About   Help   FAQ
Rab5c
Gene Detail
Symbol

Name
ID
Rab5c
RAB5C, member RAS oncogene family
MGI:105306
Feature Type
protein coding gene
Genetic Map
Chromosome 11
63.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:100715009-100738215 bp, - strand
From VEGA annotation of GRCm38

  23207 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55533  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RAB5C
Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab5c

Human
homologs
RAB5C, RAB5C, member RAS oncogene family
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5878
neXtProt AC: NX_P51148

Human Synonyms: L1880, RAB5CL, RAB5L, RABL

Human Chr (Location): 17q21.2; chr17:42124976-42155044 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(69) : Gene trapped(65) Targeted(4)
Genomic Mutations involving Rab5c (1)
Interactions
Rab5c interacts with 185 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process endosome organization, intracellular protein transport, ...
Component cytoplasmic vesicle, early endosome, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (16)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 16
cDNA source data(155)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rab5c ; ZFIN rab5c    NEW 
Molecular
reagents
All nucleic(157) Genomic(1) cDNA(155) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002056 (Evidence)
Ensembl Gene Model ENSMUSG00000019173 (Evidence)
Entrez Gene 19345 (Evidence)
UniGene 29829
DFCI TC1573078, TC1581410
DoTS DT.495137, DT.99857671
NIA Mouse Gene Index U033433
PDB 1HUQ, 1Z07, 1Z0D
Consensus CDS Project CCDS36333.1
International Mouse Phenotyping Consortium Status Rab5c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002056 VEGA Gene Model | MGI Sequence Detail 23207 C57BL/6J ±  kb
transcript OTTMUST00000004177 VEGA | MGI Sequence Detail 1967 Not Applicable 
polypeptide OTTMUSP00000001996 VEGA | MGI Sequence Detail 234 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013635 ras-related protein Rab-5C
References
(Earliest) J:24144 Chavrier P, et al., The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach. Gene. 1992 Mar 15;112(2):261-4
(Latest) J:186386 Welliver TP, et al., A growth factor signaling cascade confined to circular ruffles in macrophages. Biol Open. 2012;1:754-760
All references(47)
Other
accession IDs
MGD-MRK-32347, MGI:2144132

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory