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Sstr4 Gene Detail
Summary
  • Symbol
    Sstr4
  • Name
    somatostatin receptor 4
  • Synonyms
    Smstr4, sst4
  • Feature Type
    protein coding gene
  • IDs
    MGI:105372
    NCBI Gene: 20608
  • Gene Overview
    MyGene.info: SSTR4
Location & Maps
more
  • Sequence Map
    Chr2:148395344-148396767 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1424 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 73.44 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    SSTR4, somatostatin receptor 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SSTR4, somatostatin receptor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SS4R, SS-4-R, SS4-R
  • Links
    NCBI Gene ID: 6754
    neXtProt AC: NX_P31391

  • Chr Location
    20p11.2; chr20:23035420-23036677 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Sstr4
  • Incidental Mutations
Homozygote null mice have increased susceptibility to inflammation, delayed type hypersensitivity, hyperalgesia and airway hypersensitivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015711 VEGA Gene Model | MGI Sequence Detail 1424 C57BL/6J ±  kb
transcript OTTMUST00000037330 VEGA | MGI Sequence Detail 1424 Not Applicable  
polypeptide OTTMUSP00000016722 VEGA | MGI Sequence Detail 385 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    20 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR001512 Somatostatin receptor 4
    IPR000586 Somatostatin receptor family
Molecular
Reagents
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  • All nucleic 13
    Genomic 3
    cDNA 7
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-33041
References
more
  • Summaries
    All 43
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:31780 Schwabe W, et al., Isolation and characterization of the mouse (Mus musculus) somatostatin receptor type-4-encoding gene (mSSTR4). Gene. 1996 Feb 12;168(2):233-5
  • Latest
    J:212202 Somvanshi RK, et al., delta-opioid receptor and somatostatin receptor-4 heterodimerization: possible implications in modulation of pain associated signaling. PLoS One. 2014;9(1):e85193

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory