About   Help   FAQ
Cdkn2d
Gene Detail
 Symbol
Name
ID
Cdkn2d
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
MGI:105387
Synonyms INK4d, INK4d, p19, p19INK4d
Feature Type protein coding gene
Genetic Map
Chromosome 9
7.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:21288463-21291209 bp, - strand
From NCBI annotation of GRCm38

  2747 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36081  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cyclin-dependent kinase inhibitor p19
Gene Tree: Cdkn2d

Human
homologs
Human Homolog CDKN2D, cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
NCBI Gene ID 1032
neXtProt AC  NX_P55273
Human Synonyms  INK4D, p19, p19-INK4D
Human Chr (Location)  19p13; chr19:10566462-10568979 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix )
 
Both female and male homozygous null mice are fertile in spite of testicular atrophy and increased male germ cell apoptosis due to delayed meiosis.
 
Interactions
Cdkn2d interacts with 52 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process autophagic cell death, cell cycle, ...
Component cytoplasm, nucleus
Function cyclin-dependent protein serine/threonine kinase inhibitor activity, protein kinase binding
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (125)    Tissues (54)    Images (31)
Theiler Stages: 10, 17, 18, 19, 23, 25, 28
Assay TypeResults
RNA in situ 111
Northern blot 12
RT-PCR 2
cDNA source data(57)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(59) cDNA(57) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000096472 (Evidence)
Entrez Gene12581 (Evidence)
UniGene29020
DFCITC1576924
DoTSDT.101248203, DT.110607984, DT.492861, DT.99851789
NIA Mouse Gene IndexU030576, U374296
PDB1BLX, 1AP7
Consensus CDS ProjectCCDS22901.1
International Mouse Knockout Project StatusCdkn2d
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12581 NCBI Gene Model | MGI Sequence Detail 2747 C57BL/6J ±  kb
transcript NM_009878 RefSeq | MGI Sequence Detail 1271 C57BL/6 
polypeptide Q60773 UniProt | EBI | MGI Sequence Detail 166 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000005279 cyclin-dependent kinase 4 inhibitor D
Graphical View of Protein Domain Structure
References (Earliest) J:24520 Chan FK, et al., Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol Cell Biol. 1995 May;15(5):2682-8
(Latest) J:201041 Park DS, et al., Pocket proteins critically regulate cell cycle exit of the trabecular myocardium and the ventricular conduction system. Biol Open. 2013;2:968-978
All references(70)
Other
accession IDs
MGD-MRK-33057

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory