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Bst1
Gene Detail
 Symbol
Name
ID
Bst1
bone marrow stromal cell antigen 1
MGI:105370
STS D5Dmo8
Synonyms 114/A10, Bp3, Bsta1, CD157, Ly65
Feature Type protein coding gene
Genetic Map
Chromosome 5
23.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr5:43818886-43843247 bp, + strand
From VEGA annotation of GRCm38

  24362 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3198  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: ADP-ribosyl cyclase CD38
Gene Tree: Bst1

Human
homologs
Human Homolog BST1, bone marrow stromal cell antigen 1
NCBI Gene ID 683
neXtProt AC  NX_Q10588
Human Synonyms  CD157
Human Chr (Location)  4p15; chr4:15702950-15739498 (+)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice show delayed peritoneal B-1 cell development and a rise in CD38low/- B-lineage cells in bone marrow and spleen. The systemic thymus-independent-2 antigen-induced IgG3 and mucosal thymus-dependent antigen-elicited IgA responses are selectively impaired.
 
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Component anchored component of membrane, extracellular vesicular exosome, ...
Function hydrolase activity, NAD+ nucleosidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(31) Genomic(6) cDNA(23) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026761 (Evidence)
Ensembl Gene ModelENSMUSG00000029082 (Evidence)
Entrez Gene12182 (Evidence)
UniGene246332
DFCITC1582441, TC1724176
DoTSDT.101358983, DT.490648, DT.97371279
NIA Mouse Gene IndexU005545
EC3.2.2.6
Consensus CDS ProjectCCDS19264.1
International Mouse Knockout Project StatusBst1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026761 VEGA Gene Model | MGI Sequence Detail 24362 C57BL/6J ±  kb
transcript OTTMUST00000066188 VEGA | MGI Sequence Detail 2115 Not Applicable 
polypeptide OTTMUSP00000033125 VEGA | MGI Sequence Detail 311 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(3)
Polymorphisms RFLP(3) : SNPs within 2kb(198 from dbSNP Build 137)    SNPs within 2kb including multiple locations(202)
Protein-related
information
ResourceIDDescription
InterPro IPR003193 ADP-ribosyl cyclase (CD38/157)
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000001409 ADP-ribosyl cyclase 2
References (Earliest) J:9704 Dougherty GJ, et al., Molecular cloning of 114/A10, a cell surface antigen containing highly conserved repeated elements, which is expressed by murine hemopoietic progenitor cells and interleukin-3-dependent cell lines. J Biol Chem. 1989 Apr 15;264(11):6509-14
(Latest) J:186706 Yilmaz OH, et al., mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature. 2012 Jun 28;486(7404):490-5
All references(42)
Other
accession IDs
MGD-MRK-19639, MGD-MRK-27081, MGD-MRK-33039, MGI:104718

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory