Cxcr2
Gene Detail

Symbol Name ID

Cxcr2 chemokine (C-X-C motif) receptor 2 MGI:105303

Synonyms

CD128, Cmkar2, Gpcr16, IL8RA, Il8rb, IL-8rb, IL-8Rh

Feature Type

protein coding gene

Genetic Map

Chromosome 1

38.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr1:74153989-74161238 bp, + strand From Ensembl annotation of GRCm38   7250 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10439  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 2 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: chemokine receptor
Gene Tree: Cxcr2

Human homologs

Human Homolog		CXCR2, chemokine (C-X-C motif) receptor 2
NCBI Gene ID		3579
neXtProt AC		NX_P25025
Human Synonyms		CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB
Human Chr (Location)		2q35; chr2:218990013-219001976 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a targeted null mutation are viable and fertile but exhibit splenomegaly, lymphadenopathy, and increased susceptibility to various pathogens due to impaired neutrophil recruitment and decreased pathogen clearance during innate immune responses.

 

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	apoptotic process, cell surface receptor signaling pathway, ...
Component	cell surface, integral to membrane, ...
Function	chemokine binding, chemokine receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (83)    Tissues (79)    Images (1)
Theiler Stages: 13, 15, 19, 20, 21, 22, 23, 25

Assay Type	Results
Immunohistochemistry	72
RT-PCR	6
RNase protection	5

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(6) cDNA(14) Primer pair(2) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000026180 (Evidence)
Entrez Gene	12765 (Evidence)
UniGene	234466
DFCI	TC1590710, TC1620262
DoTS	DT.101338892, DT.87069995
NIA Mouse Gene Index	U000440
Consensus CDS Project	CCDS15040.1
International Mouse Knockout Project Status	Cxcr2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000026180	Ensembl Gene Model | MGI Sequence Detail	7250	C57BL/6J
transcript	ENSMUST00000027372	Ensembl | MGI Sequence Detail	2220	Not Applicable
polypeptide	ENSMUSP00000027372	Ensembl | MGI Sequence Detail	359	Not Applicable

All sequences(23) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(9) : PCR(1) RFLP(8) SNPs(60 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000174	CXC chemokine receptor/Interleukin-8 receptor
InterPro	IPR000057	CXC chemokine receptor, type 2/Interleukin 8 receptor beta
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001257	high affinity interleukin-8 receptor B

References

(Earliest) J:15235 Mock BA, et al., Genetic mapping of tumor susceptibility genes involved in mouse plasmacytomagenesis. Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9499-503
(Latest) J:195210 Baluk P, et al., Transgenic overexpression of interleukin-1beta induces persistent lymphangiogenesis but not angiogenesis in mouse airways. Am J Pathol. 2013 Apr;182(4):1434-47
All references(159)

Other accession IDs

MGD-MRK-11396, MGD-MRK-16347, MGD-MRK-32344, MGI:99567