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Rpsa Gene Detail
Summary
  • Symbol
    Rpsa
  • Name
    ribosomal protein SA
  • Synonyms
    67lr, Lamr, Lamr1, Lamrl1, P40-3, P40-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:105381
    NCBI Gene: 16785
  • Gene Overview
    MyGene.info: RPSA
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:120127766-120132369 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 71.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105381
protein coding gene Chr9:120127689-120132369 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035432
protein coding gene Chr9:122951594-122960003 (+)
A/J MGP_AJ_G0035413
protein coding gene Chr9:118345139-118349742 (+)
AKR/J MGP_AKRJ_G0035346
protein coding gene Chr9:121445655-121454611 (+)
BALB/cJ MGP_BALBcJ_G0035409
protein coding gene Chr9:118241651-118246254 (+)
C3H/HeJ MGP_C3HHeJ_G0035117
protein coding gene Chr9:121925817-121930420 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035932
protein coding gene Chr9:126315386-126321404 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032814
protein coding gene Chr9:115546649-115551617 (+)
CAST/EiJ MGP_CASTEiJ_G0034421
protein coding gene Chr9:121931295-121936097 (+)
CBA/J MGP_CBAJ_G0035084
protein coding gene Chr9:131032242-131037174 (+)
DBA/2J MGP_DBA2J_G0035243
protein coding gene Chr9:117795029-117800148 (+)
FVB/NJ MGP_FVBNJ_G0035190
protein coding gene Chr9:116683700-116690395 (+)
LP/J MGP_LPJ_G0035322
protein coding gene Chr9:123286403-123291033 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035231
protein coding gene Chr9:131975210-131980760 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035951
protein coding gene Chr9:121839721-121855304 (+)
PWK/PhJ MGP_PWKPhJ_G0034126
protein coding gene Chr9:118235584-118242451 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033962
protein coding gene Chr9:121941345-121947012 (+)
WSB/EiJ MGP_WSBEiJ_G0034541
protein coding gene Chr9:121726821-121736002 (+)



Homology
more
  • Human Ortholog
    RPSA, ribosomal protein SA
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RPSA, ribosomal protein SA
    Orthology source: HomoloGene, HGNC
  • Synonyms
    37LRP, 67LR, ICAS, LAMBR, lamR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, p40, SA
  • Links
    NCBI Gene ID: 3921
    neXtProt AC: NX_P08865
    UniProt: P08865

  • Chr Location
    3p22.1; chr3:39406689-39412542 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68249
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RPSA
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Rpsa mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Spontaneous mutants show right ventricular cardiomyocyte degeneration and higher susceptibility to arrhythmia. Homozygous null mice fail to develop past E3.5; heterozygotes show craniofacial defects, low mean corpuscular hemoglobin concentration and reduced insulin content in pancreatic islet cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16785 NCBI Gene Model | MGI Sequence Detail 4604 C57BL/6J ±  kb
    transcript NM_011029 RefSeq | MGI Sequence Detail 1861 C57BL/6  
    polypeptide P14206 UniProt | EBI | MGI Sequence Detail 295 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR027504 40S ribosomal protein SA
      IPR032281 40S ribosomal protein SA, C-terminal domain
      IPR001865 Ribosomal protein S2
      IPR018130 Ribosomal protein S2, conserved site
      IPR027498 Ribosomal protein S2, eukaryotic
      IPR005707 Ribosomal protein S2, eukaryotic/archaeal
      IPR023591 Ribosomal protein S2, flavodoxin-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 37
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11746, MGD-MRK-13103, MGD-MRK-16686, MGD-MRK-33050, MGI:2144924, MGI:891974, MGI:97457, MGI:99891
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 13
      Diseases 2
      Gene Ontology 10
      Phenotypes 9
    • Earliest
      J:9131 Makrides S, et al., Nucleotide sequence for a major messenger RNA for a 40 kilodalton polypeptide that is under translational control in mouse tumor cells. Nucleic Acids Res. 1988 Mar 25;16(5):2349
    • Latest
      J:222425 Harada M, et al., Tissue-specific roles of FGF signaling in external genitalia development. Dev Dyn. 2015 Jun;244(6):759-73

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory