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Mcm2 Gene Detail
Summary
  • Symbol
    Mcm2
  • Name
    minichromosome maintenance complex component 2
  • Synonyms
    BM28, CDCL1, Mcmd2, mKIAA0030
  • Feature Type
    protein coding gene
  • IDs
    MGI:105380
    NCBI Gene: 17216
  • Gene Overview
    MyGene.info: MCM2
Location & Maps
more
  • Sequence Map
    Chr6:88883474-88898780 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15307 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MCM2, minichromosome maintenance complex component 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MCM2, minichromosome maintenance complex component 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BM28, CCNL1, cdc19, CDCL1, D3S3194, MITOTIN
  • Links
    NCBI Gene ID: 4171
    neXtProt AC: NX_P49736

  • Chr Location
    3q21; chr3:127598357-127622436 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    35
  • Gene trapped
    31
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Mcm2
  • Incidental Mutations
Mice homozygous for non functional alleles at this locus die prematurely. There is an increased tumor incidence and abnormalities in a variety of systems in mice as they become moribund.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000057511 VEGA Gene Model | MGI Sequence Detail 15307 C57BL/6J ±  kb
transcript OTTMUST00000141420 VEGA | MGI Sequence Detail 3371 Not Applicable  
polypeptide OTTMUSP00000073920 VEGA | MGI Sequence Detail 904 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    89 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000010242 DNA replication licensing factor MCM2
  • EC
  • InterPro Domains
    IPR008045 DNA replication licensing factor Mcm2
    IPR001208 MCM domain
    IPR027925 MCM N-terminal domain
    IPR018525 Mini-chromosome maintenance, conserved site
    IPR031327 Mini-chromosome maintenance protein
    IPR012340 Nucleic acid-binding, OB-fold
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-33049, MGI:2141373, MGI:2144533
References
more
  • Summaries
    All 59
    Developmental Gene Expression 17
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:30650 Takizawa N, et al., Sequence of mouse CDC47, a member of the minichromosome maintenance (Mcm) family involved in the DNA replication licensing system. Gene. 1995 Dec 29;167(1-2):343-4
  • Latest
    J:221094 Carracedo S, et al., Redundant role of protein kinase C delta and epsilon during mouse embryonic development. PLoS One. 2014;9(8):e103686

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory