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Ptpn3 Gene Detail
Summary
  • Symbol
    Ptpn3
  • Name
    protein tyrosine phosphatase, non-receptor type 3
  • Synonyms
    9530011I20Rik, PTPCL, PTP-H1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105307
    NCBI Gene: 545622
  • Gene Overview
    MyGene.info: PTPN3
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:57190841-57301837 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 31.66 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    653 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105307
protein coding gene Chr4:57190841-57339040 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028316
protein coding gene Chr4:55972458-56085355 (-)
A/J MGP_AJ_G0028277
protein coding gene Chr4:53841257-53953533 (-)
AKR/J MGP_AKRJ_G0028226
protein coding gene Chr4:55328406-55440533 (-)
BALB/cJ MGP_BALBcJ_G0028296
protein coding gene Chr4:53993793-54106073 (-)
C3H/HeJ MGP_C3HHeJ_G0028017
protein coding gene Chr4:55832836-55946915 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028737
protein coding gene Chr4:57972106-58084846 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026043
protein coding gene Chr4:50635326-50746910 (-)
CAST/EiJ MGP_CASTEiJ_G0027455
protein coding gene Chr4:55536077-55664285 (-)
CBA/J MGP_CBAJ_G0027982
protein coding gene Chr4:59969274-60086512 (-)
DBA/2J MGP_DBA2J_G0028132
protein coding gene Chr4:53740880-53852822 (-)
FVB/NJ MGP_FVBNJ_G0028099
protein coding gene Chr4:52963722-53083421 (-)
LP/J MGP_LPJ_G0028231
protein coding gene Chr4:56084350-56193999 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028123
protein coding gene Chr4:63109866-63226920 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028773
protein coding gene Chr4:55507012-55621458 (-)
PWK/PhJ MGP_PWKPhJ_G0027180
protein coding gene Chr4:53732729-53847312 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027008
protein coding gene Chr4:54771764-54895877 (-)
WSB/EiJ MGP_WSBEiJ_G0027533
protein coding gene Chr4:55462244-55576894 (-)



Homology
more
  • Human Ortholog
    PTPN3, protein tyrosine phosphatase, non-receptor type 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTPN3, protein tyrosine phosphatase, non-receptor type 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PTPH1, PTP-H1
  • Links
    NCBI Gene ID: 5774
    neXtProt AC: NX_P26045
    UniProt: P26045

  • Chr Location
    9q31.3; chr9:109375694-109538395 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 4 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased body weight, especially in males, and male mice exhibit increased bone mineral content.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038764 Ensembl Gene Model | MGI Sequence Detail 110997 C57BL/6J ±  kb
    transcript ENSMUST00000075637 Ensembl | MGI Sequence Detail 6369 Not Applicable  
    polypeptide ENSMUSP00000075063 Ensembl | MGI Sequence Detail 913 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 36
      Other 1

      Microarray probesets 13
    Other
    Accession IDs
    less
    MGD-MRK-32348, MGI:3026925
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:30499 Messerle M, et al., Dynamic changes in gene expression during in vitro differentiation of mouse embryonic stem cells. Cytokines Mol Ther. 1995 Jun;1(2):139-43
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory