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Il18r1
Gene Detail
Symbol

Name
ID
Il18r1
interleukin 18 receptor 1
MGI:105383
Synonyms
Il18ralpha, Il1rrp
Feature Type
protein coding gene
Genetic Map
Chromosome 1
19.27 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:40465552-40500853 bp, + strand
From VEGA annotation of GRCm38

  35302 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2861  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog

Gene Tree: Il18r1

Human
homologs
Human Homolog   IL18R1, interleukin 18 receptor 1
NCBI Gene ID 8809
neXtProt AC  NX_Q13478
Human Synonyms  CD218a, CDw218a, IL18RA, IL-1Rrp, IL1RRP
Human Chr (Location)  2q12; chr2:102356283-102398775 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene exhibit impaire Th1 cell development and defective NK cell physiology.
 
Interactions
Il18r1 interacts with 264 markers (Mir7-1, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process interleukin-18-mediated signaling pathway, natural killer cell activation, ...
Component integral component of membrane, membrane
Function interleukin-18 receptor activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (13)    Tissues (4)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
RT-PCR 9
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000050472 (Evidence)
Ensembl Gene ModelENSMUSG00000026070 (Evidence)
Entrez Gene16182 (Evidence)
UniGene253664
DFCITC1696536, TC1621508, TC1595210, TC1592748
DoTSDT.91382817, DT.91332248, DT.101716330, DT.99846250, DT.91424834
NIA Mouse Gene IndexU000200
Consensus CDS ProjectCCDS35549.1, CCDS48247.1
International Mouse Knockout Project StatusIl18r1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050472 VEGA Gene Model | MGI Sequence Detail 35302 C57BL/6J ±  kb
transcript OTTMUST00000128058 VEGA | MGI Sequence Detail 2850 Not Applicable 
polypeptide OTTMUSP00000068958 VEGA | MGI Sequence Detail 537 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(22) UniProt(4)
Polymorphisms
SNPs within 2kb(291 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR015621 Interleukin-1 receptor family
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Protein Ontology PR:000001377 interleukin-18 receptor 1
References
(Earliest) J:31466 Parnet P, et al., IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. J Biol Chem. 1996 Feb 23;271(8):3967-70
(Latest) J:217693 Scheeren FA, et al., A cell-intrinsic role for TLR2-MYD88 in intestinal and breast epithelia and oncogenesis. Nat Cell Biol. 2014 Dec;16(12):1238-48
All references(79)
Other
accession IDs
MGD-MRK-33052

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory