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Cdkn2d Gene Detail
Summary
  • Symbol
    Cdkn2d
  • Name
    cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
  • Synonyms
    INK4d, INK4d, p19, p19INK4d
  • Feature Type
    protein coding gene
  • IDs
    MGI:105387
    NCBI Gene: 12581
  • Gene Overview
    MyGene.info: CDKN2D
Location & Maps
more
  • Sequence Map
    Chr9:21288463-21291209 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2747 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.76 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CDKN2D, cyclin dependent kinase inhibitor 2D
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CDKN2D, cyclin dependent kinase inhibitor 2D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    INK4D, p19, p19-INK4D
  • Links
    NCBI Gene ID: 1032
    neXtProt AC: NX_P55273

  • Chr Location
    19p13.2; chr19:10566462-10568979 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 4 genetic backgrounds
    44 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Gene trapped
    7
  • Targeted
    6
  • Incidental Mutations
Both female and male homozygous null mice are fertile in spite of testicular atrophy and increased male germ cell apoptosis due to delayed meiosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000096472 Ensembl Gene Model | MGI Sequence Detail 2747 C57BL/6J ±  kb
transcript ENSMUST00000086374 Ensembl | MGI Sequence Detail 1271 Not Applicable  
polypeptide ENSMUSP00000083561 Ensembl | MGI Sequence Detail 166 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    12 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    cDNA 57
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33057
References
more
  • Summaries
    All 70
    Developmental Gene Expression 29
    Gene Ontology 4
    Phenotypes 20
  • Earliest
    J:24520 Chan FK, et al., Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol Cell Biol. 1995 May;15(5):2682-8
  • Latest
    J:230833 Mardaryev AN, et al., Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. J Cell Biol. 2016 Jan 4;212(1):77-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory