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Atp2b2 Gene Detail
Summary
  • Symbol
    Atp2b2
  • Name
    ATPase, Ca++ transporting, plasma membrane 2
  • Synonyms
    D6Abb2e, Gena300, jog, PMCA2, Tmy, wms
  • Feature Type
    protein coding gene
  • IDs
    MGI:105368
    NCBI Gene: 11941
  • Gene Overview
    MyGene.info: ATP2B2
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113743842-114042613 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 52.85 cM
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2272 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105368
protein coding gene Chr6:113743831-114042613 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031138
protein coding gene Chr6:116290046-116603150 (-)
A/J MGP_AJ_G0031107
protein coding gene Chr6:111824024-112125149 (-)
AKR/J MGP_AKRJ_G0031038
protein coding gene Chr6:114830095-115142365 (-)
BALB/cJ MGP_BALBcJ_G0031118
protein coding gene Chr6:111769399-112072626 (-)
C3H/HeJ MGP_C3HHeJ_G0030590
protein coding gene Chr6:69157301-69463367 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031577
protein coding gene Chr6:119288577-119598194 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028741
protein coding gene Chr6:108851636-109155887 (-)
CAST/EiJ MGP_CASTEiJ_G0030225
protein coding gene Chr6:115289203-115606713 (-)
CBA/J MGP_CBAJ_G0030804
protein coding gene Chr6:124010696-124349058 (-)
DBA/2J MGP_DBA2J_G0030957
protein coding gene Chr6:110905092-111204595 (-)
FVB/NJ MGP_FVBNJ_G0030911
protein coding gene Chr6:109909236-110215627 (-)
LP/J MGP_LPJ_G0031037
protein coding gene Chr6:116314011-116620748 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030945
protein coding gene Chr6:128243816-128555323 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031604
protein coding gene Chr6:114855486-115167654 (-)
PWK/PhJ MGP_PWKPhJ_G0029941
protein coding gene Chr6:109867293-110173109 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029769
protein coding gene Chr6:113658918-113968193 (-)
WSB/EiJ MGP_WSBEiJ_G0030309
protein coding gene Chr6:115225533-115534077 (-)



Homology
more
  • Human Ortholog
    ATP2B2, ATPase plasma membrane Ca2+ transporting 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ATP2B2, ATPase plasma membrane Ca2+ transporting 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PMCA2, PMCA2a, PMCA2i
  • Links
    NCBI Gene ID: 491
    neXtProt AC: NX_Q01814
    UniProt: Q01814

  • Chr Location
    3p25.3; chr3:10324023-10707962 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ATP2B2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    83 phenotypes from 13 alleles in 19 genetic backgrounds
    21 phenotypes from multigenic genotypes
    4 images
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit slower growth, balance problems, and deafness, associated with cerebellar abnormalities, an absence of otoconia, and abnormalities of the organ of Corti. Heterozygotes exhibit appreciable age-dependent hearing loss.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11941 NCBI Gene Model | MGI Sequence Detail 298772 C57BL/6J ±  kb
    transcript NM_001347365 RefSeq | MGI Sequence Detail 9064 C57BL/6  
    polypeptide Q9R0K7 UniProt | EBI | MGI Sequence Detail 1198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • EC
    • InterPro Domains
      IPR006068 Cation-transporting P-type ATPase, C-terminal
      IPR004014 Cation-transporting P-type ATPase, N-terminal
      IPR036412 HAD-like superfamily
      IPR023214 HAD superfamily
      IPR030322 Plasma membrane calcium-transporting ATPase 2
      IPR022141 Plasma membrane calcium transporting P-type ATPase, C-terminal
      IPR001757 P-type ATPase
      IPR008250 P-type ATPase, A domain superfamily
      IPR023299 P-type ATPase, cytoplasmic domain N
      IPR018303 P-type ATPase, phosphorylation site
      IPR006408 P-type ATPase, subfamily IIB
      IPR023298 P-type ATPase, transmembrane domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 9
      cDNA 13
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15437, MGD-MRK-15460, MGD-MRK-32111, MGD-MRK-33037, MGD-MRK-8835, MGI:2158365, MGI:3664090, MGI:5490332, MGI:94888, MGI:98965
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 8
      Gene Ontology 27
      Phenotypes 58
    • Earliest
      J:19948 Matsui K, et al., [Fundamental study on ataxic mice (wriggle mouse Sagami)]. Jikken Dobutsu. 1987 Apr;36(2):185-9
    • Latest
      J:245773 Paikari A, et al., The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport. Development. 2017 Oct 15;144(20):3731-3743

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory