGA annotation of GRCm38

  6314 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:966  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDKN2C
Protein SuperFamily: cyclin-dependent kinase inhibitor p19
Gene Tree: Cdkn2c

Human
homologs
CDKN2C, cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1031
neXtProt AC: NX_P42773

Human Synonyms: INK4C, p18, p18-INK4C

Human Chr (Location): 1p32; chr1:50968695-50974637 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(8) Targeted(7)
Genomic Mutations involving Cdkn2c (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit kidney and mammary gland cortical cysts, Leydig cell hyperplasia, reduced testosterone levels, late developing thymic lymphomas and pituitary tumors, gigantism, and organomegaly.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Cdkn2c interacts with 56 markers (Mir7-1, Mir19a, Mir34b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell cycle, cell cycle arrest, ...
Component cytoplasm, nucleus
Function cyclin-dependent protein serine/threonine kinase inhibitor activity, protein kinase binding
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (197)    Tissues (142)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 183
Northern blot 12
RT-PCR 2
cDNA source data(41)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cdkn2c    NEW 
Molecular
reagents
All nucleic(44) cDNA(41) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000008484 (Evidence)
Ensembl Gene Model ENSMUSG00000028551 (Evidence)
Entrez Gene 12580 (Evidence)
UniGene 1912
DFCI TC1579289, TC1596499, TC1603699
DoTS DT.110830824, DT.101735011, DT.101379167, DT.101379165, DT.491252
NIA Mouse Gene Index U025375
Consensus CDS Project CCDS18467.1
International Mouse Phenotyping Consortium Status Cdkn2c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008484 VEGA Gene Model | MGI Sequence Detail 6314 C57BL/6J ±  kb
transcript OTTMUST00000019256 VEGA | MGI Sequence Detail 2471 Not Applicable 
polypeptide OTTMUSP00000008831 VEGA | MGI Sequence Detail 168 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000005278 cyclin-dependent kinase 4 inhibitor C
References
(Earliest) J:24521 Hirai H, et al., Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol Cell Biol. 1995 May;15(5):2672-81
(Latest) J:217589 Kawakami E, et al., The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators. Mech Dev. 2015 Feb;135:31-42
All references(111)
Other
accession IDs
MGD-MRK-33058, MGI:2140654

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory