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Il18r1
Gene Detail
Symbol

Name
ID
Il18r1
interleukin 18 receptor 1
MGI:105383
Synonyms
Il18ralpha, Il1rrp
Feature Type
protein coding gene
Genetic Map
Chromosome 1
19.27 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:40465552-40500853 bp, + strand
From VEGA annotation of GRCm38

  35302 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2861  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog

HCOP human homology predictions: IL18R1
Gene Tree: Il18r1

Human
homologs
IL18R1, interleukin 18 receptor 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8809
neXtProt AC: NX_Q13478

Human Synonyms: CD218a, CDw218a, IL18RA, IL-1Rrp, IL1RRP

Human Chr (Location): 2q12; chr2:102356283-102398777 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene exhibit impaire Th1 cell development and defective NK cell physiology.
 
Interactions
Il18r1 interacts with 263 markers (Mir7-1, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process interleukin-18-mediated signaling pathway, natural killer cell activation, ...
Component integral component of membrane, membrane
Function interleukin-18 receptor activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (13)    Tissues (4)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
RT-PCR 9
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000050472 (Evidence)
Ensembl Gene Model ENSMUSG00000026070 (Evidence)
Entrez Gene 16182 (Evidence)
UniGene 253664
DFCI TC1595210, TC1592748, TC1621508, TC1696536
DoTS DT.101716330, DT.91424834, DT.99846250, DT.91382817, DT.91332248
NIA Mouse Gene Index U000200
Consensus CDS Project CCDS35549.1, CCDS48247.1
International Mouse Phenotyping Consortium Status Il18r1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050472 VEGA Gene Model | MGI Sequence Detail 35302 C57BL/6J ±  kb
transcript OTTMUST00000128058 VEGA | MGI Sequence Detail 2850 Not Applicable 
polypeptide OTTMUSP00000068958 VEGA | MGI Sequence Detail 537 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(22) UniProt(4)
Polymorphisms
SNPs within 2kb(291 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR015621 Interleukin-1 receptor family
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Protein Ontology PR:000001377 interleukin-18 receptor 1
References
(Earliest) J:31466 Parnet P, et al., IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. J Biol Chem. 1996 Feb 23;271(8):3967-70
(Latest) J:218021 Yano T, et al., The pathological role of IL-18Ralpha in renal ischemia/reperfusion injury. Lab Invest. 2015 Jan;95(1):78-91
All references(79)
Other
accession IDs
MGD-MRK-33052

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory