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Cdkn2d
Gene Detail
Symbol

Name
ID
Cdkn2d
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
MGI:105387
Synonyms
INK4d, INK4d, p19, p19INK4d
Feature Type
protein coding gene
Genetic Map
Chromosome 9
7.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:21288463-21291209 bp, - strand
From Ensembl annotation of GRCm38

  2747 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36081  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cyclin-dependent kinase inhibitor p19
Gene Tree: Cdkn2d

Human
homologs
Human Homolog CDKN2D, cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
NCBI Gene ID 1032
neXtProt AC  NX_P55273
Human Synonyms  INK4D, p19, p19-INK4D
Human Chr (Location)  19p13; chr19:10566462-10568979 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix )
 
Both female and male homozygous null mice are fertile in spite of testicular atrophy and increased male germ cell apoptosis due to delayed meiosis.
 
Interactions
Cdkn2d interacts with 52 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process autophagic cell death, cell cycle, ...
Component cytoplasm, nucleus
Function cyclin-dependent protein serine/threonine kinase inhibitor activity, protein kinase binding
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (125)    Tissues (54)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 111
Northern blot 12
RT-PCR 2
cDNA source data(57)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(59) cDNA(57) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000096472 (Evidence)
Entrez Gene12581 (Evidence)
UniGene29020
DFCITC1576924
DoTSDT.101248203, DT.99851789, DT.492861, DT.110607984
NIA Mouse Gene IndexU030576, U374296
PDB1BLX, 1AP7
Consensus CDS ProjectCCDS22901.1
International Mouse Knockout Project StatusCdkn2d
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000096472 Ensembl Gene Model | MGI Sequence Detail 2747 C57BL/6J ±  kb
transcript ENSMUST00000086374 Ensembl | MGI Sequence Detail 1271 Not Applicable 
polypeptide ENSMUSP00000083561 Ensembl | MGI Sequence Detail 166 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000005279 cyclin-dependent kinase 4 inhibitor D
References
(Earliest) J:24520 Chan FK, et al., Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol Cell Biol. 1995 May;15(5):2682-8
(Latest) J:205284 Storer M, et al., Senescence is a developmental mechanism that contributes to embryonic growth and patterning. Cell. 2013 Nov 21;155(5):1119-30
All references(71)
Other
accession IDs
MGD-MRK-33057

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory