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Mcm2
Gene Detail
 Symbol
Name
ID
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
MGI:105380
Synonyms BM28, CDCL1, Mcmd2, mKIAA0030
Feature Type protein coding gene
Genetic Map
Chromosome 6
39.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:88883475-88898780 bp, - strand
From Ensembl annotation of GRCm38

  15306 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3325  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: replication licensing factor MCM2
Gene Tree: Mcm2

Human
homologs
Human Homolog MCM2, minichromosome maintenance complex component 2
NCBI Gene ID 4171
neXtProt AC  NX_P49736
Human Synonyms  BM28, CCNL1, cdc19, CDCL1, D3S3194, MITOTIN
Human Chr (Location)  3q21; chr3:127598357-127622436 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(31) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for non functional alleles at this locus die prematurely. There is an increased tumor incidence and abnormalities in a variety of systems in mice as they become moribund.
 
Interactions
Mcm2 interacts with 92 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cell cycle, cellular response to interleukin-4, ...
Component chromatin, cytoplasm, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (381)    Tissues (48)    Images (24)
Theiler Stages: 15, 17, 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 380
RT-PCR 1
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000002870 (Evidence)
Entrez Gene17216 (Evidence)
DFCITC1573899, TC1711545
DoTSDT.101190303, DT.101393079, DT.94166004, DT.99865300
NIA Mouse Gene IndexU027599
EC3.6.4.12
Consensus CDS ProjectCCDS39554.1
International Mouse Knockout Project StatusMcm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002870 Ensembl Gene Model | MGI Sequence Detail 15306 C57BL/6J ±  kb
transcript ENSMUST00000058011 Ensembl | MGI Sequence Detail 3370 Not Applicable 
polypeptide ENSMUSP00000061923 Ensembl | MGI Sequence Detail 904 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008045 DNA replication licensing factor Mcm2
InterPro IPR018525 Mini-chromosome maintenance, conserved site
InterPro IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010242 DNA replication licensing factor MCM2
References (Earliest) J:30650 Takizawa N, et al., Sequence of mouse CDC47, a member of the minichromosome maintenance (Mcm) family involved in the DNA replication licensing system. Gene. 1995 Dec 29;167(1-2):343-4
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(58)
Other
accession IDs
MGD-MRK-33049, MGI:2141373, MGI:2144533

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory