About   Help   FAQ
Cit
Gene Detail
 Symbol
Name
ID
Cit
citron
MGI:105313
Synonyms C030025P15Rik, Cit-k, citron kinase, citron-N, CRIK, CRIK-SK
Feature Type protein coding gene
Genetic Map
Chromosome 5
56.10 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:115845278-116008947 bp, + strand
From VEGA annotation of GRCm38

  163670 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21404  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: citron Rho-interacting kinase
Gene Tree: Cit

Human
homologs
Human Homolog CIT, citron rho-interacting serine/threonine kinase
NCBI Gene ID 11113
neXtProt AC  NX_O14578
Human Synonyms  CRIK, STK21
Human Chr (Location)  12q24; chr12:119685790-119877291 (-)  GRCh38
Alleles
and
phenotypes
All alleles(61) : Gene trapped(59) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null mutation are 20% smaller than wild-type and exhibit tremors, ataxia, and fatal seizures. Brains of mutant mice show a 50% size reduction with abnormalities in the hippocampus, cerebellum, and olfactory lobes. Mutant males show aberrant cytokinesis of spermatogenic precursors.
 
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process cell cycle, cell differentiation, ...
Component actin cytoskeleton, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (247)    Tissues (59)    Images (37)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 240
Northern blot 7
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000014714 (Evidence)
Ensembl Gene ModelENSMUSG00000029516 (Evidence)
Entrez Gene12704 (Evidence)
DFCITC1582449, TC1592137, TC1594111, TC1612526, TC1780597
DoTSDT.101131988, DT.101218395, DT.101363982, DT.101734937, DT.485121, DT.60101674, DT.91315986, DT.91334932, DT.94393028, DT.94393038
NIA Mouse Gene IndexU040645
EC2.7.11.1
Consensus CDS ProjectCCDS19597.1
International Mouse Knockout Project StatusCit
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014714 VEGA Gene Model | MGI Sequence Detail 163670 C57BL/6J ±  kb
transcript OTTMUST00000041064 VEGA | MGI Sequence Detail 6213 Not Applicable 
polypeptide OTTMUSP00000018399 VEGA | MGI Sequence Detail 2070 Not Applicable 

For the selected sequences
All sequences(146) RefSeq(50) UniProt(9)
Polymorphisms SNPs within 2kb(1471 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR001180 Citron-like
InterPro IPR017405 Citron Rho-interacting kinase
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005504 citron Rho-interacting kinase
References (Earliest) J:30350 Madaule P, et al., A novel partner for the GTP-bound forms of rho and rac. FEBS Lett. 1995 Dec 18;377(2):243-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(44)
Other
accession IDs
MGD-MRK-32354, MGI:2444984

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory