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Cdkn2d Gene Detail
Summary
  • Symbol
    Cdkn2d
  • Name
    cyclin dependent kinase inhibitor 2D
  • Synonyms
    INK4d, INK4d, p19, p19INK4d
  • Feature Type
    protein coding gene
  • IDs
    MGI:105387
    NCBI Gene: 12581
  • Gene Overview
    MyGene.info: CDKN2D
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:21288459-21291402 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2944 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.76 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CDKN2D, cyclin dependent kinase inhibitor 2D
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CDKN2D, cyclin dependent kinase inhibitor 2D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    INK4D, p19, p19-INK4D
  • Links
    NCBI Gene ID: 1032
    neXtProt AC: NX_P55273
    UniProt: P55273

  • Chr Location
    19p13.2; chr19:10566462-10568979 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 4 genetic backgrounds
    44 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Both female and male homozygous null mice are fertile in spite of testicular atrophy and increased male germ cell apoptosis due to delayed meiosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12581 NCBI Gene Model | MGI Sequence Detail 2944 C57BL/6J ±  kb
    transcript NM_009878 RefSeq | MGI Sequence Detail 1271 C57BL/6  
    polypeptide Q60773 UniProt | EBI | MGI Sequence Detail 166 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      12 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 57
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33057
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 29
      Gene Ontology 4
      Phenotypes 21
    • Earliest
      J:24520 Chan FK, et al., Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol Cell Biol. 1995 May;15(5):2682-8
    • Latest
      J:259463 Gamell C, et al., Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer. Sci Signal. 2017 Jan 10;10(461):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory