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Atf6b Gene Detail
Summary
  • Symbol
    Atf6b
  • Name
    activating transcription factor 6 beta
  • Synonyms
    ATF6beta, Crebl1, Creb-rp
  • Feature Type
    protein coding gene
  • IDs
    MGI:105121
    NCBI Gene: 12915
  • Gene Overview
    MyGene.info: ATF6B
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34647146-34655074 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105121
protein coding gene Chr17:34647146-34655074 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023586
protein coding gene Chr17:34729003-34736931 (+)
A/J MGP_AJ_G0023548
protein coding gene Chr17:33545247-33553190 (+)
AKR/J MGP_AKRJ_G0023513
protein coding gene Chr17:33964863-33972806 (+)
BALB/cJ MGP_BALBcJ_G0023552
protein coding gene Chr17:33694289-33702216 (+)
C3H/HeJ MGP_C3HHeJ_G0023312
protein coding gene Chr17:34358828-34366771 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023992
protein coding gene Chr17:36054445-36062373 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021471
protein coding gene Chr17:31434735-31442651 (+)
CAST/EiJ MGP_CASTEiJ_G0022812
protein coding gene Chr17:34430968-34438904 (+)
CBA/J MGP_CBAJ_G0023290
protein coding gene Chr17:37575431-37583372 (+)
DBA/2J MGP_DBA2J_G0023418
protein coding gene Chr17:32835415-32843342 (+)
FVB/NJ MGP_FVBNJ_G0023385
protein coding gene Chr17:32739708-32747661 (+)
LP/J MGP_LPJ_G0023496
protein coding gene Chr17:35000916-35008844 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023408
protein coding gene Chr17:36464228-36472159 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024035
protein coding gene Chr17:34272483-34280432 (+)
PWK/PhJ MGP_PWKPhJ_G0022560
protein coding gene Chr17:31764728-31772666 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022377
protein coding gene Chr17:32259837-32267804 (+)
WSB/EiJ MGP_WSBEiJ_G0022873
protein coding gene Chr17:34366941-34374867 (+)



Homology
more
  • Human Ortholog
    ATF6B, activating transcription factor 6 beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ATF6B, activating transcription factor 6 beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CREBL1, CREB-RP, G13
  • Links
    NCBI Gene ID: 1388
    neXtProt AC: NX_Q99941
    UniProt: Q99941

  • Chr Location
    6p21.32; chr6:32115268-32128240 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased cellular sensitivity to thapsigargin and tunicamycin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12915 NCBI Gene Model | MGI Sequence Detail 7929 C57BL/6J ±  kb
transcript NM_017406 RefSeq | MGI Sequence Detail 2586 C57BL/6  
polypeptide O35451 UniProt | EBI | MGI Sequence Detail 699 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR029809 cAMP-dependent transcription factor ATF-6 beta
Molecular
Reagents
less
  • All nucleic 68
    Genomic 1
    cDNA 65
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-32162, MGI:2146775
References
more
  • Summaries
    All 47
    Developmental Gene Expression 9
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:22448 Matsumoto K, et al., The distribution of tenascin-X is distinct and often reciprocal to that of tenascin-C. J Cell Biol. 1994 Apr;125(2):483-93
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory