Rab5c
Gene Detail

Symbol Name ID

Rab5c RAB5C, member RAS oncogene family MGI:105306

Feature Type

protein coding gene

Genetic Map

Chromosome 11

63.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:100715009-100738215 bp, - strand From VEGA annotation of GRCm38   23207 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55533  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab5c

Human homologs

Human Homolog		RAB5C, RAB5C, member RAS oncogene family
NCBI Gene ID		5878
neXtProt AC		NX_P51148
Human Synonyms		L1880, RAB5CL, RAB5L, RABL
Human Chr (Location)		17q21.2; chr17:40276994-40307062 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(68) : Targeted(3) Gene trapped(65)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	endosome organization, GTP catabolic process, ...
Component	endocytic vesicle, endosome, ...
Function	GDP binding, GTPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (16)    Tissues (15)    Images (2)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
Northern blot	16

cDNA source data(154)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(156) Genomic(1) cDNA(154) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000002056 (Evidence)
Ensembl Gene Model	ENSMUSG00000019173 (Evidence)
Entrez Gene	19345 (Evidence)
UniGene	29829
DFCI	TC1573078, TC1581410
DoTS	DT.495137, DT.99857671
NIA Mouse Gene Index	U033433
PDB	1HUQ, 1Z0D, 1Z07
Consensus CDS Project	CCDS36333.1
International Mouse Knockout Project Status	Rab5c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002056	VEGA Gene Model | MGI Sequence Detail	23207	C57BL/6J
transcript	OTTMUST00000004177	VEGA | MGI Sequence Detail	1967	Not Applicable
polypeptide	OTTMUSP00000001996	VEGA | MGI Sequence Detail	234	Not Applicable

All sequences(46) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(61 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR003579	Small GTPase superfamily, Rab type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000013635	ras-related protein Rab-5C

References

(Earliest) J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
(Latest) J:186386 Welliver TP, et al., A growth factor signaling cascade confined to circular ruffles in macrophages. Biol Open. 2012;1:754-760
All references(46)

Other accession IDs

MGD-MRK-32347, MGI:2144132