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Mcm2
Gene Detail
Symbol

Name
ID
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
MGI:105380
Synonyms
BM28, CDCL1, Mcmd2, mKIAA0030
Feature Type
protein coding gene
Genetic Map
Chromosome 6
39.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:88883475-88898780 bp, - strand
From Ensembl annotation of GRCm38

  15306 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3325  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MCM2
Protein SuperFamily: replication licensing factor MCM2
Gene Tree: Mcm2

Human
homologs
MCM2, minichromosome maintenance complex component 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4171
neXtProt AC: NX_P49736

Human Synonyms: BM28, CCNL1, cdc19, CDCL1, D3S3194, MITOTIN

Human Chr (Location): 3q21; chr3:127598357-127622436 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(31) Spontaneous(1) Targeted(3)
Genomic Mutations involving Mcm2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for non functional alleles at this locus die prematurely. There is an increased tumor incidence and abnormalities in a variety of systems in mice as they become moribund.
 
Interactions
Mcm2 interacts with 92 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cell cycle, cellular response to interleukin-4, ...
Component chromatin, cytoplasm, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (381)    Tissues (48)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 380
RT-PCR 1
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MCM2 ; Xenbase mcm2    NEW 
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000002870 (Evidence)
Entrez Gene 17216 (Evidence)
DFCI TC1711545, TC1573899
DoTS DT.101190303, DT.94166004, DT.101393079, DT.99865300
NIA Mouse Gene Index U027599
EC 3.6.4.12
Consensus CDS Project CCDS39554.1
International Mouse Phenotyping Consortium Status Mcm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002870 Ensembl Gene Model | MGI Sequence Detail 15306 C57BL/6J ±  kb
transcript ENSMUST00000058011 Ensembl | MGI Sequence Detail 3370 Not Applicable 
polypeptide ENSMUSP00000061923 Ensembl | MGI Sequence Detail 904 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008045 DNA replication licensing factor Mcm2
InterPro IPR018525 Mini-chromosome maintenance, conserved site
InterPro IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010242 DNA replication licensing factor MCM2
References
(Earliest) J:30650 Takizawa N, et al., Sequence of mouse CDC47, a member of the minichromosome maintenance (Mcm) family involved in the DNA replication licensing system. Gene. 1995 Dec 29;167(1-2):343-4
(Latest) J:221094 Carracedo S, et al., Redundant role of protein kinase C delta and epsilon during mouse embryonic development. PLoS One. 2014;9(8):e103686
All references(59)
Other
accession IDs
MGD-MRK-33049, MGI:2141373, MGI:2144533

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory