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Bst1 Gene Detail
Summary
  • Symbol
    Bst1
  • Name
    bone marrow stromal cell antigen 1
  • Synonyms
    114/A10, Bp3, Bsta1, CD157, Ly65
  • Feature Type
    protein coding gene
  • IDs
    MGI:105370
    NCBI Gene: 12182
  • Gene Overview
    MyGene.info: BST1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:43818885-43843986 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25102 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 23.84 cM
  • Mapping Data
    8 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    BST1, bone marrow stromal cell antigen 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    BST1, bone marrow stromal cell antigen 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD157
  • Links
    NCBI Gene ID: 683
    neXtProt AC: NX_Q10588
    UniProt: Q10588

  • Chr Location
    4p15.32; chr4:15686347-15774177 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice show delayed peritoneal B-1 cell development and a rise in CD38low/- B-lineage cells in bone marrow and spleen. The systemic thymus-independent-2 antigen-induced IgG3 and mucosal thymus-dependent antigen-elicited IgA responses are selectively impaired.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000053753 VEGA Gene Model | MGI Sequence Detail 25102 C57BL/6J ±  kb
    transcript OTTMUST00000066188 VEGA | MGI Sequence Detail 2856 Not Applicable  
    polypeptide OTTMUSP00000033125 VEGA | MGI Sequence Detail 311 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      200 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • EC
    • InterPro Domains
      IPR003193 ADP-ribosyl cyclase (CD38/157)
    Molecular
    Reagents
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    • All nucleic 31
      Genomic 7
      cDNA 23
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-19639, MGD-MRK-27081, MGD-MRK-33039, MGI:104718
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 4
      Phenotypes 23
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:260400 Wakabayashi T, et al., CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties. Cell Stem Cell. 2018 Mar 1;22(3):384-397.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory