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Cit Gene Detail
Summary
  • Symbol
    Cit
  • Name
    citron
  • Synonyms
    C030025P15Rik, Cit-k, citron kinase, citron-N, CRIK, CRIK-SK
  • Feature Type
    protein coding gene
  • IDs
    MGI:105313
    NCBI Gene: 12704
  • Gene Overview
    MyGene.info: CIT
Location & Maps
more
  • Sequence Map
    Chr5:115845278-116008947 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      163670 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CIT, citron rho-interacting serine/threonine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CIT, citron rho-interacting serine/threonine kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CRIK, STK21
  • Links
    NCBI Gene ID: 11113
    neXtProt AC: NX_O14578

  • Chr Location
    12q24; chr12:119685790-119877318 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    62
  • Chemically induced (other)
    1
  • Gene trapped
    58
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Cit
  • Incidental Mutations
Homozygotes for a null mutation are 20% smaller than wild-type and exhibit tremors, ataxia, and fatal seizures. Brains of mutant mice show a 50% size reduction with abnormalities in the hippocampus, cerebellum, and olfactory lobes. Mutant males show aberrant cytokinesis of spermatogenic precursors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014714 VEGA Gene Model | MGI Sequence Detail 163670 C57BL/6J ±  kb
transcript OTTMUST00000041064 VEGA | MGI Sequence Detail 6213 Not Applicable  
polypeptide OTTMUSP00000018399 VEGA | MGI Sequence Detail 2070 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1453 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 14
    Primer pair 5

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-32354, MGI:2444984
References
more
  • Summaries
    All 42
    Developmental Gene Expression 9
    Gene Ontology 12
    Phenotypes 17
  • Earliest
    J:30350 Madaule P, et al., A novel partner for the GTP-bound forms of rho and rac. FEBS Lett. 1995 Dec 18;377(2):243-8
  • Latest
    J:228026 Capecchi MR, et al., ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination. Nat Commun. 2015;6:8763

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory