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Cit Gene Detail
Summary
  • Symbol
    Cit
  • Name
    citron
  • Synonyms
    C030025P15Rik, Cit-k, citron kinase, citron-N, CRIK, CRIK-SK
  • Feature Type
    protein coding gene
  • IDs
    MGI:105313
    NCBI Gene: 12704
  • Gene Overview
    MyGene.info: CIT
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:115845278-116008947 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      163670 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 56.10 cM, cytoband F
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CIT, citron rho-interacting serine/threonine kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CIT, citron rho-interacting serine/threonine kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CITK, CRIK, MCPH17, STK21
  • Links
    NCBI Gene ID: 11113
    neXtProt AC: NX_O14578
    UniProt: O14578

  • Chr Location
    12q24.23; chr12:119685790-119877318 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CIT associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null mutation are 20% smaller than wild-type and exhibit tremors, ataxia, and fatal seizures. Brains of mutant mice show a 50% size reduction with abnormalities in the hippocampus, cerebellum, and olfactory lobes. Mutant males show aberrant cytokinesis of spermatogenic precursors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000014714 VEGA Gene Model | MGI Sequence Detail 163670 C57BL/6J ±  kb
    transcript OTTMUST00000041064 VEGA | MGI Sequence Detail 6213 Not Applicable  
    polypeptide OTTMUSP00000018399 VEGA | MGI Sequence Detail 2070 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1453 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • EC
    • InterPro Domains
      IPR000961 AGC-kinase, C-terminal
      IPR001180 Citron homology (CNH) domain
      IPR017405 Citron Rho-interacting kinase
      IPR037708 Citron Rho-interacting kinase, catalytic domain
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR017441 Protein kinase, ATP binding site
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 16
      Primer pair 5

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-32354, MGI:2444984
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 10
      Gene Ontology 12
      Phenotypes 21
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:264274 Pallavicini G, et al., Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence. Cancer Res. 2018 Aug 15;78(16):4599-4612

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/18/2018
    MGI 6.12
    The Jackson Laboratory