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Ptpn3
Gene Detail
Symbol

Name
ID
Ptpn3
protein tyrosine phosphatase, non-receptor type 3
MGI:105307
Synonyms
9530011I20Rik, PTPCL, PTP-H1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
31.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:57190841-57301837 bp, - strand
From VEGA annotation of GRCm38

  110997 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74451  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PTPN3
Protein SuperFamily: non-receptor tyrosine-protein phosphatase, 3/4 types
Gene Tree: Ptpn3

Human
homologs
PTPN3, protein tyrosine phosphatase, non-receptor type 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5774
neXtProt AC: NX_P26045

Human Synonyms: PTPH1, PTP-H1

Human Chr (Location): 9q31; chr9:109375694-109538353 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(160) : Gene trapped(156) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit increased body weight, especially in males, and male mice exhibit increased bone mineral content.
 
Interactions
Ptpn3 interacts with 413 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (119)    Tissues (21)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 112
Northern blot 2
Western blot 5
cDNA source data(34)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ptpn3 ; ZFIN ptpn3    NEW 
Molecular
reagents
All nucleic(35) cDNA(34) Other(1)
Microarray probesets(13)
Other database
links
VEGA Gene Model OTTMUSG00000007367 (Evidence)
Ensembl Gene Model ENSMUSG00000038764 (Evidence)
Entrez Gene 545622 (Evidence)
UniGene 246552
DFCI TC1638328, TC1626985, TC1646558, TC1734180
DoTS DT.91402616, DT.101366763, DT.55145922, DT.525301, DT.110811814
NIA Mouse Gene Index U025102
EC 3.1.3.48
Consensus CDS Project CCDS51181.1
International Mouse Phenotyping Consortium Status Ptpn3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007367 VEGA Gene Model | MGI Sequence Detail 110997 C57BL/6J ±  kb
transcript OTTMUST00000017047 VEGA | MGI Sequence Detail 6369 Not Applicable 
polypeptide OTTMUSP00000007878 VEGA | MGI Sequence Detail 913 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(12) UniProt(7)
Polymorphisms
SNPs within 2kb(592 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR000798 Ezrin/radixin/moesin like
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
InterPro IPR019748 FERM central domain
InterPro IPR019747 FERM conserved site
InterPro IPR018980 FERM, C-terminal PH-like domain
InterPro IPR000299 FERM domain
InterPro IPR018979 FERM, N-terminal
InterPro IPR001478 PDZ domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR012151 Protein-tyrosine phosphatase, non-receptor type-3, -4
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000029701 tyrosine-protein phosphatase non-receptor type 3
References
(Earliest) J:30499 Messerle M, et al., Dynamic changes in gene expression during in vitro differentiation of mouse embryonic stem cells. Cytokines Mol Ther. 1995 Jun;1(2):139-43
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)
Other
accession IDs
MGD-MRK-32348, MGI:3026925

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory