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Adam9 Gene Detail
Summary
  • Symbol
    Adam9
  • Name
    a disintegrin and metallopeptidase domain 9 (meltrin gamma)
  • Synonyms
    MDC9, MDC9, mKIAA0021, Mltng, Mltng
  • Feature Type
    protein coding gene
  • IDs
    MGI:105376
    NCBI Gene: 11502
  • Gene Overview
    MyGene.info: ADAM9
Location & Maps
more
  • Sequence Map
    Chr8:24949611-25016927 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67317 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 13.70 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ADAM9, ADAM metallopeptidase domain 9
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADAM9, ADAM metallopeptidase domain 9
    Orthology source: HomoloGene
  • Synonyms
    CORD9, MCMP, MDC9, Mltng
  • Links
    NCBI Gene ID: 8754
    neXtProt AC: NX_Q13443

  • Chr Location
    8p11.22; chr8:38996965-39105261 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Adam9 mouse models; 1 with human ADAM9 associations

Human Disease Mouse Models
       Cone-Rod Dystrophy 9; CORD9   OMIM: 612775 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    15 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout mice exhibit progressive retinal degeneration, disorganized retinal layers and a degenerate retinal pigment epithelium.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060065 VEGA Gene Model | MGI Sequence Detail 67317 C57BL/6J ±  kb
transcript OTTMUST00000147037 VEGA | MGI Sequence Detail 4044 Not Applicable  
polypeptide OTTMUSP00000076508 VEGA | MGI Sequence Detail 863 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    321 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 133
    cDNA 131
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-33045, MGI:2142696
References
more
  • Summaries
    All 59
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 14
    Phenotypes 16
  • Earliest
    J:30468 Weskamp G, et al., A family of cellular proteins related to snake venom disintegrins. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2748-51
  • Latest
    J:222585 Wong E, et al., The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site. J Biol Chem. 2015 May 8;290(19):12135-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory