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Rab5c
Gene Detail
 Symbol
Name
ID
Rab5c
RAB5C, member RAS oncogene family
MGI:105306
Feature Type protein coding gene
Genetic Map
Chromosome 11
63.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:100715009-100738215 bp, - strand
From VEGA annotation of GRCm38

  23207 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55533  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab5c

Human
homologs
Human Homolog RAB5C, RAB5C, member RAS oncogene family
NCBI Gene ID 5878
neXtProt AC  NX_P51148
Human Synonyms  L1880, RAB5CL, RAB5L, RABL
Human Chr (Location)  17q21.2; chr17:42124976-42155044 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(68) : Gene trapped(65) Targeted(3)
Interactions
Rab5c interacts with 185 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process endosome organization, GTP catabolic process, ...
Component cytoplasmic vesicle, endocytic vesicle, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (16)    Tissues (15)    Images (2)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
Northern blot 16
cDNA source data(155)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(157) Genomic(1) cDNA(155) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002056 (Evidence)
Ensembl Gene ModelENSMUSG00000019173 (Evidence)
Entrez Gene19345 (Evidence)
UniGene29829
DFCITC1573078, TC1581410
DoTSDT.495137, DT.99857671
NIA Mouse Gene IndexU033433
PDB1HUQ, 1Z0D, 1Z07
Consensus CDS ProjectCCDS36333.1
International Mouse Knockout Project StatusRab5c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002056 VEGA Gene Model | MGI Sequence Detail 23207 C57BL/6J ±  kb
transcript OTTMUST00000004177 VEGA | MGI Sequence Detail 1967 Not Applicable 
polypeptide OTTMUSP00000001996 VEGA | MGI Sequence Detail 234 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(6)
Polymorphisms SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013635 ras-related protein Rab-5C
References (Earliest) J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
(Latest) J:186386 Welliver TP, et al., A growth factor signaling cascade confined to circular ruffles in macrophages. Biol Open. 2012;1:754-760
All references(47)
Other
accession IDs
MGD-MRK-32347, MGI:2144132

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory