Rpsa
Gene Detail

Symbol Name ID

Rpsa ribosomal protein SA MGI:105381

Synonyms

67lr, Lamr, Lamr1, Lamrl1, P40-3, P40-8

Feature Type

protein coding gene

Genetic Map

Chromosome 9

71.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:120127766-120132369 bp, + strand From NCBI annotation of GRCm38   4604 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rpsa

Human homologs

Human Homolog		RPSA, ribosomal protein SA
NCBI Gene ID		3921
neXtProt AC		NX_P08865
Human Synonyms		37LRP, 67LR, LAMBR, lamR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, p40, SA
Human Chr (Location)		3p22.2; chr3:39448204-39454033 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RPSA

Alleles and phenotypes

All alleles(57) : Targeted(5) Gene trapped(51) Spontaneous(1)
 

Spontaneous mutants show right ventricular cardiomyocyte degeneration and higher susceptibility to arrhythmia. Homozygous null mice fail to develop past E3.5; heterozygotes show craniofacial defects, low mean corpuscular hemoglobin concentration and reduced insulin content in pancreatic islet cells.

 
Human Diseases Modeled Using Mouse Rpsa (2)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	cell-cell adhesion, endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ...
Component	90S preribosome, basement membrane, ...
Function	laminin binding, ribosome binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (82)    Tissues (64)    Images (9)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	36
RT-PCR	46

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(37) cDNA(36) Primer pair(1)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000032518 (Evidence)
Entrez Gene	16785 (Evidence)
DFCI	TC1573634, TC1594809
DoTS	DT.101293411, DT.110590034, DT.55180364, DT.94290572, DT.94290636, DT.94290644, DT.94305026, DT.97341827, DT.97341853, DT.97384533
Consensus CDS Project	CCDS23623.1
International Mouse Knockout Project Status	Rpsa

Sequences

Length	Strain/Species
genomic	16785	NCBI Gene Model | MGI Sequence Detail	4604	C57BL/6J
transcript	NM_011029	RefSeq | MGI Sequence Detail	1861	C57BL/6
polypeptide	P14206	UniProt | EBI | MGI Sequence Detail	295	Not Applicable

All sequences(81) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(3 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001865	Ribosomal protein S2
InterPro	IPR018130	Ribosomal protein S2, conserved site
InterPro	IPR005707	Ribosomal protein S2, eukaryotic/archaeal
InterPro	IPR023591	Ribosomal protein S2, flavodoxin-like domain
Protein Ontology	PR:000014293	40S ribosomal protein SA

Graphical View of Protein Domain Structure

References

(Earliest) J:9131 Makrides S, et al., Nucleotide sequence for a major messenger RNA for a 40 kilodalton polypeptide that is under translational control in mouse tumor cells. Nucleic Acids Res. 1988 Mar 25;16(5):2349
(Latest) J:170332 Byun EH, et al., Green tea polyphenol epigallocatechin-3-gallate inhibits TLR2 signaling induced by peptidoglycan through the polyphenol sensing molecule 67-kDa laminin receptor. FEBS Lett. 2011 Mar 9;585(5):814-20
All references(62)

Other accession IDs

MGD-MRK-11746, MGD-MRK-13103, MGD-MRK-16686, MGD-MRK-33050, MGI:2144924, MGI:891974, MGI:97457, MGI:99891