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Rpsa Gene Detail
Summary
  • Symbol
    Rpsa
  • Name
    ribosomal protein SA
  • Synonyms
    67lr, Lamr, Lamr1, Lamrl1, P40-3, P40-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:105381
    NCBI Gene: 16785
  • Gene Overview
    MyGene.info: RPSA
Location & Maps
more
  • Sequence Map
    Chr9:120127766-120132369 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4604 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RPSA, ribosomal protein SA
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RPSA, ribosomal protein SA
    Orthology source: HGNC, HomoloGene
  • Synonyms
    37LRP, 67LR, ICAS, LAMBR, lamR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, p40, SA
  • Links
    NCBI Gene ID: 3921
    neXtProt AC: NX_P08865

  • Chr Location
    3p22.2; chr3:39406689-39412542 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68249
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: RPSA
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Rpsa mouse models; 1 with human RPSA associations

Human Disease Mouse Models
       Arrhythmogenic Right Ventricular Dysplasia, Familial, 5; ARVD5   OMIM: 604400 View 1 model
       Asplenia, Isolated Congenital; ICAS   OMIM: 271400
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    57
  • Gene trapped
    51
  • Spontaneous
    1
  • Targeted
    5
  • Incidental Mutations
Spontaneous mutants show right ventricular cardiomyocyte degeneration and higher susceptibility to arrhythmia. Homozygous null mice fail to develop past E3.5; heterozygotes show craniofacial defects, low mean corpuscular hemoglobin concentration and reduced insulin content in pancreatic islet cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16785 NCBI Gene Model | MGI Sequence Detail 4604 C57BL/6J ±  kb
transcript NM_011029 RefSeq | MGI Sequence Detail 1861 C57BL/6  
polypeptide P14206 UniProt | EBI | MGI Sequence Detail 295 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    107 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR027504 40S ribosomal protein SA
    IPR032281 40S ribosomal protein SA, C-terminal domain
    IPR001865 Ribosomal protein S2
    IPR018130 Ribosomal protein S2, conserved site
    IPR027498 Ribosomal protein S2, eukaryotic
    IPR005707 Ribosomal protein S2, eukaryotic/archaeal
    IPR023591 Ribosomal protein S2, flavodoxin-like domain
Molecular
Reagents
less
  • All nucleic 37
    cDNA 36
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-11746, MGD-MRK-13103, MGD-MRK-16686, MGD-MRK-33050, MGI:2144924, MGI:891974, MGI:97457, MGI:99891
References
more
  • Summaries
    All 60
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:9131 Makrides S, et al., Nucleotide sequence for a major messenger RNA for a 40 kilodalton polypeptide that is under translational control in mouse tumor cells. Nucleic Acids Res. 1988 Mar 25;16(5):2349
  • Latest
    J:222425 Harada M, et al., Tissue-specific roles of FGF signaling in external genitalia development. Dev Dyn. 2015 Jun;244(6):759-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory