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Cdkn2d Gene Detail
Summary
  • Symbol
    Cdkn2d
  • Name
    cyclin dependent kinase inhibitor 2D
  • Synonyms
    INK4d, INK4d, p19, p19INK4d
  • Feature Type
    protein coding gene
  • IDs
    MGI:105387
    NCBI Gene: 12581
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21199759-21202553 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105387
 protein coding gene Chr9:21199706-21202703 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034448
 protein coding gene Chr9:18488596-18491340 (-)
A/J MGP_AJ_G0034426
 protein coding gene Chr9:18176313-18179059 (-)
AKR/J MGP_AKRJ_G0034353
 protein coding gene Chr9:18511068-18513814 (-)
BALB/cJ MGP_BALBcJ_G0034417
 protein coding gene Chr9:18066935-18069681 (-)
C3H/HeJ MGP_C3HHeJ_G0034129
 protein coding gene Chr9:18815010-18818164 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034938
 protein coding gene Chr9:19232816-19235562 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031868
 protein coding gene Chr9:17299580-17302511 (-)
CAST/EiJ MGP_CASTEiJ_G0033452
 protein coding gene Chr9:18641332-18644119 (-)
CBA/J MGP_CBAJ_G0034102
 protein coding gene Chr9:19960806-19963552 (-)
DBA/2J MGP_DBA2J_G0034261
 protein coding gene Chr9:18149205-18151944 (-)
FVB/NJ MGP_FVBNJ_G0034204
 protein coding gene Chr9:17676995-17679768 (-)
LP/J MGP_LPJ_G0034346
 protein coding gene Chr9:18658266-18661030 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034247
 protein coding gene Chr9:21558992-21561764 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034958
 protein coding gene Chr9:18467779-18470525 (-)
PWK/PhJ MGP_PWKPhJ_G0033158
 protein coding gene Chr9:18130781-18133583 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032992
 protein coding gene Chr9:18514552-18518469 (-)
WSB/EiJ MGP_WSBEiJ_G0033567
 protein coding gene Chr9:18189199-18191943 (-)



Homology
more
  • Human Ortholog
    CDKN2D, cyclin dependent kinase inhibitor 2D
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDKN2D, cyclin dependent kinase inhibitor 2D
  • Synonyms
    INK4D, p19, p19-INK4D
  • Links
    NCBI Gene ID: 1032
    neXtProt AC: NX_P55273
    UniProt: P55273

  • Chr Location
    19p13.2; chr19:10566460-10569059 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 4 genetic backgrounds
    44 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Both female and male homozygous null mice are fertile in spite of testicular atrophy and increased male germ cell apoptosis due to delayed meiosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    63
  • cDNA Data
    58
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12581 NCBI Gene Model | MGI Sequence Detail 2795 C57BL/6J ±  kb
    transcript NM_001409666 RefSeq | MGI Sequence Detail 1245 C57BL/6  
    polypeptide Q60773 UniProt | EBI | MGI Sequence Detail 166 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 58
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33057
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 34
      Gene Ontology 5
      Phenotypes 24
    • Earliest
      J:24520 Chan FK, et al., Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol Cell Biol. 1995 May;15(5):2682-8
    • Latest
      J:321171 Safwan-Zaiter H, et al., Dynamic Spatiotemporal Expression Pattern of the Senescence-Associated Factor p16Ink4a in Development and Aging. Cells. 2022 Feb 4;11(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory