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Slc1a5 Gene Detail
Summary
  • Symbol
    Slc1a5
  • Name
    solute carrier family 1 (neutral amino acid transporter), member 5
  • Synonyms
    ASCT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:105305
    NCBI Gene: 20514
  • Gene Overview
    MyGene.info: SLC1A5
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:16781345-16798274 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.15 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105305
protein coding gene Chr7:16781340-16798274 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031716
protein coding gene Chr7:14526195-14545134 (+)
A/J MGP_AJ_G0031688
protein coding gene Chr7:14259477-14277259 (+)
AKR/J MGP_AKRJ_G0031613
protein coding gene Chr7:14596509-14613138 (+)
BALB/cJ MGP_BALBcJ_G0031695
protein coding gene Chr7:14367307-14387187 (+)
C3H/HeJ MGP_C3HHeJ_G0031417
protein coding gene Chr7:14780512-14798643 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032161
protein coding gene Chr7:15269217-15285702 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029240
protein coding gene Chr7:15795531-15812619 (+)
CAST/EiJ MGP_CASTEiJ_G0030768
protein coding gene Chr7:11551997-11569491 (+)
CBA/J MGP_CBAJ_G0031376
protein coding gene Chr7:15759443-15776604 (+)
DBA/2J MGP_DBA2J_G0031532
protein coding gene Chr7:14150316-14167884 (+)
FVB/NJ MGP_FVBNJ_G0031488
protein coding gene Chr7:14050320-14067383 (+)
LP/J MGP_LPJ_G0031617
protein coding gene Chr7:14771619-14788622 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031523
protein coding gene Chr7:15694360-15711328 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032190
protein coding gene Chr7:14371285-14390207 (+)
PWK/PhJ MGP_PWKPhJ_G0030492
protein coding gene Chr7:11669289-11687235 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030319
protein coding gene Chr7:9301921-9320502 (+)
WSB/EiJ MGP_WSBEiJ_G0030865
protein coding gene Chr7:14440706-14460250 (+)



Homology
more
  • Human Ortholog
    SLC1A5, solute carrier family 1 member 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC1A5, solute carrier family 1 member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AAAT, ASCT2, ATBO, M7V1, M7VS1, R16, RDRC
  • Links
    NCBI Gene ID: 6510
    neXtProt AC: NX_Q15758
    UniProt: Q15758

  • Chr Location
    19q13.32; chr19:46759685-46788622 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced B cells, CD4+ memory T cells in older mice, Th1 and Th17 T cells, susceptibility to EAE and T cell uptake of glutamine and leucine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20514 NCBI Gene Model | MGI Sequence Detail 16930 C57BL/6J ±  kb
transcript NM_009201 RefSeq | MGI Sequence Detail 2758 C57BL/6  
polypeptide P51912 UniProt | EBI | MGI Sequence Detail 553 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR001991 Sodium:dicarboxylate symporter
    IPR018107 Sodium:dicarboxylate symporter, conserved site
    IPR036458 Sodium:dicarboxylate symporter superfamily
Molecular
Reagents
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  • All nucleic 112
    cDNA 111
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-32346
References
more
  • Summaries
    All 30
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:24181 Liao K, et al., Expression of a novel insulin-activated amino acid transporter gene during differentiation of 3T3-L1 preadipocytes into adipocytes. Biochem Biophys Res Commun. 1995 Mar 28;208(3):1008-15
  • Latest
    J:245127 Seyer P, et al., Physical and functional interactions between the serotonin transporter and the neutral amino acid transporter ASCT2. Biochem J. 2016 Jul 1;473(13):1953-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory