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Rpsa
Gene Detail
Symbol

Name
ID
Rpsa
ribosomal protein SA
MGI:105381
Synonyms
67lr, Lamr, Lamr1, Lamrl1, P40-3, P40-8
Feature Type
protein coding gene
Genetic Map
Chromosome 9
71.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:120127766-120132369 bp, + strand
From NCBI annotation of GRCm38

  4604 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rpsa

Human
homologs
Human Homolog RPSA, ribosomal protein SA
NCBI Gene ID 3921
neXtProt AC  NX_P08865
Human Synonyms  37LRP, 67LR, ICAS, LAMBR, lamR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, p40, SA
Human Chr (Location)  3p22.2; chr3:39406713-39412542 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RPSA
Mutations,
alleles, and
phenotypes
All mutations/alleles(57) : Gene trapped(51) Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Spontaneous mutants show right ventricular cardiomyocyte degeneration and higher susceptibility to arrhythmia. Homozygous null mice fail to develop past E3.5; heterozygotes show craniofacial defects, low mean corpuscular hemoglobin concentration and reduced insulin content in pancreatic islet cells.
 
Human Diseases Modeled Using Mouse Rpsa (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Rpsa interacts with 118 markers (Mir10a, Mir10b, Mir15a, ...)
Expression
Literature Summary: (12 records)
Data Summary: Results (82)    Tissues (65)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 36
RT-PCR 46
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(36) Primer pair(1)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000032518 (Evidence)
Entrez Gene16785 (Evidence)
DFCITC1573634, TC1594809
DoTSDT.101293411, DT.110590034, DT.55180364, DT.94290572, DT.94290636, DT.94290644, DT.94305026, DT.97341827, DT.97341853, DT.97384533
Consensus CDS ProjectCCDS23623.1
International Mouse Knockout Project StatusRpsa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16785 NCBI Gene Model | MGI Sequence Detail 4604 C57BL/6J ±  kb
transcript NM_011029 RefSeq | MGI Sequence Detail 1861 C57BL/6 
polypeptide P14206 UniProt | EBI | MGI Sequence Detail 295 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027504 40S ribosomal protein SA
InterPro IPR001865 Ribosomal protein S2
InterPro IPR018130 Ribosomal protein S2, conserved site
InterPro IPR027498 Ribosomal protein S2, eukaryotic
InterPro IPR005707 Ribosomal protein S2, eukaryotic/archaeal
InterPro IPR023591 Ribosomal protein S2, flavodoxin-like domain
Protein Ontology PR:000014293 40S ribosomal protein SA
Graphical View of Protein Domain Structure
References
(Earliest) J:9131 Makrides S, et al., Nucleotide sequence for a major messenger RNA for a 40 kilodalton polypeptide that is under translational control in mouse tumor cells. Nucleic Acids Res. 1988 Mar 25;16(5):2349
(Latest) J:199588 Luo XJ, et al., GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea. Hum Mol Genet. 2013 Sep 15;22(18):3609-23
All references(64)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11746, MGD-MRK-13103, MGD-MRK-16686, MGD-MRK-33050, MGI:2144924, MGI:891974, MGI:97457, MGI:99891

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory