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Rad23b
Gene Detail
Symbol

Name
ID
Rad23b
RAD23b homolog (S. cerevisiae)
MGI:105128
Synonyms
0610007D13Rik, mHR23B
Feature Type
protein coding gene
Genetic Map
Chromosome 4
29.70 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:55350043-55392237 bp, + strand
From VEGA annotation of GRCm38

  42195 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37704  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RAD23B
Gene Tree: Rad23b

Human
homologs
RAD23B, RAD23 homolog B, nucleotide excision repair protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5887
neXtProt AC: NX_P54727

Human Synonyms: HHR23B, HR23B, P58

Human Chr (Location): 9q31.2; chr9:107283236-107332194 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(58) : Gene trapped(56) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption in this gene usually die around the time of birth. Those that survive show growth retardation, eye, reproductive, behavioral, and digestive system abnormalities. They usually die within 1 year of birth.
 
Interactions
Rad23b interacts with 345 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component cytoplasm, nucleoplasm, ...
Function damaged DNA binding, polyubiquitin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (47)    Tissues (36)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 47
cDNA source data(201)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rad23b ; ZFIN rad23b    NEW 
Molecular
reagents
All nucleic(203) Genomic(1) cDNA(202)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000007227 (Evidence)
Ensembl Gene Model ENSMUSG00000028426 (Evidence)
Entrez Gene 19359 (Evidence)
UniGene 196846
DFCI TC1573283, TC1636654, TC1587417, TC1586160, TC1775891
DoTS DT.91396948, DT.55116683, DT.94178817, DT.99845085, DT.94383541
NIA Mouse Gene Index U004351
PDB 2F4M, 2F4O
Consensus CDS Project CCDS18194.1
International Mouse Phenotyping Consortium Status Rad23b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007227 VEGA Gene Model | MGI Sequence Detail 42195 C57BL/6J ±  kb
transcript OTTMUST00000016670 VEGA | MGI Sequence Detail 3810 Not Applicable 
polypeptide OTTMUSP00000007676 VEGA | MGI Sequence Detail 416 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(216 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006636 Heat shock chaperonin-binding
InterPro IPR009060 UBA-like
InterPro IPR000626 Ubiquitin
InterPro IPR000449 Ubiquitin-associated/translation elongation factor EF1B, N-terminal
InterPro IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
InterPro IPR004806 UV excision repair protein Rad23
InterPro IPR015360 XPC-binding domain
Protein Ontology PR:000013670 UV excision repair protein RAD23 homolog B
References
(Earliest) J:30878 van der Spek PJ, et al., Cloning, comparative mapping, and RNA expression of the mouse homologues of the Saccharomyces cerevisiae nucleotide excision repair gene RAD23. Genomics. 1996 Jan 1;31(1):20-7
(Latest) J:221330 Cattoglio C, et al., Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells. Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2317-26
All references(49)
Other
accession IDs
MGD-MRK-32169, MGI:1925602, MGI:2140506

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory