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Rab5c Gene Detail
Summary
  • Symbol
    Rab5c
  • Name
    RAB5C, member RAS oncogene family
  • Feature Type
    protein coding gene
  • IDs
    MGI:105306
    NCBI Gene: 19345
  • Gene Overview
    MyGene.info: RAB5C
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100715009-100738215 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.54 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105306
protein coding gene Chr11:100715003-100738215 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019167
protein coding gene Chr11:103480507-103510817 (-)
A/J MGP_AJ_G0019135
protein coding gene Chr11:99165669-99189269 (-)
AKR/J MGP_AKRJ_G0019104
protein coding gene Chr11:102236676-102268148 (-)
BALB/cJ MGP_BALBcJ_G0019109
protein coding gene Chr11:99652891-99676535 (-)
C3H/HeJ MGP_C3HHeJ_G0018918
protein coding gene Chr11:102410061-102433320 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019558
protein coding gene Chr11:106694963-106718041 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017184
protein coding gene Chr11:96582499-96605656 (-)
CAST/EiJ MGP_CASTEiJ_G0018472
protein coding gene Chr11:103388575-103414696 (-)
CBA/J MGP_CBAJ_G0018887
protein coding gene Chr11:111148158-111176966 (-)
DBA/2J MGP_DBA2J_G0018999
protein coding gene Chr11:98702444-98725691 (-)
FVB/NJ MGP_FVBNJ_G0018989
protein coding gene Chr11:98240953-98264157 (-)
LP/J MGP_LPJ_G0019068
protein coding gene Chr11:104042159-104069398 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019020
protein coding gene Chr11:110734815-110758821 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019596
protein coding gene Chr11:102562342-102585584 (-)
PWK/PhJ MGP_PWKPhJ_G0018235
protein coding gene Chr11:99740270-99764673 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018027
protein coding gene Chr11:102306354-102329323 (-)
WSB/EiJ MGP_WSBEiJ_G0018521
protein coding gene Chr11:102550576-102575385 (-)



Homology
more
  • Human Ortholog
    RAB5C, RAB5C, member RAS oncogene family
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAB5C, RAB5C, member RAS oncogene family
    Orthology source: HomoloGene, HGNC
  • Synonyms
    L1880, RAB5CL, RAB5L, RABL
  • Links
    NCBI Gene ID: 5878
    neXtProt AC: NX_P51148
    UniProt: P51148

  • Chr Location
    17q21.2; chr17:42124976-42155044 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019173 Ensembl Gene Model | MGI Sequence Detail 23207 C57BL/6J ±  kb
    transcript ENSMUST00000019317 Ensembl | MGI Sequence Detail 1967 Not Applicable  
    polypeptide ENSMUSP00000019317 Ensembl | MGI Sequence Detail 234 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 158
      Genomic 2
      cDNA 155
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-32347, MGI:2144132
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
    • Latest
      J:186386 Welliver TP, et al., A growth factor signaling cascade confined to circular ruffles in macrophages. Biol Open. 2012;1:754-760

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory