Atp2b2
Gene Detail

Symbol Name ID

Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 MGI:105368

Synonyms

D6Abb2e, jog, PMCA2, Tmy, wms

Feature Type

protein coding gene

Genetic Map

Chromosome 6

52.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(23)

Sequence Map

Chr6:113745669-114042613 bp, - strand From VEGA annotation of GRCm38   296945 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56150  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp2b2

Human homologs

Human Homolog		ATP2B2, ATPase, Ca++ transporting, plasma membrane 2
NCBI Gene ID		491
neXtProt AC		NX_Q01814
Human Synonyms		PMCA2, PMCA2a, PMCA2i
Human Chr (Location)		3p25.3; chr3:10365707-10547268 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ATP2B2

Alleles and phenotypes

All alleles(14) : Targeted(3) Gene trapped(2) Spontaneous(7) Chemically induced(2)
 

Homozygous mutants exhibit slower growth, balance problems, and deafness, associated with cerebellar abnormalities, an absence of otoconia, and abnormalities of the organ of Corti. Heterozygotes exhibit appreciable age-dependent hearing loss.

 
Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (86 annotations)

Process	ATP catabolic process, auditory receptor cell stereocilium organization, ...
Component	apical plasma membrane, cilium, ...
Function	acetylcholine receptor binding, ATP binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (167)    Tissues (106)    Images (26)
Theiler Stages: 15, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	155
Western blot	5
RT-PCR	7

cDNA source data(38)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(52) Genomic(9) cDNA(41) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000018967 (Evidence)
Ensembl Gene Model	ENSMUSG00000030302 (Evidence)
Entrez Gene	11941 (Evidence)
UniGene	321755
DFCI	TC1580453, TC1623719, TC1653818
DoTS	DT.103564295, DT.110498239, DT.55210906, DT.60105276, DT.91322618, DT.94171484, DT.97332447
NIA Mouse Gene Index	U027743
EC	3.6.3.8
Consensus CDS Project	CCDS20433.1
International Mouse Knockout Project Status	Atp2b2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018967	VEGA Gene Model | MGI Sequence Detail	296945	C57BL/6J
transcript	OTTMUST00000045567	VEGA | MGI Sequence Detail	4586	Not Applicable
polypeptide	OTTMUSP00000020493	VEGA | MGI Sequence Detail	1243	Not Applicable

All sequences(62) RefSeq(4) UniProt(6)

Polymorphisms

SNPs(1506 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022141	Calcium transporting P-type ATPase, C-terminal, plasma membrane
InterPro	IPR006408	Calcium-transporting P-type ATPase, subfamily IIB
InterPro	IPR001757	Cation-transporting P-type ATPase
InterPro	IPR006068	Cation-transporting P-type ATPase, C-terminal
InterPro	IPR004014	Cation-transporting P-type ATPase, N-terminal
InterPro	IPR023214	HAD-like domain
InterPro	IPR008250	P-type ATPase, A domain
InterPro	IPR023299	P-type ATPase, cytoplasmic domain N
InterPro	IPR018303	P-type ATPase, phosphorylation site
InterPro	IPR023298	P-type ATPase, transmembrane domain
Protein Ontology	PR:000004446	plasma membrane calcium-transporting ATPase 2

References

(Earliest) J:14114 Lane PW, Deaf waddler (dfw). Mouse News Lett. 1987;77:129
(Latest) J:184893 Gomez-Varela D, et al., PMCA2 via PSD-95 controls calcium signaling by alpha7-containing nicotinic acetylcholine receptors on aspiny interneurons. J Neurosci. 2012 May 16;32(20):6894-905
All references(91)

Other accession IDs

MGD-MRK-15437, MGD-MRK-15460, MGD-MRK-32111, MGD-MRK-33037, MGD-MRK-8835, MGI:2158365, MGI:3664090, MGI:94888, MGI:98965