Adam9
Gene Detail

Symbol Name ID

Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma) MGI:105376

Synonyms

MDC9, MDC9, mKIAA0021, Mltng, Mltng

Feature Type

protein coding gene

Genetic Map

Chromosome 8

13.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:24949611-25016922 bp, - strand From NCBI annotation of GRCm38   67312 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20824  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Adam9

Human homologs

Human Homolog		ADAM9, ADAM metallopeptidase domain 9
NCBI Gene ID		8754
neXtProt AC		NX_Q13443
Human Synonyms		CORD9, MCMP, MDC9, Mltng
Human Chr (Location)		8p11.22; chr8:38854505-38962780 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ADAM9

Alleles and phenotypes

All alleles(8) : Targeted(2) Gene trapped(6)
 

Homozygous mutation of this gene does not result in a phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (48 annotations)

Process	activation of MAPKK activity, cell adhesion, ...
Component	basolateral plasma membrane, cell surface, ...
Function	collagen binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (29)    Tissues (20)    Images (19)
Theiler Stages: 15, 16, 20, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	19
RNA in situ	9
RT-PCR	1

cDNA source data(130)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(132) cDNA(130) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000031555 (Evidence)
Entrez Gene	11502 (Evidence)
UniGene	28908
DFCI	TC1574038, TC1601301
DoTS	DT.533295, DT.94190555
NIA Mouse Gene Index	U029657
EC	3.4.24.-
International Mouse Knockout Project Status	Adam9

Sequences

Length	Strain/Species
genomic	11502	NCBI Gene Model | MGI Sequence Detail	67312	C57BL/6J
transcript	NM_001270996	RefSeq | MGI Sequence Detail	4057	C57BL/6
polypeptide	Q61072	UniProt | EBI | MGI Sequence Detail	845	Not Applicable

All sequences(34) RefSeq(4) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(287 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006586	ADAM, cysteine-rich
InterPro	IPR001762	Blood coagulation inhibitor, Disintegrin
InterPro	IPR018358	Disintegrin, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR001590	Peptidase M12B, ADAM/reprolysin
InterPro	IPR002870	Peptidase M12B, propeptide
Protein Ontology	PR:000003725	disintegrin and metalloproteinase domain-containing protein 9

Graphical View of Protein Domain Structure

References

(Earliest) J:30468 Weskamp G, et al., A family of cellular proteins related to snake venom disintegrins. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2748-51
(Latest) J:189567 Abety AN, et al., Stromal fibroblast-specific expression of ADAM-9 modulates proliferation and apoptosis in melanoma cells in vitro and in vivo. J Invest Dermatol. 2012 Oct;132(10):2451-8
All references(58)

Other accession IDs

MGD-MRK-33045, MGI:2142696