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Rpsa Gene Detail
Summary
  • Symbol
    Rpsa
  • Name
    ribosomal protein SA
  • Synonyms
    67lr, Lamr, Lamr1, Lamrl1, P40-3, P40-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:105381
    NCBI Gene: 16785
  • Gene Overview
    MyGene.info: RPSA
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:120127766-120132369 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4604 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 71.41 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RPSA, ribosomal protein SA
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RPSA, ribosomal protein SA
    Orthology source: HomoloGene, HGNC
  • Synonyms
    37LRP, 67LR, ICAS, LAMBR, lamR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, p40, SA
  • Links
    NCBI Gene ID: 3921
    neXtProt AC: NX_P08865
    UniProt: P08865

  • Chr Location
    3p22.1; chr3:39406689-39412542 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68249
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RPSA
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Rpsa mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Spontaneous mutants show right ventricular cardiomyocyte degeneration and higher susceptibility to arrhythmia. Homozygous null mice fail to develop past E3.5; heterozygotes show craniofacial defects, low mean corpuscular hemoglobin concentration and reduced insulin content in pancreatic islet cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16785 NCBI Gene Model | MGI Sequence Detail 4604 C57BL/6J ±  kb
    transcript NM_011029 RefSeq | MGI Sequence Detail 1861 C57BL/6  
    polypeptide P14206 UniProt | EBI | MGI Sequence Detail 295 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      107 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR027504 40S ribosomal protein SA
      IPR032281 40S ribosomal protein SA, C-terminal domain
      IPR001865 Ribosomal protein S2
      IPR018130 Ribosomal protein S2, conserved site
      IPR027498 Ribosomal protein S2, eukaryotic
      IPR005707 Ribosomal protein S2, eukaryotic/archaeal
      IPR023591 Ribosomal protein S2, flavodoxin-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 36
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11746, MGD-MRK-13103, MGD-MRK-16686, MGD-MRK-33050, MGI:2144924, MGI:891974, MGI:97457, MGI:99891
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 13
      Diseases 2
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:9131 Makrides S, et al., Nucleotide sequence for a major messenger RNA for a 40 kilodalton polypeptide that is under translational control in mouse tumor cells. Nucleic Acids Res. 1988 Mar 25;16(5):2349
    • Latest
      J:222425 Harada M, et al., Tissue-specific roles of FGF signaling in external genitalia development. Dev Dyn. 2015 Jun;244(6):759-73

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory