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Cxcr2
Gene Detail
 Symbol
Name
ID
Cxcr2
chemokine (C-X-C motif) receptor 2
MGI:105303
Synonyms CD128, Cmkar2, Gpcr16, IL8RA, Il8rb, IL-8rb, IL-8Rh
Feature Type protein coding gene
Genetic Map
Chromosome 1
38.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr1:74153989-74161238 bp, + strand
From Ensembl annotation of GRCm38

  7250 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10439  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 zebrafish

Protein SuperFamily: chemokine receptor
Gene Tree: Cxcr2

Human
homologs
Human Homolog CXCR2, chemokine (C-X-C motif) receptor 2
NCBI Gene ID 3579
neXtProt AC  NX_P25025
Human Synonyms  CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB
Human Chr (Location)  2q35; chr2:218125290-218137253 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation are viable and fertile but exhibit splenomegaly, lymphadenopathy, and increased susceptibility to various pathogens due to impaired neutrophil recruitment and decreased pathogen clearance during innate immune responses.
 
Interactions
Cxcr2 interacts with 223 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process acute inflammatory response to antigenic stimulus, cell surface receptor signaling pathway, ...
Component cell surface, cytosol, ...
Function chemokine receptor activity, C-X-C chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (83)    Tissues (79)    Images (1)
Theiler Stages: 13, 15, 19, 20, 21, 22, 23, 25
Assay TypeResults
Immunohistochemistry 72
RT-PCR 6
RNase protection 5
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(6) cDNA(14) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000026180 (Evidence)
Entrez Gene12765 (Evidence)
UniGene234466
DFCITC1590710, TC1620262
DoTSDT.101338892, DT.87069995
NIA Mouse Gene IndexU000440
Consensus CDS ProjectCCDS15040.1
International Mouse Knockout Project StatusCxcr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026180 Ensembl Gene Model | MGI Sequence Detail 7250 C57BL/6J ±  kb
transcript ENSMUST00000027372 Ensembl | MGI Sequence Detail 2220 Not Applicable 
polypeptide ENSMUSP00000027372 Ensembl | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(1)
Polymorphisms All PCR and RFLP(9) : PCR(1) RFLP(8) SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR000174 CXC chemokine receptor 1/2
InterPro IPR000057 CXC chemokine receptor 2
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001257 C-X-C chemokine receptor type 2
References (Earliest) J:15235 Mock BA, et al., Genetic mapping of tumor susceptibility genes involved in mouse plasmacytomagenesis. Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9499-503
(Latest) J:209364 West DM, et al., CXCL1 but not IL-6 is required for recurrent herpetic stromal keratitis. J Immunol. 2014 Feb 15;192(4):1762-7
All references(174)
Other
accession IDs
MGD-MRK-11396, MGD-MRK-16347, MGD-MRK-32344, MGI:99567

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory