Sstr4
Gene Detail

Symbol Name ID

Sstr4 somatostatin receptor 4 MGI:105372

Synonyms

Smstr4, sst4

Feature Type

protein coding gene

Genetic Map

Chromosome 2

73.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr2:148395344-148396767 bp, + strand From VEGA annotation of GRCm38   1424 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20286  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 zebrafish

Protein SuperFamily: somatostatin receptor
Gene Tree: Sstr4

Human homologs

Human Homolog		SSTR4, somatostatin receptor 4
NCBI Gene ID		6754
neXtProt AC		NX_P31391
Human Synonyms		SS4R, SS-4-R, SS4-R
Human Chr (Location)		20p11.2; chr20:23016057-23017314 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygote null mice have increased susceptibility to inflammation, delayed type hypersensitivity, hyperalgesia and airway hypersensitivity.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	arachidonic acid metabolic process, cell migration, ...
Component	cytoplasm, integral to membrane, ...
Function	G-protein coupled receptor activity, signal transducer activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (165)    Tissues (66)    Images (11)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	27
RT-PCR	138

cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(11) Genomic(3) cDNA(5) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000015711 (Evidence)
Ensembl Gene Model	ENSMUSG00000037014 (Evidence)
Entrez Gene	20608 (Evidence)
DFCI	TC1587823, TC1673196
DoTS	DT.110690478, DT.55171894, DT.91552020
NIA Mouse Gene Index	U002597
Consensus CDS Project	CCDS38260.1
International Mouse Knockout Project Status	Sstr4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015711	VEGA Gene Model | MGI Sequence Detail	1424	C57BL/6J
transcript	OTTMUST00000037330	VEGA | MGI Sequence Detail	1424	Not Applicable
polypeptide	OTTMUSP00000016722	VEGA | MGI Sequence Detail	385	Not Applicable

All sequences(26) RefSeq(2) UniProt(1)

Polymorphisms

PCR(1) : SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000586	Somatostatin receptor
InterPro	IPR001512	Somatostatin receptor, type 4
Protein Ontology	PR:000001671	somatostatin receptor 4

References

(Earliest) J:31780 Schwabe W, et al., Isolation and characterization of the mouse (Mus musculus) somatostatin receptor type-4-encoding gene (mSSTR4). Gene. 1996 Feb 12;168(2):233-5
(Latest) J:185665 Guo Z, et al., Tlx1/3 and ptf1a control the expression of distinct sets of transmitter and Peptide receptor genes in the developing dorsal spinal cord. J Neurosci. 2012 Jun 20;32(25):8509-20
All references(42)

Other accession IDs

MGD-MRK-33041